WormBase Tree Display for Gene: WBGene00006448
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| WBGene00006448 | SMap | S_parent | Sequence | C16C10 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | glod-4 | Person_evidence | WBPerson4055 | |||||
| Sequence_name | C16C10.10 | ||||||||
| Molecular_name | C16C10.10 | ||||||||
| C16C10.10.1 | |||||||||
| CE01490 | |||||||||
| Other_name | tag-73 | Person_evidence | WBPerson201 | ||||||
| CELE_C16C10.10 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | glod-4 | ||||||||
| DB_info | Database | AceView | gene | 3F243 | |||||
| WormQTL | gene | WBGene00006448 | |||||||
| WormFlux | gene | WBGene00006448 | |||||||
| NDB | locus_tag | CELE_C16C10.10 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006448|UniProtKB=Q09253 | |||||||
| family | PTHR46466 | ||||||||
| NCBI | gene | 175530 | |||||||
| RefSeq | protein | NM_065426.5 | |||||||
| SwissProt | UniProtAcc | Q09253 | |||||||
| TREEFAM | TREEFAM_ID | TF105801 | |||||||
| UniProt_GCRP | UniProtAcc | Q09253 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 20 Jul 2007 11:50:19 | WBPerson2970 | Name_change | CGC_name | glod-1 | ||||
| Other_name | tag-73 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | glod | ||||||||
| Allele (16) | |||||||||
| Strain | WBStrain00003573 | ||||||||
| WBStrain00035694 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation | 00053090 | ||||||||
| 00053091 | |||||||||
| 00053092 | |||||||||
| 00053093 | |||||||||
| Contained_in_operon | CEOP3152 | ||||||||
| Ortholog (36) | |||||||||
| Structured_description | Concise_description | glod-4 encodes a glyoxalase required for normal lifespan, orthologous to human GLOD4; GLOD-4 is expressed in the larval and adult pharynx, pharyngeal-intestinal valve, intestine, anal sphincter, seam cells, amphids, and neurons, and in the adult reproductive system; overexpression of GLOD-4 increases glyoxalase activity 200-fold, reduces oxidative stress markers, and extends lifespan, probably by removing methylglyoxal from mitochondrial proteins, while glod-4(RNAi) animals exhibit increased methylglyoxalation of mitochondrial proteins and reduced lifespan; GLOD-4 activity normally decreases in vivo with age, despite unchanged levels of glod-4 mRNA. | Paper_evidence | WBPaper00006525 | |||||
| WBPaper00031006 | |||||||||
| WBPaper00031464 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 31 Mar 2008 00:00:00 | ||||||||
| Automated_description | Involved in determination of adult lifespan and methylglyoxal metabolic process. Expressed widely. Is an ortholog of human GLOD4 (glyoxalase domain containing 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C16C10.10 | |||||||
| Corresponding_transcript | C16C10.10.1 | ||||||||
| Other_sequence (52) | |||||||||
| Associated_feature | WBsf224687 | ||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern | Chronogram500 | ||||||||
| Chronogram1707 | |||||||||
| Expr5277 | |||||||||
| Expr8050 | |||||||||
| Expr1018742 | |||||||||
| Expr1032626 | |||||||||
| Expr1144720 | |||||||||
| Expr2012109 | |||||||||
| Expr2030345 | |||||||||
| Drives_construct | WBCnstr00000582 | ||||||||
| WBCnstr00000583 | |||||||||
| WBCnstr00004025 | |||||||||
| WBCnstr00034352 | |||||||||
| Construct_product | WBCnstr00034352 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (93) | |||||||||
| Interaction (15) | |||||||||
| Map_info | Map | III | Position | -3.77504 | Error | 0.009327 | |||
| Positive | Positive_clone | C16C10 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 4785 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00031464 | ||||||||
| WBPaper00038491 | |||||||||
| WBPaper00039011 | |||||||||
| WBPaper00050335 | |||||||||
| WBPaper00050372 | |||||||||
| WBPaper00051612 | |||||||||
| WBPaper00053669 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00055164 | |||||||||
| WBPaper00066034 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
