WormBase Tree Display for Gene: WBGene00006604
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| WBGene00006604 | SMap | S_parent | Sequence | Y47D3A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tra-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y47D3A.6 | ||||||||
| Molecular_name | Y47D3A.6a | ||||||||
| Y47D3A.6a.1 | |||||||||
| CE52672 | |||||||||
| Y47D3A.6b | |||||||||
| CE52664 | |||||||||
| Y47D3A.6b.1 | |||||||||
| Other_name | her-2 | ||||||||
| CELE_Y47D3A.6 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | tra-1 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tra | ||||||||
| Reference_allele | WBVar00143741 | ||||||||
| WBVar00144118 | |||||||||
| Allele (603) | |||||||||
| Legacy_information | e1099 : XX animals transformed into low fertility males; gonad morphology variable testes reduced in size few sperm made; XO phenotype male. ES3 ME1 (XX). NA (recessive) > 15 (e1781amber (soma male gonad contains apparent oocytes) e1488 (gonad and intestine hermaphrodite (self- fertile) rest of body male) e1732 (gonad more masculinized than body) etc.). Also Class 2 (gain-of-function) alleles e1575sd (pka her-2) : both XX and XO animals transformed into fertile females by e1575 or e1575/+. ES3 ME0. NA (dominant) > 15 (some weaker than e1575 cause incomplete feminization). Also intragenic revertants of dominants resemble Class 1 alleles. NA > 30. | ||||||||
| See tra-1. | |||||||||
| See also e1488, e1575, e1816, e1819, e1822, e1825, e1828, e1829, e1830, e1831, e1832, e1833, e1834, e1835, e1836, e1837, e1838, e1840, e1843, e1844, e1845, e1846, e1847, e1849, e1850, e1853, e1855, e1856, e1857, e1858, e1859, e1860, e1951, e1953, e1961, e1962, e1993, e1997, e1998, e2009, e2013, e2014, e2065, e2067, e2069, e2071, e2097, e2098, e2099, e2109, e2198, e2200, e2201, e2270, e2271, e2272, e2276, e2277, e2278, e2326, e2332, e2334, e2351, e2352, e2363, e2368, e2389, e2424, e2427, n1105, oz6, q312, rh132, y7 | |||||||||
| [C.elegansII] e1099 : XX animals transformed into low fertility males; gonad morphology variable, testes reduced in size, few sperm made; XO phenotype male, similar gonad defects. ES3 ME1 (XX, XO). OA>20 (recessive): e1834ird (deletion, probable null, resembles e1099), e1781amb (soma male, gonad contains apparent oocytes), e1488 (gonad and intestine hermaphrodite (self-fertile), rest of body male), e1732 (gonad more masculinized than body), rh132(gonad male, tail hermaphrodite) etc. Also gain-of-function alleles: e1575sd (pka her-2, both XX and XO animals transformed into fertile females by e1575 or e1575/+. ES3 ME0. OA>20 (dominant): many weaker than e1575, causing incomplete or slight feminization. Also intragenic revertants of dominants, XX masculinizing. OA>30. Also additional phenotypic classes, complex properties. Cloned: 1.5 and 5 kb transcripts, encoding 288 aa and 1110 aa proteins with 2 and 5 zinc finger motifs, similarity to GLI family. [Hodgkin 1987; Zarkower and Hodgkin 1992; CB; DZ; JK] | |||||||||
| Strain (29) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (49) | |||||||||
| Contained_in_operon | CEOP3827 | ||||||||
| Ortholog (47) | |||||||||
| Paralog | WBGene00004335 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00012975 | Caenorhabditis elegans | From_analysis | modENCODE_Pseudogenes | ||||||
| WBGene00010936 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | tra-1 encodes Zn2+-finger-containing proteins that are the sole C. elegans members of the GLI transcription factor family; during development, tra-1 functions cell autonomously as the terminal regulator of the sex determination pathway and positively regulates all aspects of hermaphrodite somatic sexual differentiation; in addition, tra-1 activity is required for proper development of the male somatic gonad and for sustained spermatogenesis in both sexes; in regulating sex-specific development, TRA-1 functions, in part, by repressing transcription of mab-3 and egl-1 in the intestine and HSN neurons, respectively; TRA-1 is expressed in hermaphrodites and males and localizes to both the nucleus and cytoplasm of many different cell types; expression of C-terminally truncated TRA-1 isoforms is much higher in hermaphrodites than males, due to sex-specific proteolysis that results in the presence of feminizing TRA-1 isoforms in hermaphrodites. | Paper_evidence (12) | ||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 12 Dec 2006 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in developmental process involved in reproduction; negative regulation of transcription by RNA polymerase II; and positive regulation of neuron apoptotic process. Located in cytoplasm and nucleus. Expressed in several structures, including AWA; germ line; gonad; intestine; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including Culler-Jones syndrome; gastrointestinal system cancer (multiple); and synostosis (multiple). Is an ortholog of human GLI1 (GLI family zinc finger 1); GLI2 (GLI family zinc finger 2); and GLI3 (GLI family zinc finger 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (18) | ||||||||
| Molecular_info | Corresponding_CDS | Y47D3A.6a | |||||||
| Y47D3A.6b | |||||||||
| Corresponding_CDS_history | Y47D3A.6:wp52 | ||||||||
| Y47D3A.6a:wp265 | |||||||||
| Y47D3A.6b:wp265 | |||||||||
| Corresponding_transcript | Y47D3A.6a.1 | ||||||||
| Y47D3A.6b.1 | |||||||||
| Other_sequence (14) | |||||||||
| Associated_feature (32) | |||||||||
| Gene_product_binds | WBsf019099 | ||||||||
| WBsf034321 | |||||||||
| WBsf034334 | |||||||||
| WBsf047586 | |||||||||
| WBsf919544 | |||||||||
| Transcription_factor | WBTranscriptionFactor000029 | ||||||||
| Experimental_info | RNAi_result (22) | ||||||||
| Expr_pattern (22) | |||||||||
| Drives_construct | WBCnstr00000512 | ||||||||
| WBCnstr00000515 | |||||||||
| WBCnstr00001898 | |||||||||
| WBCnstr00002724 | |||||||||
| WBCnstr00002787 | |||||||||
| WBCnstr00011056 | |||||||||
| WBCnstr00011123 | |||||||||
| Construct_product | WBCnstr00010051 | ||||||||
| WBCnstr00010427 | |||||||||
| WBCnstr00011123 | |||||||||
| WBCnstr00021700 | |||||||||
| Antibody | WBAntibody00000775 | ||||||||
| WBAntibody00000776 | |||||||||
| WBAntibody00000948 | |||||||||
| WBAntibody00001181 | |||||||||
| WBAntibody00001275 | |||||||||
| WBAntibody00002025 | |||||||||
| WBAntibody00002228 | |||||||||
| WBAntibody00002808 | |||||||||
| Microarray_results (38) | |||||||||
| Expression_cluster (131) | |||||||||
| Interaction (240) | |||||||||
| WBProcess | WBbiopr:00000123 | ||||||||
| Map_info | Map | III | Position | 6.88967 | Error | 0.104832 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | eDf20 | |||||||
| tDf1 | |||||||||
| tDp1 | |||||||||
| tDp2 | |||||||||
| Positive_clone | F56C2 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Y47D3A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 87 | |||||||
| 4229 | |||||||||
| Multi_point (11) | |||||||||
| Pos_neg_data | 5730 | ||||||||
| 5739 | |||||||||
| 5946 | |||||||||
| 351 | |||||||||
| 1599 | |||||||||
| 8372 | |||||||||
| Landmark_gene | |||||||||
| Reference (412) | |||||||||
| Picture | WBPicture0000013095 | ||||||||
| Method | Gene |
