WormBase Tree Display for Gene: WBGene00006754

WBGene00006754 SMap: S_parent: Sequence: CHROMOSOME_I
  Identity: Version: 1
    Name: CGC_name: unc-15 Person_evidence: WBPerson261
      Sequence_name: F07A5.7
      Molecular_name: F07A5.7a
        F07A5.7a.1
        CE09197
        F07A5.7b
        CE42754
        F07A5.7a.2
        F07A5.7b.1
      Other_name: CELE_F07A5.7 Accession_evidence: NDB BX284601
      Public_name: unc-15
    DB_info: Database: AceView gene 1H954
        WormQTL gene WBGene00006754
        WormFlux gene WBGene00006754
        NDB locus_tag CELE_F07A5.7
        Panther gene CAEEL|WormBase=WBGene00006754|UniProtKB=P10567
          family PTHR34491
        NCBI gene 172491
        RefSeq protein NM_001380695.1
            NM_001392551.1
        SwissProt UniProtAcc P10567
        TREEFAM TREEFAM_ID TF336753
        UniProt_GCRP UniProtAcc P10567
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142948
    Allele (104)
    Legacy_information: Probable structural gene for paramyosin. Reference allele e73 : limp paralysed phenotype larvae move slightly better Egl; disorganized muscle structure; suppressed by sup-3; e73/+ slightly slow. ES3 ME0. NA > 5 (e1214amber (more severe phenotype than e73 not suppressed by sup-3) e1402ts (moves well at 15x paralysed at 25x) etc.).
      See also e1214, e1215, e1461, s40
      [C.elegansII] e73 : limp paralysed phenotype, larvae move slightly better; Egl; disorganized muscle structure; suppressed by sup-3; e73/+ slightly slow. ES3 ME0. OA>10: e1214amb (more severe phenotype than e73, not suppressed by sup-3), e1402ts (moves well at 15C, paralysed at 25C), ut37 (lethal embryonic arrest at 4-fold stage), r404, r408, m81, s40, su228 etc. Cloned: encodes 886 aa paramyosin. Extensive structural analysis. [Kagawa et al. 1989; Gengyo-Ando and Kagawa 1991; Epstein et al. 1993; HE; HK]
    Strain (43)
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (30)
    Paralog (21)
    Structured_description: Concise_description: The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants. Paper_evidence: WBPaper00004378
            WBPaper00005940
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables SH3 domain binding activity; cytoskeletal protein binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of ovulation; positive regulation of sarcomere organization; and skeletal muscle myosin thick filament assembly. Located in A band and myosin filament. Expressed in alimentary muscle; body wall musculature; gonad; vulval muscle; and in male. Is an ortholog of human MYH16 (myosin heavy chain 16 (pseudogene)). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F07A5.7a
      F07A5.7b
    Corresponding_transcript: F07A5.7a.1
      F07A5.7a.2
      F07A5.7b.1
    Other_sequence (227)
    Associated_feature (23)
  Experimental_info: RNAi_result (26)
    Expr_pattern: Expr721
      Expr722
      Expr4550
      Expr1011497
      Expr1032828
      Expr1147828
      Expr2017850
      Expr2035986
    Drives_construct: WBCnstr00034170
    Construct_product: WBCnstr00015355
      WBCnstr00034170
    Antibody: WBAntibody00000045
      WBAntibody00000052
      WBAntibody00000053
      WBAntibody00000077
      WBAntibody00000078
      WBAntibody00000079
      WBAntibody00001519
    Microarray_results (34)
    Expression_cluster (262)
    Interaction: WBInteraction000000685
      WBInteraction000001180
      WBInteraction000001286
      WBInteraction000002482
      WBInteraction000002483
      WBInteraction000002485
      WBInteraction000002486
      WBInteraction000002489
      WBInteraction000002511
      WBInteraction000005189
      WBInteraction000005190
      WBInteraction000008081
      WBInteraction000008082
      WBInteraction000008083
      WBInteraction000008084
      WBInteraction000008085
      WBInteraction000008717
      WBInteraction000008821
      WBInteraction000009616
      WBInteraction000029277
      WBInteraction000030394
      WBInteraction000030692
      WBInteraction000031797
      WBInteraction000031887
      WBInteraction000031888
      WBInteraction000044381
      WBInteraction000044382
      WBInteraction000050028
      WBInteraction000121872
      WBInteraction000126314
      WBInteraction000126328
      WBInteraction000134349
      WBInteraction000152967
      WBInteraction000156810
      WBInteraction000166441
      WBInteraction000166510
      WBInteraction000200287
      WBInteraction000203159
      WBInteraction000204125
      WBInteraction000208807
      WBInteraction000212844
      WBInteraction000215164
      WBInteraction000218151
      WBInteraction000218152
      WBInteraction000221749
      WBInteraction000235878
      WBInteraction000253648
      WBInteraction000278441
      WBInteraction000293051
      WBInteraction000297632
      WBInteraction000329480
      WBInteraction000330157
      WBInteraction000335478
      WBInteraction000347453
      WBInteraction000354510
      WBInteraction000356990
      WBInteraction000361987
      WBInteraction000370585
      WBInteraction000384639
      WBInteraction000391078
      WBInteraction000392512
      WBInteraction000409304
      WBInteraction000410971
      WBInteraction000412217
      WBInteraction000421430
      WBInteraction000423098
      WBInteraction000429495
      WBInteraction000435662
      WBInteraction000460661
      WBInteraction000470225
      WBInteraction000503483
      WBInteraction000514954
      WBInteraction000514955
      WBInteraction000516063
      WBInteraction000518394
      WBInteraction000518614
      WBInteraction000518905
      WBInteraction000520570
      WBInteraction000520572
      WBInteraction000520574
      WBInteraction000522846
      WBInteraction000522999
      WBInteraction000523032
      WBInteraction000539476
      WBInteraction000539478
      WBInteraction000542700
      WBInteraction000543132
      WBInteraction000543937
      WBInteraction000544034
      WBInteraction000546581
      WBInteraction000548957
      WBInteraction000550718
      WBInteraction000550730
      WBInteraction000551443
      WBInteraction000556228
      WBInteraction000556633
      WBInteraction000561561
      WBInteraction000561695
      WBInteraction000562131
      WBInteraction000562325
      WBInteraction000562537
      WBInteraction000564377
      WBInteraction000565559
      WBInteraction000566298
      WBInteraction000566577
      WBInteraction000571984
      WBInteraction000572493
      WBInteraction000572728
      WBInteraction000573987
      WBInteraction000576474
      WBInteraction000576952
      WBInteraction000578224
      WBInteraction000578658
      WBInteraction000580478
      WBInteraction000581978
      WBInteraction000585908
      WBInteraction000586535
  Map_info: Map: I Position: 2.0562
    Well_ordered
    Positive: Inside_rearr: nDp4
      Positive_clone: F07A5 Inferred_automatically: From sequence, transcript, pseudogene data
        HK5
    Negative: Outside_rearr: qDf16
    Mapping_data: 2_point: 13
        238
        516
        1017
        6044
      Multi_point (24)
      Pos_neg_data: 515
        2518
        4992
        4999
        5003
        5345
        954
        1025
        9395
  Reference (162)
  Remark: [200811 gw3] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (2.04938)
  Method: Gene