WBGene00006754 | SMap | S_parent | Sequence | CHROMOSOME_I |
| Identity | Version | 1 |
| | Name | CGC_name | unc-15 | Person_evidence | WBPerson261 |
| | | Sequence_name | F07A5.7 |
| | | Molecular_name | F07A5.7a |
| | | | F07A5.7a.1 |
| | | | CE09197 |
| | | | F07A5.7b |
| | | | CE42754 |
| | | | F07A5.7a.2 |
| | | | F07A5.7b.1 |
| | | Other_name | CELE_F07A5.7 | Accession_evidence | NDB | BX284601 |
| | | Public_name | unc-15 |
| | DB_info | Database | AceView | gene | 1H954 |
| | | | WormQTL | gene | WBGene00006754 |
| | | | WormFlux | gene | WBGene00006754 |
| | | | NDB | locus_tag | CELE_F07A5.7 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006754|UniProtKB=P10567 |
| | | | | family | PTHR34491 |
| | | | NCBI | gene | 172491 |
| | | | RefSeq | protein | NM_001380695.1 |
| | | | | | NM_001392551.1 |
| | | | SwissProt | UniProtAcc | P10567 |
| | | | TREEFAM | TREEFAM_ID | TF336753 |
| | | | UniProt_GCRP | UniProtAcc | P10567 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00142948 |
| | Allele (104) |
| | Legacy_information | Probable structural gene for paramyosin. Reference allele e73 : limp paralysed phenotype larvae move slightly better Egl; disorganized muscle structure; suppressed by sup-3; e73/+ slightly slow. ES3 ME0. NA > 5 (e1214amber (more severe phenotype than e73 not suppressed by sup-3) e1402ts (moves well at 15x paralysed at 25x) etc.). |
| | | See also e1214, e1215, e1461, s40 |
| | | [C.elegansII] e73 : limp paralysed phenotype, larvae move slightly better; Egl; disorganized muscle structure; suppressed by sup-3; e73/+ slightly slow. ES3 ME0. OA>10: e1214amb (more severe phenotype than e73, not suppressed by sup-3), e1402ts (moves well at 15C, paralysed at 25C), ut37 (lethal embryonic arrest at 4-fold stage), r404, r408, m81, s40, su228 etc. Cloned: encodes 886 aa paramyosin. Extensive structural analysis. [Kagawa et al. 1989; Gengyo-Ando and Kagawa 1991; Epstein et al. 1993; HE; HK] |
| | Strain (43) |
| | RNASeq_FPKM (74) |
| | GO_annotation (19) |
| | Ortholog (30) |
| | Paralog (21) |
| | Structured_description | Concise_description | The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants. | Paper_evidence | WBPaper00004378 |
| | | | | | WBPaper00005940 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables SH3 domain binding activity; cytoskeletal protein binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of ovulation; positive regulation of sarcomere organization; and skeletal muscle myosin thick filament assembly. Located in A band and myosin filament. Expressed in alimentary muscle; body wall musculature; gonad; vulval muscle; and in male. Is an ortholog of human MYH16 (myosin heavy chain 16 (pseudogene)). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F07A5.7a |
| | | F07A5.7b |
| | Corresponding_transcript | F07A5.7a.1 |
| | | F07A5.7a.2 |
| | | F07A5.7b.1 |
| | Other_sequence (227) |
| | Associated_feature (23) |
| Experimental_info | RNAi_result (26) |
| | Expr_pattern | Expr721 |
| | | Expr722 |
| | | Expr4550 |
| | | Expr1011497 |
| | | Expr1032828 |
| | | Expr1147828 |
| | | Expr2017850 |
| | | Expr2035986 |
| | Drives_construct | WBCnstr00034170 |
| | Construct_product | WBCnstr00015355 |
| | | WBCnstr00034170 |
| | Antibody | WBAntibody00000045 |
| | | WBAntibody00000052 |
| | | WBAntibody00000053 |
| | | WBAntibody00000077 |
| | | WBAntibody00000078 |
| | | WBAntibody00000079 |
| | | WBAntibody00001519 |
| | Microarray_results (34) |
| | Expression_cluster | WBPaper00027022:tax-6(jh107)_upregulated |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032528:L3_enriched |
| | | WBPaper00033208:STI-1_interacting |
| | | WBPaper00034761:hlh-30_downregulated |
| | | WBPaper00037047:insoluble_protein |
| | | WBPaper00037950:bodywall-muscle_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038118:stress_upregulated_N2 |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040134:nhr-49(RNAi)_regulated_protein |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00043951:insoluble_protein_day16_N2 |
| | | WBPaper00044128:daf-2(e1370)_upregulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_Day5 |
| | | WBPaper00044746:aging_downregulated_Day10 |
| | | WBPaper00044746:aging_downregulated_HeatShock |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046217:mev-1(kn1)_upregulated |
| | | WBPaper00046446:slow-synthesized_YoungAdult |
| | | WBPaper00046496:Rifampicin_downregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00046741:Garlic-Extract_downregulated_protein |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048910:mRNA-interacting_protein |
| | | WBPaper00048988:daf-2(e1370)_daf-16(mu86)_upregulated_neuron |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049498:npr-1(ur89)_regulated_3 |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo |
| | | WBPaper00050182:lmn-1(L535P)_downregulated |
| | | WBPaper00050234:lin-28(RNAi)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050686:glp-1(e2141)_upregulated |
| | | WBPaper00050698:DEP-1_interacting |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:ash-2(RNAi)_regulated_intestine |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:cytoplasm_specific |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051538:micro-gavity_downregulated_protein |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053254:hsp-90(RNAi)_upregulated_protein |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053318:Aging_downregulated_mRNA_N2 |
| | | WBPaper00053321:mes-4(RNAi)_downregulated_fed-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00053814:15C_downregulated_PY79 |
| | | WBPaper00054189:P.aeruginosa_regulated_protein |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054996:unactivated_spermatid_CE |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055103:thoc-5(wy822)_downregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055897:heat-shock_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047) |
| | | WBPaper00056218:daf-16(mu86)_upregulated_Day3 |
| | | WBPaper00056443:DietaryRestriction_downregulated |
| | | WBPaper00056900:ERH-2_interacting |
| | | WBPaper00056900:PID-3_interacting |
| | | WBPaper00056900:TOFU-6_interacting |
| | | WBPaper00056900:TOST-1_interacting |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057006:DietaryRestriction_upregulated |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_protein |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058725:sftb-1(cer39)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00058969:RIS_depleted |
| | | WBPaper00059231:alh-6(lax105)_D3Adult_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059728:20ug_cholesterol_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_OP50 |
| | | WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060871:M.humicola-infection_48h_regulated |
| | | WBPaper00060908:TEBP-1_interacting |
| | | WBPaper00061040:FW1256_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061285:wounding_0h_downregulated |
| | | WBPaper00061285:wounding_24h_downregulated |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:MYRF-2_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061466:nath-10(icb99)_upregulated |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061479:hda-1(ne4747)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061479:prg-1(tm872)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:mup-2-unc-87_284 |
| | | WBPaper00061651:hmc_enriched |
| | | WBPaper00061818:AFD_enriched_protein |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00062002:Day4-adult_secretome |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_upregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062498:PPM-1.D_interacting |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_starved |
| | | WBPaper00064055:trl-1(cas1078)_upregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA |
| | | WBPaper00064163:ZNFX-1_interacting_embryo |
| | | WBPaper00064163:ZNFX-1_interacting_young-adult |
| | | WBPaper00064494:postdauer_upregulated_AWA |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064727:daf-2(e1370)_upregulated |
| | | WBPaper00064735:bet-1(uth41)_vs_N2_upregulated |
| | | WBPaper00064933:E.coli-binding_secret_protein |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065623:59 |
| | | WBPaper00065623:143 |
| | | WBPaper00065749:Heat-Shock_upregulated_N2 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day11 |
| | | WBPaper00065841:1_1 |
| | | WBPaper00065841:4_0 |
| | | WBPaper00065841:4_1 |
| | | WBPaper00065841:4_2 |
| | | WBPaper00065841:7_0 |
| | | WBPaper00065841:7_1 |
| | | WBPaper00065841:7_2 |
| | | WBPaper00065841:7_3 |
| | | WBPaper00065841:7_4 |
| | | WBPaper00065841:38_1 |
| | | WBPaper00065841:38_3 |
| | | WBPaper00065841:143_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4386_cluster_2_5 |
| | | cgc4489_group_24 |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_downregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027342:alpha-Synuclein(A53T)_downregulated |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031060:2-deoxy-D-glucose_upregulated |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032062:age_regulated_genes |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_6 |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036286:Pattern_C |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00037695:LD_3-day |
| | | WBPaper00037695:LD_DD_6-day |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040821:Au-NP_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040985:AIN-2_asynchronous_muscle |
| | | WBPaper00041002:HF_3d_0.2mM_Up |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041002:HF_11d_2.0mM_Up |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00042178:hlh-29(tm284)_upregulated |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00048567:dnj-14_upregulated |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | [cgc5767]:cluster_2 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(83_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(83_min) |
| | | [cgc6390]:Cluster_C |
| | | [cgc6390]:male_soma-enriched |
| | Interaction (117) |
| Map_info | Map | I | Position | 2.0562 |
| | Well_ordered |
| | Positive | Inside_rearr | nDp4 |
| | | Positive_clone | F07A5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | HK5 |
| | Negative | Outside_rearr | qDf16 |
| | Mapping_data | 2_point | 13 |
| | | | 238 |
| | | | 516 |
| | | | 1017 |
| | | | 6044 |
| | | Multi_point (24) |
| | | Pos_neg_data | 515 |
| | | | 2518 |
| | | | 4992 |
| | | | 4999 |
| | | | 5003 |
| | | | 5345 |
| | | | 954 |
| | | | 1025 |
| | | | 9395 |
| Reference (162) |
| Remark | [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (2.04938) |
| Method | Gene |