WormBase Tree Display for Gene: WBGene00006754
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| WBGene00006754 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-15 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F07A5.7 | ||||||||
| Molecular_name | F07A5.7a | ||||||||
| F07A5.7a.1 | |||||||||
| CE09197 | |||||||||
| F07A5.7b | |||||||||
| CE42754 | |||||||||
| F07A5.7a.2 | |||||||||
| F07A5.7b.1 | |||||||||
| Other_name | CELE_F07A5.7 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | unc-15 | ||||||||
| DB_info | Database | AceView | gene | 1H954 | |||||
| WormQTL | gene | WBGene00006754 | |||||||
| WormFlux | gene | WBGene00006754 | |||||||
| NDB | locus_tag | CELE_F07A5.7 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006754|UniProtKB=P10567 | |||||||
| family | PTHR34491 | ||||||||
| NCBI | gene | 172491 | |||||||
| RefSeq | protein | NM_001380695.1 | |||||||
| NM_001392551.1 | |||||||||
| SwissProt | UniProtAcc | P10567 | |||||||
| TREEFAM | TREEFAM_ID | TF336753 | |||||||
| UniProt_GCRP | UniProtAcc | P10567 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00142948 | ||||||||
| Allele (104) | |||||||||
| Legacy_information | Probable structural gene for paramyosin. Reference allele e73 : limp paralysed phenotype larvae move slightly better Egl; disorganized muscle structure; suppressed by sup-3; e73/+ slightly slow. ES3 ME0. NA > 5 (e1214amber (more severe phenotype than e73 not suppressed by sup-3) e1402ts (moves well at 15x paralysed at 25x) etc.). | ||||||||
| See also e1214, e1215, e1461, s40 | |||||||||
| [C.elegansII] e73 : limp paralysed phenotype, larvae move slightly better; Egl; disorganized muscle structure; suppressed by sup-3; e73/+ slightly slow. ES3 ME0. OA>10: e1214amb (more severe phenotype than e73, not suppressed by sup-3), e1402ts (moves well at 15C, paralysed at 25C), ut37 (lethal embryonic arrest at 4-fold stage), r404, r408, m81, s40, su228 etc. Cloned: encodes 886 aa paramyosin. Extensive structural analysis. [Kagawa et al. 1989; Gengyo-Ando and Kagawa 1991; Epstein et al. 1993; HE; HK] | |||||||||
| Strain (43) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (30) | |||||||||
| Paralog (21) | |||||||||
| Structured_description | Concise_description | The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants. | Paper_evidence | WBPaper00004378 | |||||
| WBPaper00005940 | |||||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 17 Jun 2004 00:00:00 | ||||||||
| Automated_description | Enables SH3 domain binding activity; cytoskeletal protein binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of ovulation; positive regulation of sarcomere organization; and skeletal muscle myosin thick filament assembly. Located in A band and myosin filament. Expressed in alimentary muscle; body wall musculature; gonad; vulval muscle; and in male. Is an ortholog of human MYH16 (myosin heavy chain 16 (pseudogene)). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | F07A5.7a | |||||||
| F07A5.7b | |||||||||
| Corresponding_transcript | F07A5.7a.1 | ||||||||
| F07A5.7a.2 | |||||||||
| F07A5.7b.1 | |||||||||
| Other_sequence (227) | |||||||||
| Associated_feature (23) | |||||||||
| Experimental_info | RNAi_result (26) | ||||||||
| Expr_pattern | Expr721 | ||||||||
| Expr722 | |||||||||
| Expr4550 | |||||||||
| Expr1011497 | |||||||||
| Expr1032828 | |||||||||
| Expr1147828 | |||||||||
| Expr2017850 | |||||||||
| Expr2035986 | |||||||||
| Drives_construct | WBCnstr00034170 | ||||||||
| Construct_product | WBCnstr00015355 | ||||||||
| WBCnstr00034170 | |||||||||
| Antibody | WBAntibody00000045 | ||||||||
| WBAntibody00000052 | |||||||||
| WBAntibody00000053 | |||||||||
| WBAntibody00000077 | |||||||||
| WBAntibody00000078 | |||||||||
| WBAntibody00000079 | |||||||||
| WBAntibody00001519 | |||||||||
| Microarray_results (34) | |||||||||
| Expression_cluster (262) | |||||||||
| Interaction (117) | |||||||||
| Map_info | Map | I | Position | 2.0562 | |||||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDp4 | |||||||
| Positive_clone | F07A5 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| HK5 | |||||||||
| Negative | Outside_rearr | qDf16 | |||||||
| Mapping_data | 2_point | 13 | |||||||
| 238 | |||||||||
| 516 | |||||||||
| 1017 | |||||||||
| 6044 | |||||||||
| Multi_point (24) | |||||||||
| Pos_neg_data | 515 | ||||||||
| 2518 | |||||||||
| 4992 | |||||||||
| 4999 | |||||||||
| 5003 | |||||||||
| 5345 | |||||||||
| 954 | |||||||||
| 1025 | |||||||||
| 9395 | |||||||||
| Reference (162) | |||||||||
| Remark | [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (2.04938) | ||||||||
| Method | Gene |
