WormBase Tree Display for Gene: WBGene00006743
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WBGene00006743 | SMap | S_parent | Sequence | CHROMOSOME_X | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00142996 | ||||||
Allele (232) | |||||||
Legacy_information | e151 : weak coiler tends to coil tail active; very disorganized ventral nerve cord; mutant focus in ABp descendants; ES3 ME1. Similar phenotype in e151/Df. NA4 (e54 (weaker allele) e95 etc.). | ||||||
[C.elegansII] e151 : weak coiler tends to coil, tail active, good head movement; very disorganized ventral nerve cord; mosaic analysis indicates mutant focus in ventral cord motor neurons. Similar phenotype ine151/Df. ES3 ME1.OA>5: e54 (weaker allele), e95, mn419, p1001 etc. Cloned: polymorphisms identified in mn419 and derivatives (cosmid F42D1). [Brenner 1974; Herman and Kari 1987; NG; SP] | |||||||
Strain (93) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (27) | |||||||
Ortholog (46) | |||||||
Structured_description | Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone acetyltransferase binding activity; and identical protein binding activity. Involved in several processes, including dauer larval development; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in ABalappaap; ABalappaapp; and neurons. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Is an ortholog of several human genes including EBF1 (EBF transcription factor 1); EBF2 (EBF transcription factor 2); and EBF4 (EBF family member 4). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0081176 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:19087) | ||
Molecular_info | Corresponding_CDS | Y16B4A.1 | |||||
Corresponding_CDS_history | Y16B4A.1:wp62 | ||||||
Corresponding_transcript | Y16B4A.1.1 | ||||||
Other_sequence (23) | |||||||
Associated_feature (19) | |||||||
Transcription_factor | WBTranscriptionFactor000217 | ||||||
Experimental_info | RNAi_result | WBRNAi00115872 | Inferred_automatically | RNAi_primary | |||
WBRNAi00090173 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090014 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00027739 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00020068 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00055554 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062789 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00008787 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090332 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089778 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (13) | |||||||
Drives_construct (11) | |||||||
Construct_product (14) | |||||||
Antibody | WBAntibody00000177 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (188) | |||||||
Interaction (195) | |||||||
Map_info | Map | X | Position | 21.3208 | Error | 0.014822 | |
Well_ordered | |||||||
Positive | Positive_clone | F42D1 | |||||
Y16B4A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Negative | Negative_clone | K01B4 | |||||
Mapping_data (3) | |||||||
Landmark_gene | |||||||
Reference (217) | |||||||
Remark | [Eddy SR] EcoRV RFLP correlated with unc-3. 3.8 kb EcoRV band in N2, 2.3 kb in unc-3 (mn419), 3.8 kb again in revertants unc-3 (mn419 mn422) and unc-3 (mn419 mn426), 3.7 kb in revertant unc-3 (mn419 mn431). | ||||||
Polymorphism detection method = Southern hybridisation krb 04/03/02 | |||||||
Method | Gene |