WormBase Tree Display for Gene: WBGene00006745

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WBGene00006745	SMap	S_parent	Sequence	B0273
	Identity	Version	1
		Name	CGC_name	unc-5	Person_evidence	WBPerson261
			Sequence_name	B0273.4
			Molecular_name (19)
			Other_name	CELE_B0273.4	Accession_evidence	NDB	BX284604
			Public_name	unc-5
		DB_info	Database	AceView	gene	4G260
				WormQTL	gene	WBGene00006745
				WormFlux	gene	WBGene00006745
				NDB	locus_tag	CELE_B0273.4
				Panther	gene	CAEEL\|WormBase=WBGene00006745\|UniProtKB=Q26261
					family	PTHR12582
				NCBI	gene	177334
				RefSeq	protein	NM_001392311.1
						NM_068422.6
						NM_001306822.3
						NM_068421.6
						NM_001306820.3
						NM_001380233.1
				SwissProt	UniProtAcc	Q26261
				TREEFAM	TREEFAM_ID	TF316767
				UniProt_GCRP	UniProtAcc	Q26261
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:41	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	unc
		Reference_allele	WBVar00142936
		Allele (350)
		Legacy_information	e53 : severe coiler grows well; L1 also severe coiler; dorsal hypodermal cells abnormal dorsal nerve cord absent or almost absent cord commissures fail to reach targets muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; Egl-c. ES3 ME0. NA7 (e553 (resemble e53) e152 (weaker phenotype behaviorally and anatomically dorsal cord partially formed) etc.).
			See also e2349, e2355, e2387
			[C.elegansII] e53 : severe coiler, grows well; L1 also severe coiler; dorsal hypodermal cells abnormal, dorsal nerve cord absent or almost absent, cord commissures fail to reach targets; muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; abnormal gonad arms;Egl-c. ES3 ME0. OA>10: e553 (resembles e53), e152 (weaker phenotype behaviorally and anatomically, dorsal cord partially formed), bx8, ev447,st1001tci, etc. See also unc-6, unc-40. Cloned: 3.0 and 3.1 kb transcripts (different 5') ,encode predicted 919 aa transmembrane protein,2 Ig domains and 2 TSP domains. Mosaic analysis indicates autonomous action in neurons, DTC; ectopic expression in touch cells can cause their dorsalward migration. [Hedgecock et al. 1990; Leung-Hagesteijn et al. 1992; Hamelin et al. 1993; NW]
		Strain (67)
		RNASeq_FPKM (74)
		GO_annotation	00079406
			00079407
			00079408
			00079409
			00079410
			00079411
			00079412
			00079413
			00079414
			00079415
			00079416
			00079417
			00079418
			00079419
			00079420
			00079421
			00079422
			00079423
			00079424
			00079425
			00079426
			00079427
			00079428
			00079429
			00079430
			00079431
			00079432
			00079433
			00079434
			00079435
			00079436
			00079437
			00079438
			00079439
			00079440
			00079441
			00079442
			00079443
			00079444
			00079445
			00079446
			00079447
			00079448
			00079449
			00079450
			00079451
			00079452
			00079453
			00079454
			00114731
			00114732
			00114733
			00114734
		Ortholog (53)
		Structured_description	Concise_description	unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood.	Paper_evidence	WBPaper00001619
						WBPaper00005582
					Curator_confirmed	WBPerson1843
						WBPerson567
					Date_last_updated	25 Jan 2006 00:00:00
			Automated_description	Enables netrin receptor activity and protein tyrosine kinase binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and sex differentiation. Acts upstream of or within distal tip cell migration. Located in axonal growth cone. Expressed in several structures, including distal tip cell; excretory canal; head neurons; motor neurons; and somatic nervous system. Is an ortholog of human UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	B0273.4a
			B0273.4b
			B0273.4c
			B0273.4d
			B0273.4e
			B0273.4f
		Corresponding_CDS_history	B0273.4b:wp134
		Corresponding_transcript	B0273.4a.1
			B0273.4b.1
			B0273.4c.1
			B0273.4d.1
			B0273.4d.2
			B0273.4e.1
			B0273.4f.1
		Other_sequence	JI475712.1
			JI459463.1
			CR01727
			CRC00510_2
			CRC06468_1
			CR03346
			CJC11776_1
			JI165198.1
			Dviv_isotig23366
		Associated_feature (24)
	Experimental_info	RNAi_result (14)
		Expr_pattern (11)
		Drives_construct (17)
		Construct_product (13)
		Microarray_results (30)
		Expression_cluster (154)
		Interaction	WBInteraction000000332
			WBInteraction000000591
			WBInteraction000000592
			WBInteraction000000593
			WBInteraction000000594
			WBInteraction000000595
			WBInteraction000000596
			WBInteraction000000882
			WBInteraction000001390
			WBInteraction000001678
			WBInteraction000001993
			WBInteraction000002056
			WBInteraction000002057
			WBInteraction000002058
			WBInteraction000002060
			WBInteraction000002062
			WBInteraction000002145
			WBInteraction000002433
			WBInteraction000003293
			WBInteraction000003294
			WBInteraction000003308
			WBInteraction000003309
			WBInteraction000003440
			WBInteraction000003441
			WBInteraction000005320
			WBInteraction000005321
			WBInteraction000005410
			WBInteraction000005416
			WBInteraction000008895
			WBInteraction000008896
			WBInteraction000009312
			WBInteraction000009328
			WBInteraction000009548
			WBInteraction000009732
			WBInteraction000028398
			WBInteraction000028568
			WBInteraction000028658
			WBInteraction000028752
			WBInteraction000028753
			WBInteraction000028845
			WBInteraction000029334
			WBInteraction000029419
			WBInteraction000030133
			WBInteraction000030449
			WBInteraction000031880
			WBInteraction000035741
			WBInteraction000043327
			WBInteraction000043468
			WBInteraction000047923
			WBInteraction000048807
			WBInteraction000049330
			WBInteraction000049333
			WBInteraction000050541
			WBInteraction000052637
			WBInteraction000052640
			WBInteraction000052643
			WBInteraction000052646
			WBInteraction000052771
			WBInteraction000052828
			WBInteraction000052839
			WBInteraction000114215
			WBInteraction000126309
			WBInteraction000126310
			WBInteraction000126311
			WBInteraction000126312
			WBInteraction000126313
			WBInteraction000126314
			WBInteraction000126315
			WBInteraction000126316
			WBInteraction000126317
			WBInteraction000126318
			WBInteraction000126319
			WBInteraction000126799
			WBInteraction000126839
			WBInteraction000126840
			WBInteraction000126841
			WBInteraction000126842
			WBInteraction000127413
			WBInteraction000133583
			WBInteraction000133810
			WBInteraction000135189
			WBInteraction000135190
			WBInteraction000135191
			WBInteraction000135720
			WBInteraction000138487
			WBInteraction000139358
			WBInteraction000152155
			WBInteraction000152156
			WBInteraction000161585
			WBInteraction000166377
			WBInteraction000166378
			WBInteraction000166379
			WBInteraction000166380
			WBInteraction000166381
			WBInteraction000166382
			WBInteraction000166383
			WBInteraction000166384
			WBInteraction000189464
			WBInteraction000189465
			WBInteraction000232224
			WBInteraction000243034
			WBInteraction000243035
			WBInteraction000243036
			WBInteraction000243037
			WBInteraction000243038
			WBInteraction000246097
			WBInteraction000246098
			WBInteraction000251953
			WBInteraction000261711
			WBInteraction000261831
			WBInteraction000276149
			WBInteraction000290889
			WBInteraction000336532
			WBInteraction000387381
			WBInteraction000393798
			WBInteraction000393799
			WBInteraction000393800
			WBInteraction000393801
			WBInteraction000393802
			WBInteraction000454913
			WBInteraction000454914
			WBInteraction000454915
			WBInteraction000468716
			WBInteraction000468717
			WBInteraction000468718
			WBInteraction000468719
			WBInteraction000469448
			WBInteraction000500380
			WBInteraction000500381
			WBInteraction000500385
			WBInteraction000500931
			WBInteraction000501811
			WBInteraction000501812
			WBInteraction000503565
			WBInteraction000503768
			WBInteraction000503769
			WBInteraction000504097
			WBInteraction000517893
			WBInteraction000518995
			WBInteraction000519441
			WBInteraction000519714
			WBInteraction000523861
			WBInteraction000535488
			WBInteraction000538511
			WBInteraction000538512
			WBInteraction000538513
			WBInteraction000538514
			WBInteraction000538515
			WBInteraction000538516
			WBInteraction000538517
			WBInteraction000538518
			WBInteraction000538519
			WBInteraction000538520
			WBInteraction000538521
			WBInteraction000538522
			WBInteraction000538523
			WBInteraction000538524
			WBInteraction000538525
			WBInteraction000538527
			WBInteraction000538528
			WBInteraction000538529
			WBInteraction000538530
			WBInteraction000538531
			WBInteraction000538532
			WBInteraction000538533
			WBInteraction000538534
			WBInteraction000538535
			WBInteraction000538536
			WBInteraction000538537
			WBInteraction000538538
			WBInteraction000538539
			WBInteraction000538540
			WBInteraction000538541
			WBInteraction000538543
			WBInteraction000538544
			WBInteraction000538545
			WBInteraction000538546
			WBInteraction000538547
			WBInteraction000538548
			WBInteraction000538549
			WBInteraction000538550
			WBInteraction000538551
			WBInteraction000538552
			WBInteraction000538553
			WBInteraction000538554
			WBInteraction000538555
			WBInteraction000538556
			WBInteraction000538557
			WBInteraction000538558
			WBInteraction000540356
			WBInteraction000540649
			WBInteraction000540981
			WBInteraction000554867
			WBInteraction000555699
			WBInteraction000555967
			WBInteraction000556878
			WBInteraction000557903
			WBInteraction000558060
			WBInteraction000558061
			WBInteraction000558590
			WBInteraction000558591
			WBInteraction000558593
			WBInteraction000558594
			WBInteraction000558595
			WBInteraction000558596
			WBInteraction000560573
		WBProcess	WBbiopr:00000025
	Map_info	Map	IV	Position	1.78303	Error	0.002438
		Well_ordered
		Positive	Positive_clone	B0273	Inferred_automatically	From sequence, transcript, pseudogene data
				C37G6	Inferred_automatically	From sequence, transcript, pseudogene data
		Negative	Outside_rearr	nDp5
		Mapping_data	2_point (21)
			Multi_point (96)
			Pos_neg_data	3700
				9031
				9036
				10892
		Landmark_gene
	Reference (341)
	Remark	[Culotti J] The unc-5 expression pattern is now published in Su et al., Development 127,585-594 (2000)
	Method	Gene