WormBase Tree Display for Gene: WBGene00006745

WBGene00006745 SMap: S_parent: Sequence: B0273
  Identity: Version: 1
    Name: CGC_name: unc-5 Person_evidence: WBPerson261
      Sequence_name: B0273.4
      Molecular_name (19)
      Other_name: CELE_B0273.4 Accession_evidence: NDB BX284604
      Public_name: unc-5
    DB_info: Database: AceView gene 4G260
        WormQTL gene WBGene00006745
        WormFlux gene WBGene00006745
        NDB locus_tag CELE_B0273.4
        Panther gene CAEEL|WormBase=WBGene00006745|UniProtKB=Q26261
          family PTHR12582
        NCBI gene 177334
        RefSeq protein NM_001392311.1
            NM_068422.6
            NM_001306822.3
            NM_068421.6
            NM_001306820.3
            NM_001380233.1
        SwissProt UniProtAcc Q26261
        TREEFAM TREEFAM_ID TF316767
        UniProt_GCRP UniProtAcc Q26261
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142936
    Allele: WBVar02148984 Inferred_automatically: From strain object: FX30257
          From strain object: RG3115
          From strain object: RG3193
          From strain object: RG3197
          From strain object: RG3262
      WBVar00145484 Inferred_automatically: From strain object: VC36
      WBVar00145231
      WBVar00144797
      WBVar00143322
      WBVar00145236
      WBVar00088169
      WBVar00145229
      WBVar00095009
      WBVar00241617
      WBVar00248799
      WBVar00143158
      WBVar00145268
      WBVar00000564
      WBVar00143605
      WBVar00144772
      WBVar00144766
      WBVar00145266
      WBVar00143376
      WBVar00248800
      WBVar00248801
      WBVar00145264
      WBVar00248798
      WBVar00145239
      WBVar00143700
      WBVar00910878
      WBVar00910879
      WBVar00910880
      WBVar00297432
      WBVar00910881
      WBVar01474093
      WBVar00910882
      WBVar00910883
      WBVar00910884
      WBVar00910885
      WBVar01491059
      WBVar00910886
      WBVar00143487
      WBVar00910887
      WBVar00910888
      WBVar02125072
      WBVar00910889
      WBVar01481863
      WBVar00910890
      WBVar01630863
      WBVar01481864
      WBVar00910891
      WBVar01481865
      WBVar02125075
      WBVar00910892
      WBVar00910893
      WBVar02125076
      WBVar01481866
      WBVar00910894
      WBVar01481867
      WBVar00910895
      WBVar00259482
      WBVar00910896
      WBVar02125084
      WBVar00910897
      WBVar00910898
      WBVar02036881
      WBVar00910899
      WBVar02049866
      WBVar02036882
      WBVar00910900
      WBVar00910901
      WBVar00910902
      WBVar00910903
      WBVar00910904
      WBVar00910905
      WBVar02133912
      WBVar00910906
      WBVar00910907
      WBVar02133913
      WBVar00910908
      WBVar02133914
      WBVar02133915
      WBVar00910909
      WBVar02133916
      WBVar00910910
      WBVar02133917
      WBVar00910911
      WBVar01499365
      WBVar00910912
      WBVar02133918
      WBVar00320509
      WBVar02133919
      WBVar01786363
      WBVar01786364
      WBVar00088153
      WBVar00910735
      WBVar00910736
      WBVar00910737
      WBVar00910738
      WBVar00910739
      WBVar00910740
      WBVar00910741
      WBVar00910742
      WBVar00910743
      WBVar00910744
      WBVar00910745
      WBVar00910746
      WBVar00910747
      WBVar00910748
      WBVar00910749
      WBVar00910750
      WBVar00910751
      WBVar00910752
      WBVar00910753
      WBVar00142936
      WBVar00910754
      WBVar00910755
      WBVar00910756
      WBVar01953976
      WBVar01499395
      WBVar00910757
      WBVar01499396
      WBVar00910758
      WBVar01953977
      WBVar00910759
      WBVar00275629
      WBVar01953978
      WBVar00257323
      WBVar00910760
      WBVar00910761
      WBVar00910762
      WBVar01494063
      WBVar00910763
      WBVar00910764
      WBVar00910765
      WBVar00910766
      WBVar00910767
      WBVar00910768
      WBVar00910769
      WBVar00910770
      WBVar00910771
      WBVar00910772
      WBVar00910773
      WBVar00910774
      WBVar01997307
      WBVar00910775
      WBVar01997308
      WBVar00910776
      WBVar00142997
      WBVar00910777
      WBVar00910778
      WBVar00910779
      WBVar00910780
      WBVar00145228
      WBVar00910781
      WBVar00910782
      WBVar00145234
      WBVar00910783
      WBVar00910784
      WBVar00910785
      WBVar01710247
      WBVar00910786
      WBVar00910787
      WBVar01499242
      WBVar00910788
      WBVar00910789
      WBVar00910790
      WBVar00910791
      WBVar00145258
      WBVar00910792
      WBVar00910793
      WBVar00910794
      WBVar01569670
      WBVar01569671
      WBVar00910795
      WBVar01569672
      WBVar02046038
      WBVar00910796
      WBVar01569673
      WBVar00910797
      WBVar00910798
      WBVar00910799
      WBVar00910800
      WBVar00910801
      WBVar00910802
      WBVar00425272
      WBVar01515879
      WBVar00425273
      WBVar01515880
      WBVar00910803
      WBVar00910804
      WBVar00425274
      WBVar01515881
      WBVar00425275
      WBVar01515882
      WBVar00910805
      WBVar01515883
      WBVar00425276
      WBVar00910806
      WBVar01515884
      WBVar00910807
      WBVar00425277
      WBVar01649919
      WBVar01515885
      WBVar00425278
      WBVar00910808
      WBVar00425279
      WBVar01515886
      WBVar00910809
      WBVar01649920
      WBVar00910810
      WBVar01649921
      WBVar00425280
      WBVar01515887
      WBVar02074822
      WBVar01499633
      WBVar00425281
      WBVar01515888
      WBVar01649922
      WBVar00910811
      WBVar00425282
      WBVar00910812
      WBVar01515889
      WBVar00425283
      WBVar00910813
      WBVar00425284
      WBVar00910814
      WBVar00910815
      WBVar00425285
      WBVar00910816
      WBVar01452483
      WBVar00425286
      WBVar00425287
      WBVar01452484
      WBVar00910817
      WBVar00910818
      WBVar01687946
      WBVar01452485
      WBVar00425288
      WBVar00910819
      WBVar01452486
      WBVar00425289
      WBVar02148167
      WBVar01452487
      WBVar00425290
      WBVar00910820
      WBVar01452488
      WBVar00425291
      WBVar00910821
      WBVar01966288
      WBVar00425292
      WBVar01452489
      WBVar00910822
      WBVar01452490
      WBVar00425293
      WBVar00910823
      WBVar01966289
      WBVar01452491
      WBVar00910824
      WBVar00425294
      WBVar00425295
      WBVar00910825
      WBVar01452492
      WBVar01452493
      WBVar00910826
      WBVar00425296
      WBVar01772244
      WBVar00910827
      WBVar01452494
      WBVar00425297
      WBVar00910828
      WBVar00425298
      WBVar01452495
      WBVar00910829
      WBVar00425299
      WBVar00910830
      WBVar00425300
      WBVar00910831
      WBVar00425301
      WBVar00910832
      WBVar00425302
      WBVar00425303
      WBVar00910833
      WBVar00425304
      WBVar00910834
      WBVar00425305
      WBVar00910835
      WBVar00425306
      WBVar00910836
      WBVar00910837
      WBVar00425307
      WBVar00425308
      WBVar00910838
      WBVar00322363
      WBVar00425309
      WBVar00910839
      WBVar00425310
      WBVar00910840
      WBVar01727724
      WBVar00910841
      WBVar00425311
      WBVar00425312
      WBVar00910842
      WBVar00425313
      WBVar00910843
      WBVar00910844
      WBVar00425314
      WBVar00910845
      WBVar00425315
      WBVar00314963
      WBVar00910846
      WBVar00425316
      WBVar00910847
      WBVar00425317
      WBVar00425318
      WBVar00910848
      WBVar00910849
      WBVar00425319
      WBVar00910850
      WBVar00425320
      WBVar00425321
      WBVar00910851
      WBVar00910852
      WBVar00910853
      WBVar00910854
      WBVar00910855
      WBVar00189034
      WBVar00189035
      WBVar00910856
      WBVar00143294
      WBVar00910857
      WBVar00910858
      WBVar00910859
      WBVar00910860
      WBVar00910861
      WBVar00910862
      WBVar00910863
      WBVar00910864
      WBVar00910865
      WBVar00910866
      WBVar00910867
      WBVar00910868
      WBVar00910869
      WBVar00910870
      WBVar00910871
      WBVar01500245
      WBVar00910872
      WBVar00910873
      WBVar00910874
      WBVar01923372
      WBVar00910875
      WBVar01923373
      WBVar00910876
      WBVar00910877
    Legacy_information: e53 : severe coiler grows well; L1 also severe coiler; dorsal hypodermal cells abnormal dorsal nerve cord absent or almost absent cord commissures fail to reach targets muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; Egl-c. ES3 ME0. NA7 (e553 (resemble e53) e152 (weaker phenotype behaviorally and anatomically dorsal cord partially formed) etc.).
      See also e2349, e2355, e2387
      [C.elegansII] e53 : severe coiler, grows well; L1 also severe coiler; dorsal hypodermal cells abnormal, dorsal nerve cord absent or almost absent, cord commissures fail to reach targets; muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; abnormal gonad arms;Egl-c. ES3 ME0. OA>10: e553 (resembles e53), e152 (weaker phenotype behaviorally and anatomically, dorsal cord partially formed), bx8, ev447,st1001tci, etc. See also unc-6, unc-40. Cloned: 3.0 and 3.1 kb transcripts (different 5') ,encode predicted 919 aa transmembrane protein,2 Ig domains and 2 TSP domains. Mosaic analysis indicates autonomous action in neurons, DTC; ectopic expression in touch cells can cause their dorsalward migration. [Hedgecock et al. 1990; Leung-Hagesteijn et al. 1992; Hamelin et al. 1993; NW]
    Strain (67)
    RNASeq_FPKM (74)
    GO_annotation: 00079406
      00079407
      00079408
      00079409
      00079410
      00079411
      00079412
      00079413
      00079414
      00079415
      00079416
      00079417
      00079418
      00079419
      00079420
      00079421
      00079422
      00079423
      00079424
      00079425
      00079426
      00079427
      00079428
      00079429
      00079430
      00079431
      00079432
      00079433
      00079434
      00079435
      00079436
      00079437
      00079438
      00079439
      00079440
      00079441
      00079442
      00079443
      00079444
      00079445
      00079446
      00079447
      00079448
      00079449
      00079450
      00079451
      00079452
      00079453
      00079454
      00114731
      00114732
      00114733
      00114734
    Ortholog (53)
    Structured_description: Concise_description: unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood. Paper_evidence: WBPaper00001619
            WBPaper00005582
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 25 Jan 2006 00:00:00
      Automated_description: Enables netrin receptor activity and protein tyrosine kinase binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and sex differentiation. Acts upstream of or within distal tip cell migration. Located in axonal growth cone. Expressed in several structures, including distal tip cell; excretory canal; head neurons; motor neurons; and somatic nervous system. Is an ortholog of human UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: B0273.4a
      B0273.4b
      B0273.4c
      B0273.4d
      B0273.4e
      B0273.4f
    Corresponding_CDS_history: B0273.4b:wp134
    Corresponding_transcript: B0273.4a.1
      B0273.4b.1
      B0273.4c.1
      B0273.4d.1
      B0273.4d.2
      B0273.4e.1
      B0273.4f.1
    Other_sequence: JI475712.1
      JI459463.1
      CR01727
      CRC00510_2
      CRC06468_1
      CR03346
      CJC11776_1
      JI165198.1
      Dviv_isotig23366
    Associated_feature (24)
  Experimental_info: RNAi_result (14)
    Expr_pattern (11)
    Drives_construct (17)
    Construct_product (13)
    Microarray_results (30)
    Expression_cluster (154)
    Interaction (206)
    WBProcess: WBbiopr:00000025
  Map_info: Map: IV Position: 1.78303 Error: 0.002438
    Well_ordered
    Positive: Positive_clone: B0273 Inferred_automatically: From sequence, transcript, pseudogene data
        C37G6 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: nDp5
    Mapping_data: 2_point (21)
      Multi_point (96)
      Pos_neg_data: 3700
        9031
        9036
        10892
    Landmark_gene
  Reference (341)
  Remark: [Culotti J] The unc-5 expression pattern is now published in Su et al., Development 127,585-594 (2000)
  Method: Gene