WormBase Tree Display for Gene: WBGene00006760

WBGene00006760 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: CHROMOSOME_V
  Identity: Version: 2
    Name: CGC_name: unc-23 Person_evidence: WBPerson261
      Sequence_name: H14N18.1
      Molecular_name: H14N18.1a
        H14N18.1a.1
        CE17973
        H14N18.1b
        CE33124
        H14N18.1c
        CE37777
        H14N18.1b.1
        H14N18.1c.1
      Other_name: vab-4
        bag-2 Paper_evidence: WBPaper00048629
        CELE_H14N18.1 Accession_evidence: NDB BX284605
      Public_name: unc-23
    DB_info: Database: AceView gene 5J419
        WormQTL gene WBGene00006760
        WormFlux gene WBGene00006760
        NDB locus_tag CELE_H14N18.1
        Panther gene CAEEL|WormBase=WBGene00006760|UniProtKB=O61980
          family PTHR12334
        NCBI gene 179272
        RefSeq protein NM_072906.7
            NM_182342.6
            NM_001392570.1
        TREEFAM TREEFAM_ID TF102012
        TrEMBL UniProtAcc Q5TKA9
            Q86S24
            O61980
        UniProt_GCRP UniProtAcc O61980
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 03 Nov 2015 10:56:26 WBPerson2970 Name_change: Other_name: bag-2
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00142919
    Allele (62)
    Legacy_information: e25 : `benthead' progressive dystrophy of head musculature so that adult head is bent dorsally or ventrally hence very poor forward movement good reverse movement. Egl. ES3 (adult) ME1. NA8 (e324 : resembles e25; e611 (pka vab-4 : incompletely penetrant allele) etc.).
      See also e25, e462, e478, e611, e621, e988, e1182, e2154
      [C.elegansII] e25 : "benthead" phenotype, progressive dystrophy of head musculature so that adult head is bent dorsally or ventrally, hence very poor forward movement, good reverse movement; defects in muscle attachment (Mua); Egl. Phenotype partly suppressed by growth in liquid. ES3 (adult) ME1. OA>10: e324 (resembles e25), e611 (pka vab-4, impenetrant allele), e988, e2154 etc. [Waterston et al. 1980; CB; DR; NJ]
    Strain: WBStrain00032000
      WBStrain00033526
      WBStrain00034712
      WBStrain00003976
      WBStrain00003958
      WBStrain00004081
      WBStrain00004149
      WBStrain00004186
      WBStrain00005873
      WBStrain00005890
    RNASeq_FPKM (74)
    GO_annotation (15)
    Ortholog: WBGene00068028 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00038405 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00145688 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00155487 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00135543 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00224911 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g139 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g210 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g5598 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g4624 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g18159 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g17474 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g18145 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g4117 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g23731 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g21448 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00498.g11567 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-unc-23 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g15380 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01502.g21316 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_09690 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_017286 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07290 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g15790 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_50231100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrV_pilon.g15115 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00081679 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00242795 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00091411 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00256117 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00286621 Trichuris muris From_analysis: WormBase-Compara
      FB:FBgn0036505 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            SonicParanoid
      ZFIN:ZDB-GENE-040426-1399 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:938 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      MGI:1891254 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      RGD:1585173 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
    Structured_description: Concise_description: unc-23 encodes a protein with similarity to the BAG2 (BCL2 AnthaGene) protein that functions to negatively regulate proteosomal degradation by the E3 ubiquitin ligase and Hsp70 co-chaperone CHIP (Carboxyl-terminus of Hsp70 Interacting Protein); in C. elegans, unc-23 is required for proper attachment of the anterior body wall musculature to the overlying hypodermis. Paper_evidence: WBPaper00040313
            WBPaper00000461
            WBPaper00003943
          Curator_confirmed: WBPerson1843
          Date_last_updated: 29 Oct 2015 00:00:00
      Automated_description: Enables ATPase activator activity and heat shock protein binding activity. Acts upstream of with a positive effect on muscle attachment. Located in M band; nucleolus; and striated muscle dense body. Expressed in several structures, including anal depressor muscle; excretory canal; pharynx; touch receptor neurons; and vulva. Is an ortholog of human BAG2 (BAG cochaperone 2). Paper_evidence: WBPaper00065943
          Curator_confirmed (2)
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: H14N18.1a
      H14N18.1b
      H14N18.1c
    Corresponding_transcript: H14N18.1a.1
      H14N18.1b.1
      H14N18.1c.1
    Other_sequence (11)
    Associated_feature: WBsf647031
      WBsf647032
      WBsf661014
      WBsf661015
      WBsf661510
      WBsf981973
      WBsf232176
      WBsf232177
      WBsf232178
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr11891
      Expr12480
      Expr1012508
      Expr1032833
      Expr1153142
      Expr2017856
      Expr2035992
    Drives_construct: WBCnstr00019716
      WBCnstr00019717
      WBCnstr00034167
    Construct_product: WBCnstr00021438
      WBCnstr00034167
    Microarray_results (28)
    Expression_cluster (192)
    Interaction (27)
  Map_info: Map: V Position: 1.8633 Error: 0.014042
    Well_ordered
    Positive: Inside_rearr: mDf1
        sDf29
      Positive_clone: H14N18 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: nDf42
    Mapping_data: 2_point: 129
        840
        841
      Multi_point (26)
      Pos_neg_data (12)
  Reference (57)
  Remark: Sequence connection from [Rahmani P, Moerman DG]
  Method: Gene