WormBase Tree Display for Gene: WBGene00006745
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WBGene00006745 | SMap | S_parent | Sequence | B0273 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | unc | |||||
Reference_allele | WBVar00142936 | |||||
Allele (350) | ||||||
Legacy_information | e53 : severe coiler grows well; L1 also severe coiler; dorsal hypodermal cells abnormal dorsal nerve cord absent or almost absent cord commissures fail to reach targets muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; Egl-c. ES3 ME0. NA7 (e553 (resemble e53) e152 (weaker phenotype behaviorally and anatomically dorsal cord partially formed) etc.). | |||||
See also e2349, e2355, e2387 | ||||||
[C.elegansII] e53 : severe coiler, grows well; L1 also severe coiler; dorsal hypodermal cells abnormal, dorsal nerve cord absent or almost absent, cord commissures fail to reach targets; muscle arms misdirected; distribution of cell bodies in ventral cord is disorganized; abnormal gonad arms;Egl-c. ES3 ME0. OA>10: e553 (resembles e53), e152 (weaker phenotype behaviorally and anatomically, dorsal cord partially formed), bx8, ev447,st1001tci, etc. See also unc-6, unc-40. Cloned: 3.0 and 3.1 kb transcripts (different 5') ,encode predicted 919 aa transmembrane protein,2 Ig domains and 2 TSP domains. Mosaic analysis indicates autonomous action in neurons, DTC; ectopic expression in touch cells can cause their dorsalward migration. [Hedgecock et al. 1990; Leung-Hagesteijn et al. 1992; Hamelin et al. 1993; NW] | ||||||
Strain (67) | ||||||
RNASeq_FPKM (74) | ||||||
GO_annotation (53) | ||||||
Ortholog (53) | ||||||
Structured_description | Concise_description | unc-5 encodes a netrin receptor; unc-5 activity is required cell autonomously for dorsalward cell and pioneer motor axon migrations along the body wall that are essential for normal locomotion and gonad development; unc-5 mRNAs are expressed throughout the entire life cycle, with increasing levels seen as animals progess to adulthood. | Paper_evidence | WBPaper00001619 | ||
WBPaper00005582 | ||||||
Curator_confirmed | WBPerson1843 | |||||
WBPerson567 | ||||||
Date_last_updated | 25 Jan 2006 00:00:00 | |||||
Automated_description | Enables netrin receptor activity and protein tyrosine kinase binding activity. Involved in several processes, including axon guidance; regulation of neuron projection development; and sex differentiation. Acts upstream of or within distal tip cell migration. Located in axonal growth cone. Expressed in several structures, including distal tip cell; excretory canal; head neurons; motor neurons; and somatic nervous system. Is an ortholog of human UNC5A (unc-5 netrin receptor A); UNC5B (unc-5 netrin receptor B); and UNC5C (unc-5 netrin receptor C). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Molecular_info | Corresponding_CDS | B0273.4a | ||||
B0273.4b | ||||||
B0273.4c | ||||||
B0273.4d | ||||||
B0273.4e | ||||||
B0273.4f | ||||||
Corresponding_CDS_history | B0273.4b:wp134 | |||||
Corresponding_transcript | B0273.4a.1 | |||||
B0273.4b.1 | ||||||
B0273.4c.1 | ||||||
B0273.4d.1 | ||||||
B0273.4d.2 | ||||||
B0273.4e.1 | ||||||
B0273.4f.1 | ||||||
Other_sequence | JI475712.1 | |||||
JI459463.1 | ||||||
CR01727 | ||||||
CRC00510_2 | ||||||
CRC06468_1 | ||||||
CR03346 | ||||||
CJC11776_1 | ||||||
JI165198.1 | ||||||
Dviv_isotig23366 | ||||||
Associated_feature (24) | ||||||
Experimental_info | RNAi_result (14) | |||||
Expr_pattern (11) | ||||||
Drives_construct (17) | ||||||
Construct_product (13) | ||||||
Microarray_results (30) | ||||||
Expression_cluster (154) | ||||||
Interaction (206) | ||||||
WBProcess | WBbiopr:00000025 | |||||
Map_info (6) | ||||||
Reference (341) | ||||||
Remark | [Culotti J] The unc-5 expression pattern is now published in Su et al., Development 127,585-594 (2000) | |||||
Method | Gene |