WormBase Tree Display for Gene: WBGene00006742
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| WBGene00006742 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-2 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T02C5.5 | ||||||||
| Molecular_name (45) | |||||||||
| Other_name | CELE_T02C5.5 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | unc-2 | ||||||||
| DB_info | Database | AceView | gene | XD330 | |||||
| WormQTL | gene | WBGene00006742 | |||||||
| WormFlux | gene | WBGene00006742 | |||||||
| OMIM | disease | 141500 | |||||||
| gene | 601011 | ||||||||
| 601013 | |||||||||
| NDB | locus_tag | CELE_T02C5.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006742|UniProtKB=A0A3B1E663 | |||||||
| family | PTHR45628 | ||||||||
| NCBI | gene | 180570 | |||||||
| RefSeq | protein (15) | ||||||||
| TrEMBL | UniProtAcc | A0A1N7SYV7 | |||||||
| A0A1N7SYU0 | |||||||||
| A0A1N7SYV5 | |||||||||
| A0A3B1E663 | |||||||||
| A0A1N7SYT1 | |||||||||
| G5EFB0 | |||||||||
| A0A3B1E695 | |||||||||
| A0A1N7SYT0 | |||||||||
| A0A1N7SYU6 | |||||||||
| A0A1N7SYU4 | |||||||||
| Q86G45 | |||||||||
| A0A1N7SYT8 | |||||||||
| A0A3B1DR32 | |||||||||
| A0A3B1E4Z9 | |||||||||
| Q8MPY5 | |||||||||
| UniProt_GCRP | UniProtAcc | A0A3B1E663 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00142938 | ||||||||
| Allele (946) | |||||||||
| Legacy_information | e55 : weak kinker sluggish thin. ES3 ME2. NA3 (e97 e129). | ||||||||
| See also e2342, e2379 | |||||||||
| [C.elegansII] e55 : weak kinker; sluggish; thin; hypersensitive to serotonin, fails to desensitize to dopamine. ES3 ME2. OA>10: e97, e129, e2379 (Unc, only subtle defect in adaptation), mu74 (resembles e55, deletion,probable null), pk95tci, etc. Cloned: 7.5 kb transcript, present throughout development, encodes protein homologous (41-65%)to alpha1 subunit of mammalian neuronal voltage-sensitive calcium channel. [Schafer and Kenyon 1995; DM] | |||||||||
| Strain (23) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (33) | |||||||||
| Ortholog (39) | |||||||||
| Paralog | WBGene00001187 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00000367 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00003558 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006809 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00008911 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-2 encodes a calcium channel alpha subunit similar to the human P/Q-type calcium channel, CACNA1A; unc-2 is required for desensitization to dopamine, normal movement, normally low sensitivity of whole animals to serotonin, and neuronal migrations; unc-2 interacts with the TGF beta pathway to regulate movement, and maintain normal serotonin levels; unc-2/TGF beta pathway is also required for the stress-induced modulation of tryptophan hydroxylase/tph-1 expression in the serotonergic chemosensory ADF neurons (but not the NSM neurons); UNC-2 is expressed primarily in motor neurons, several sensory neurons, and the HSN and VC neurons controlling egg-laying. | Paper_evidence | WBPaper00002168 | |||||
| WBPaper00003955 | |||||||||
| WBPaper00004637 | |||||||||
| WBPaper00005551 | |||||||||
| WBPaper00006005 | |||||||||
| WBPaper00006272 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 15 May 2012 00:00:00 | ||||||||
| Automated_description | Predicted to enable high voltage-gated calcium channel activity. Involved in several processes, including determination of left/right asymmetry in nervous system; negative regulation of transforming growth factor beta receptor signaling pathway; and response to heat. Located in presynaptic active zone membrane. Expressed in several structures, including body wall musculature; excretory canal; nerve ring; neurons; and pharyngeal muscle cell. Used to study migraine. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system (multiple); brain disease (multiple); and episodic ataxia type 2. Is an ortholog of human CACNA1B (calcium voltage-gated channel subunit alpha1 B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:6364 | Homo sapiens | Paper_evidence | WBPaper00006272 | ||||
| Accession_evidence | OMIM | 141500 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 14 Apr 2014 00:00:00 | ||||||||
| Potential_model | DOID:10024 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | |||||
| DOID:0080454 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | ||||||
| DOID:0050956 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | ||||||
| DOID:0112205 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1392) | ||||||
| DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1389) | ||||||
| DOID:0111181 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | ||||||
| DOID:0050214 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1389) | ||||||
| DOID:0050990 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | ||||||
| DOID:4724 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1389) | ||||||
| DOID:6364 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1388) | ||||||
| Disease_relevance | Mutations in the human calcium channel CACNA1A (Calcium channel, voltage-dependent, P/Q type, alpha-1A subunit) are associated with Episodic ataxia (type 2), which affects the nervous system, resulting in migraines, vision and speech defects, and muscle weakness; mutations in CACNA1A also cause Spinocerebellar ataxia (type 6), a progressive movement disorder; voltage dependent calcium channels mediate calcium entry into cells and are involved in several calcium dependent processes; genetic studies in elegans show that unc-2, the ortholog of CACNA1A, negatively modulates a transforming growth factor (TGF)-beta pathway to affect certain phenotypes like movement, and for the normal accumulation of serotonin levels; further, unc-2 dependent inhibition of the TGF-beta pathway regulates the transcriptional expression of trytophan hydroxylase (tph-1) in serotonergic neurons under stress conditions like starvation and raised temperature; a construct expressing human CACNA1A can substitute for unc-2 function in elegans. | Homo sapiens | Paper_evidence | WBPaper00006272 | |||||
| Accession_evidence | OMIM | 601011 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 14 Apr 2014 00:00:00 | ||||||||
| Models_disease_in_annotation | WBDOannot00000025 | ||||||||
| Molecular_info | Corresponding_CDS (15) | ||||||||
| Corresponding_CDS_history | T02C5.5b:wp102 | ||||||||
| T02C5.5d:wp271 | |||||||||
| T02C5.5e:wp272 | |||||||||
| Corresponding_transcript (15) | |||||||||
| Other_sequence (50) | |||||||||
| Associated_feature (42) | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00003100 | ||||||||
| WBCnstr00003101 | |||||||||
| WBCnstr00004845 | |||||||||
| WBCnstr00004847 | |||||||||
| WBCnstr00038221 | |||||||||
| Construct_product | WBCnstr00005852 | ||||||||
| WBCnstr00005853 | |||||||||
| WBCnstr00005854 | |||||||||
| WBCnstr00020432 | |||||||||
| WBCnstr00022471 | |||||||||
| WBCnstr00023025 | |||||||||
| WBCnstr00023027 | |||||||||
| Microarray_results (47) | |||||||||
| Expression_cluster (201) | |||||||||
| Interaction (139) | |||||||||
| Anatomy_function | WBbtf0544 | ||||||||
| WBbtf0547 | |||||||||
| WBbtf0550 | |||||||||
| Map_info | Map | X | Position | -13.7946 | Error | 0.063386 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | T02C5 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 145 | |||||||
| 153 | |||||||||
| 154 | |||||||||
| 155 | |||||||||
| 156 | |||||||||
| 157 | |||||||||
| 3151 | |||||||||
| 4456 | |||||||||
| 4457 | |||||||||
| 7099 | |||||||||
| Multi_point (28) | |||||||||
| Pos_neg_data (23) | |||||||||
| Landmark_gene | |||||||||
| Reference (201) | |||||||||
| Method | Gene |
