WormBase Tree Display for Gene: WBGene00006742

WBGene00006742 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: unc-2 Person_evidence: WBPerson261
      Sequence_name: T02C5.5
      Molecular_name (45)
      Other_name: CELE_T02C5.5 Accession_evidence: NDB BX284606
      Public_name: unc-2
    DB_info: Database: AceView gene XD330
        WormQTL gene WBGene00006742
        WormFlux gene WBGene00006742
        OMIM disease 141500
          gene 601011
            601013
        NDB locus_tag CELE_T02C5.5
        Panther gene CAEEL|WormBase=WBGene00006742|UniProtKB=A0A3B1E663
          family PTHR45628
        NCBI gene 180570
        RefSeq protein NM_001348590.4
            NM_001348592.5
            NM_001348589.4
            NM_001348588.4
            NM_001368494.4
            NM_001348593.4
            NM_001348594.5
            NM_001348597.2
            NM_001348591.4
            NM_001368497.5
            NM_001348595.4
            NM_001368495.4
            NM_001348596.5
            NM_171638.3
            NM_001368496.4
        TrEMBL UniProtAcc (15)
        UniProt_GCRP UniProtAcc A0A3B1E663
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (11)
  Disease_info: Experimental_model: DOID:6364 Homo sapiens Paper_evidence: WBPaper00006272
          Accession_evidence: OMIM 141500
          Curator_confirmed: WBPerson324
          Date_last_updated: 14 Apr 2014 00:00:00
    Potential_model: DOID:10024 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
      DOID:0080454 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
      DOID:0050956 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
      DOID:0112205 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1392)
      DOID:2377 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1389)
      DOID:0111181 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
      DOID:0050214 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1389)
      DOID:0050990 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
      DOID:4724 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1389)
      DOID:6364 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1388)
    Disease_relevance: Mutations in the human calcium channel CACNA1A (Calcium channel, voltage-dependent, P/Q type, alpha-1A subunit) are associated with Episodic ataxia (type 2), which affects the nervous system, resulting in migraines, vision and speech defects, and muscle weakness; mutations in CACNA1A also cause Spinocerebellar ataxia (type 6), a progressive movement disorder; voltage dependent calcium channels mediate calcium entry into cells and are involved in several calcium dependent processes; genetic studies in elegans show that unc-2, the ortholog of CACNA1A, negatively modulates a transforming growth factor (TGF)-beta pathway to affect certain phenotypes like movement, and for the normal accumulation of serotonin levels; further, unc-2 dependent inhibition of the TGF-beta pathway regulates the transcriptional expression of trytophan hydroxylase (tph-1) in serotonergic neurons under stress conditions like starvation and raised temperature; a construct expressing human CACNA1A can substitute for unc-2 function in elegans. Homo sapiens Paper_evidence: WBPaper00006272
          Accession_evidence: OMIM 601011
          Curator_confirmed: WBPerson324
          Date_last_updated: 14 Apr 2014 00:00:00
  Models_disease_in_annotation: WBDOannot00000025
  Molecular_info: Corresponding_CDS (15)
    Corresponding_CDS_history: T02C5.5b:wp102
      T02C5.5d:wp271
      T02C5.5e:wp272
    Corresponding_transcript (15)
    Other_sequence (50)
    Associated_feature (42)
  Experimental_info: RNAi_result (18)
    Expr_pattern (13)
    Drives_construct: WBCnstr00003100
      WBCnstr00003101
      WBCnstr00004845
      WBCnstr00004847
      WBCnstr00038221
    Construct_product: WBCnstr00005852
      WBCnstr00005853
      WBCnstr00005854
      WBCnstr00020432
      WBCnstr00022471
      WBCnstr00023025
      WBCnstr00023027
    Microarray_results (47)
    Expression_cluster (201)
    Interaction: WBInteraction000000410
      WBInteraction000002254
      WBInteraction000002255
      WBInteraction000002258
      WBInteraction000002260
      WBInteraction000002261
      WBInteraction000002262
      WBInteraction000002263
      WBInteraction000008869
      WBInteraction000008870
      WBInteraction000008871
      WBInteraction000008872
      WBInteraction000008904
      WBInteraction000009060
      WBInteraction000009061
      WBInteraction000009494
      WBInteraction000009928
      WBInteraction000028632
      WBInteraction000028727
      WBInteraction000029224
      WBInteraction000029330
      WBInteraction000029651
      WBInteraction000030267
      WBInteraction000033455
      WBInteraction000034453
      WBInteraction000035594
      WBInteraction000036200
      WBInteraction000038740
      WBInteraction000038741
      WBInteraction000039739
      WBInteraction000040058
      WBInteraction000040156
      WBInteraction000041919
      WBInteraction000042508
      WBInteraction000043987
      WBInteraction000044198
      WBInteraction000045155
      WBInteraction000045217
      WBInteraction000045899
      WBInteraction000045936
      WBInteraction000046901
      WBInteraction000047252
      WBInteraction000047883
      WBInteraction000048022
      WBInteraction000049336
      WBInteraction000050013
      WBInteraction000050014
      WBInteraction000052099
      WBInteraction000052101
      WBInteraction000052793
      WBInteraction000115442
      WBInteraction000124620
      WBInteraction000124967
      WBInteraction000125937
      WBInteraction000125938
      WBInteraction000126011
      WBInteraction000126296
      WBInteraction000126297
      WBInteraction000126298
      WBInteraction000126330
      WBInteraction000126463
      WBInteraction000126596
      WBInteraction000126802
      WBInteraction000127094
      WBInteraction000127126
      WBInteraction000127275
      WBInteraction000127276
      WBInteraction000127411
      WBInteraction000127521
      WBInteraction000132991
      WBInteraction000133350
      WBInteraction000133351
      WBInteraction000133364
      WBInteraction000133690
      WBInteraction000133844
      WBInteraction000133845
      WBInteraction000134943
      WBInteraction000134944
      WBInteraction000135319
      WBInteraction000139427
      WBInteraction000157026
      WBInteraction000158621
      WBInteraction000160349
      WBInteraction000163174
      WBInteraction000165606
      WBInteraction000165626
      WBInteraction000165633
      WBInteraction000165653
      WBInteraction000165660
      WBInteraction000166372
      WBInteraction000166396
      WBInteraction000166940
      WBInteraction000167157
      WBInteraction000173896
      WBInteraction000173991
      WBInteraction000204106
      WBInteraction000204107
      WBInteraction000209621
      WBInteraction000212022
      WBInteraction000237300
      WBInteraction000240467
      WBInteraction000251953
      WBInteraction000252758
      WBInteraction000252759
      WBInteraction000252760
      WBInteraction000252761
      WBInteraction000252762
      WBInteraction000297575
      WBInteraction000306605
      WBInteraction000338456
      WBInteraction000338457
      WBInteraction000338458
      WBInteraction000338459
      WBInteraction000339724
      WBInteraction000362003
      WBInteraction000375769
      WBInteraction000377216
      WBInteraction000377726
      WBInteraction000380286
      WBInteraction000381013
      WBInteraction000392443
      WBInteraction000393515
      WBInteraction000398581
      WBInteraction000414111
      WBInteraction000414112
      WBInteraction000415230
      WBInteraction000423514
      WBInteraction000439794
      WBInteraction000447618
      WBInteraction000447619
      WBInteraction000464729
      WBInteraction000468635
      WBInteraction000472748
      WBInteraction000472749
      WBInteraction000472750
      WBInteraction000501477
      WBInteraction000501479
      WBInteraction000502185
      WBInteraction000519343
    Anatomy_function: WBbtf0544
      WBbtf0547
      WBbtf0550
  Map_info: Map: X Position: -13.7946 Error: 0.063386
    Well_ordered
    Positive: Positive_clone: T02C5 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 145
        153
        154
        155
        156
        157
        3151
        4456
        4457
        7099
      Multi_point (28)
      Pos_neg_data (23)
    Landmark_gene
  Reference (201)
  Method: Gene