WormBase Tree Display for Gene: WBGene00006557

WBGene00006557 Evidence: Author_evidence: Woollard AS
  SMap: S_parent: Sequence: C24H11
  Identity: Version: 1
    Name: CGC_name: tbx-38
      Sequence_name: C24H11.3
      Molecular_name: C24H11.3
        C24H11.3.1
        CE18526
      Other_name: CELE_C24H11.3 Accession_evidence: NDB BX284603
      Public_name: tbx-38
    DB_info: Database: AceView gene 3M874
        WormQTL gene WBGene00006557
        WormFlux gene WBGene00006557
        NDB locus_tag CELE_C24H11.3
        Panther gene CAEEL|WormBase=WBGene00006557|UniProtKB=Q9XVD5
          family PTHR11267
        NCBI gene 182861
        RefSeq protein NM_067125.3
        SwissProt UniProtAcc Q9XVD5
        UniProt_GCRP UniProtAcc Q9XVD5
        OMIM gene 300307
            601719
            602427
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tbx
    Allele (51)
    Strain: WBStrain00033862
      WBStrain00050742
      WBStrain00050741
      WBStrain00050740
      WBStrain00050739
      WBStrain00051970
    RNASeq_FPKM (74)
    GO_annotation (17)
    Ortholog (79)
    Paralog (21)
    Structured_description: Concise_description: tbx-38 encodes a T box transcription factor; during embryonic development, tbx-38 functions redundantly with tbx-37 to effect Notch-mediated pharyngeal mesoderm induction in descendants of the ABa blastomere; in addition, tbx-38 and tbx-37 are required for proper cell fate specification of other ABa descendants, such as those that give rise to hypodermal tissue; TBX-38 expression appears to be limited to the 8 ABa descendents at the 24-cell stage of embryogenesis, with expression diminishing markedly during the next cell cycle; negative regulation of TBX-38 expression in ABp descendants depends upon Notch signaling, while negative regulation of expression in EMS descendents is likely controlled, in part, by ref-1 and unc-37, which encode bHLH and Groucho-like proteins, respectively. Paper_evidence: WBPaper00013403
            WBPaper00025235
          Curator_confirmed: WBPerson1843
          Date_last_updated: 01 Feb 2007 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pharynx development. Located in nucleus. Expressed in head neurons. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and bone disease (multiple). Is an ortholog of several human genes including TBX15 (T-box transcription factor 15); TBX4 (T-box transcription factor 4); and TBX6 (T-box transcription factor 6). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111382 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11603)
      DOID:381 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11603)
      DOID:0111826 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11600)
      DOID:0112363 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11605)
      DOID:674 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11600)
      DOID:0060613 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:11600)
  Molecular_info: Corresponding_CDS: C24H11.3
    Corresponding_transcript: C24H11.3.1
    Other_sequence: CRC02805_1
    Associated_feature: WBsf651516
      WBsf978917
      WBsf227599
    Transcription_factor: WBTranscriptionFactor000214
  Experimental_info: RNAi_result: WBRNAi00041118 Inferred_automatically: RNAi_primary
      WBRNAi00029162 Inferred_automatically: RNAi_primary
      WBRNAi00011127 Inferred_automatically: RNAi_primary
      WBRNAi00006121 Inferred_automatically: RNAi_primary
    Expr_pattern (11)
    Drives_construct: WBCnstr00001749
      WBCnstr00001750
      WBCnstr00012588
      WBCnstr00015339
      WBCnstr00015340
      WBCnstr00016159
    Construct_product: WBCnstr00001750
      WBCnstr00016170
    Antibody: WBAntibody00000888
    Microarray_results (19)
    Expression_cluster (117)
    Interaction (44)
  Map_info: Map: III Position: 13.2331 Error: 0.067301
    Positive: Positive_clone: C24H11 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 5445
    Pseudo_map_position
  Reference (23)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene