WormBase Tree Display for Gene: WBGene00006743

WBGene00006743 SMap: S_parent: Sequence: CHROMOSOME_X
  Identity: Version: 1
    Name: CGC_name: unc-3 Person_evidence: WBPerson261
      Sequence_name: Y16B4A.1
      Molecular_name: Y16B4A.1
        Y16B4A.1.1
        CE29366
      Other_name: CELE_Y16B4A.1 Accession_evidence: NDB BX284606
      Public_name: unc-3
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142996
    Allele (232)
    Legacy_information: e151 : weak coiler tends to coil tail active; very disorganized ventral nerve cord; mutant focus in ABp descendants; ES3 ME1. Similar phenotype in e151/Df. NA4 (e54 (weaker allele) e95 etc.).
      [C.elegansII] e151 : weak coiler tends to coil, tail active, good head movement; very disorganized ventral nerve cord; mosaic analysis indicates mutant focus in ventral cord motor neurons. Similar phenotype ine151/Df. ES3 ME1.OA>5: e54 (weaker allele), e95, mn419, p1001 etc. Cloned: polymorphisms identified in mn419 and derivatives (cosmid F42D1). [Brenner 1974; Herman and Kari 1987; NG; SP]
    Strain (93)
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (46)
    Structured_description: Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and identical protein binding activity. Involved in several processes, including dauer larval development; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ABalappaap; ABalappaapp; and neurons. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Is an ortholog of several human genes including EBF1 (EBF transcription factor 1); EBF2 (EBF transcription factor 2); and EBF4 (EBF family member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0081176 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:19087)
  Molecular_info: Corresponding_CDS: Y16B4A.1
    Corresponding_CDS_history: Y16B4A.1:wp62
    Corresponding_transcript: Y16B4A.1.1
    Other_sequence (23)
    Associated_feature: WBsf648757
      WBsf648758
      WBsf663592
      WBsf663593
      WBsf663594
      WBsf663595
      WBsf663596
      WBsf978939
      WBsf1008002
      WBsf1008003
      WBsf1008004
      WBsf1008005
      WBsf1008006
      WBsf1008007
      WBsf1024459
      WBsf1024460
      WBsf1024461
      WBsf1024462
      WBsf236718
    Transcription_factor: WBTranscriptionFactor000217
  Experimental_info: RNAi_result: WBRNAi00115872 Inferred_automatically: RNAi_primary
      WBRNAi00090173 Inferred_automatically: RNAi_primary
      WBRNAi00090014 Inferred_automatically: RNAi_primary
      WBRNAi00027739 Inferred_automatically: RNAi_primary
      WBRNAi00020068 Inferred_automatically: RNAi_primary
      WBRNAi00055554 Inferred_automatically: RNAi_primary
      WBRNAi00062789 Inferred_automatically: RNAi_primary
      WBRNAi00008787 Inferred_automatically: RNAi_primary
      WBRNAi00090332 Inferred_automatically: RNAi_primary
      WBRNAi00089778 Inferred_automatically: RNAi_primary
    Expr_pattern (13)
    Drives_construct (11)
    Construct_product (14)
    Antibody: WBAntibody00000177
    Microarray_results (21)
    Expression_cluster (188)
    Interaction: WBInteraction000000034
      WBInteraction000000133
      WBInteraction000001147
      WBInteraction000001150
      WBInteraction000001152
      WBInteraction000001154
      WBInteraction000001157
      WBInteraction000001210
      WBInteraction000001215
      WBInteraction000001220
      WBInteraction000001225
      WBInteraction000001226
      WBInteraction000001227
      WBInteraction000002363
      WBInteraction000003343
      WBInteraction000003365
      WBInteraction000003367
      WBInteraction000003522
      WBInteraction000004696
      WBInteraction000005398
      WBInteraction000005833
      WBInteraction000005834
      WBInteraction000005835
      WBInteraction000005836
      WBInteraction000005837
      WBInteraction000005838
      WBInteraction000009581
      WBInteraction000009601
      WBInteraction000028343
      WBInteraction000028372
      WBInteraction000028652
      WBInteraction000028968
      WBInteraction000029206
      WBInteraction000029406
      WBInteraction000029652
      WBInteraction000029653
      WBInteraction000029831
      WBInteraction000029882
      WBInteraction000030242
      WBInteraction000031696
      WBInteraction000032585
      WBInteraction000032856
      WBInteraction000032857
      WBInteraction000032859
      WBInteraction000033293
      WBInteraction000033294
      WBInteraction000034676
      WBInteraction000037624
      WBInteraction000037625
      WBInteraction000039173
      WBInteraction000039213
      WBInteraction000039993
      WBInteraction000040277
      WBInteraction000043179
      WBInteraction000043186
      WBInteraction000043916
      WBInteraction000046364
      WBInteraction000047209
      WBInteraction000047281
      WBInteraction000047476
      WBInteraction000048414
      WBInteraction000048416
      WBInteraction000052052
      WBInteraction000052053
      WBInteraction000052088
      WBInteraction000052290
      WBInteraction000126299
      WBInteraction000126300
      WBInteraction000126301
      WBInteraction000126303
      WBInteraction000126322
      WBInteraction000126331
      WBInteraction000126332
      WBInteraction000126333
      WBInteraction000126334
      WBInteraction000126463
      WBInteraction000126588
      WBInteraction000126708
      WBInteraction000126716
      WBInteraction000126792
      WBInteraction000126992
      WBInteraction000127178
      WBInteraction000133250
      WBInteraction000133259
      WBInteraction000133283
      WBInteraction000133583
      WBInteraction000135450
      WBInteraction000136233
      WBInteraction000137883
      WBInteraction000138474
      WBInteraction000141496
      WBInteraction000144965
      WBInteraction000148647
      WBInteraction000153058
      WBInteraction000165568
      WBInteraction000165596
      WBInteraction000165609
      WBInteraction000165627
      WBInteraction000165720
      WBInteraction000166223
      WBInteraction000166373
      WBInteraction000166391
      WBInteraction000166409
      WBInteraction000166518
      WBInteraction000167023
      WBInteraction000209419
      WBInteraction000209420
      WBInteraction000209421
      WBInteraction000209422
      WBInteraction000209423
      WBInteraction000209424
      WBInteraction000209430
      WBInteraction000209431
      WBInteraction000209432
      WBInteraction000209433
      WBInteraction000209434
      WBInteraction000209435
      WBInteraction000262783
      WBInteraction000262784
      WBInteraction000262785
      WBInteraction000262786
      WBInteraction000262791
      WBInteraction000262792
      WBInteraction000262793
      WBInteraction000262794
      WBInteraction000262795
      WBInteraction000262796
      WBInteraction000292609
      WBInteraction000311016
      WBInteraction000311017
      WBInteraction000311019
      WBInteraction000311020
      WBInteraction000311021
      WBInteraction000311022
      WBInteraction000311023
      WBInteraction000311024
      WBInteraction000311025
      WBInteraction000311026
      WBInteraction000311027
      WBInteraction000311028
      WBInteraction000311029
      WBInteraction000311030
      WBInteraction000356394
      WBInteraction000356395
      WBInteraction000356396
      WBInteraction000359944
      WBInteraction000379485
      WBInteraction000398282
      WBInteraction000398285
      WBInteraction000398286
      WBInteraction000436071
      WBInteraction000463814
      WBInteraction000463815
      WBInteraction000468039
      WBInteraction000472639
      WBInteraction000472640
      WBInteraction000472641
      WBInteraction000472642
      WBInteraction000500705
      WBInteraction000500706
      WBInteraction000500707
      WBInteraction000501941
      WBInteraction000502074
      WBInteraction000503797
      WBInteraction000503798
      WBInteraction000503799
      WBInteraction000504391
      WBInteraction000525184
      WBInteraction000525185
      WBInteraction000525267
      WBInteraction000525268
      WBInteraction000525271
      WBInteraction000525272
      WBInteraction000525273
      WBInteraction000525274
      WBInteraction000525275
      WBInteraction000525276
      WBInteraction000528129
      WBInteraction000528130
      WBInteraction000528131
      WBInteraction000528180
      WBInteraction000528628
      WBInteraction000528849
      WBInteraction000530317
      WBInteraction000531578
      WBInteraction000534046
      WBInteraction000540851
      WBInteraction000540856
      WBInteraction000542030
      WBInteraction000542031
      WBInteraction000542032
      WBInteraction000542993
      WBInteraction000554878
      WBInteraction000554879
      WBInteraction000502073
  Map_info: Map: X Position: 21.3208 Error: 0.014822
    Well_ordered
    Positive: Positive_clone: F42D1
        Y16B4A Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Negative_clone: K01B4
    Mapping_data: 2_point (52)
      Multi_point (53)
      Pos_neg_data (39)
    Landmark_gene
  Reference (217)
  Remark: [Eddy SR] EcoRV RFLP correlated with unc-3. 3.8 kb EcoRV band in N2, 2.3 kb in unc-3 (mn419), 3.8 kb again in revertants unc-3 (mn419 mn422) and unc-3 (mn419 mn426), 3.7 kb in revertant unc-3 (mn419 mn431).
    Polymorphism detection method = Southern hybridisation krb 04/03/02
  Method: Gene