Probable structural gene for paramyosin. Reference allele e73 : limp paralysed phenotype larvae move slightly better Egl; disorganized muscle structure; suppressed by sup-3; e73/+ slightly slow. ES3 ME0. NA > 5 (e1214amber (more severe phenotype than e73 not suppressed by sup-3) e1402ts (moves well at 15x paralysed at 25x) etc.).
See also e1214, e1215, e1461, s40
[C.elegansII] e73 : limp paralysed phenotype, larvae move slightly better; Egl; disorganized muscle structure; suppressed by sup-3; e73/+ slightly slow. ES3 ME0. OA>10: e1214amb (more severe phenotype than e73, not suppressed by sup-3), e1402ts (moves well at 15C, paralysed at 25C), ut37 (lethal embryonic arrest at 4-fold stage), r404, r408, m81, s40, su228 etc. Cloned: encodes 886 aa paramyosin. Extensive structural analysis. [Kagawa et al. 1989; Gengyo-Ando and Kagawa 1991; Epstein et al. 1993; HE; HK]
The unc-15 gene encodes a paramyosin ortholog; UNC-15 protein physically interacts with MHC A, one isoform of myosin heavy chain (MHC) in striated muscle; UNC-15 accumulation is decreased in the absence of UNC-54 (myosin B), implying that degradation of UNC-15 is inhibited by its binding myosin B; conversely, myosin B (but not MYO-3/myosin A) fails to accumulate in unc-15 mutants.
Enables SH3 domain binding activity; cytoskeletal protein binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of ovulation; positive regulation of sarcomere organization; and skeletal muscle myosin thick filament assembly. Located in A band and myosin filament. Expressed in alimentary muscle; body wall musculature; gonad; vulval muscle; and in male. Is an ortholog of human MYH16 (myosin heavy chain 16 (pseudogene)).