| WBGene00006762 | SMap | S_parent | Sequence | Y37D8A |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-25 | Person_evidence | WBPerson261 |
| | | Sequence_name | Y37D8A.23 |
| | | Molecular_name | Y37D8A.23a |
| | | | Y37D8A.23a.1 |
| | | | CE20226 |
| | | | Y37D8A.23b |
| | | | CE31832 |
| | | | Y37D8A.23c |
| | | | CE32012 |
| | | | Y37D8A.23b.1 |
| | | | Y37D8A.23c.1 |
| | | Other_name | CELE_Y37D8A.23 | Accession_evidence | NDB | BX284603 |
| | | Public_name | unc-25 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info (12) |
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045914 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 06 Jun 2019 00:00:00 |
| | | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 |
| | | | | Curator_confirmed | WBPerson38202 |
| | | | | Date_last_updated | 04 Jun 2018 00:00:00 |
| | | DOID:0050669 | Homo sapiens | Paper_evidence | WBPaper00024523 |
| | | | | Accession_evidence | OMIM | 603513 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 22 Apr 2013 00:00:00 |
| | Potential_model (12) |
| | Disease_relevance | Mutations in Glutamic acid decarboxylase (GAD1), the human ortholog of elegans unc-25, are associated with autosomal recessive spastic cerebral palsy, a movement disorder caused by abnormalities in the brain; studies in elegans show that unc-25 is required for gamma-amino-butyric acid (GABA) synthesis and GABA-mediated behavioral functions; various GABA mutants in elegans, like unc-25, the GABA vesicular transporters (unc-46 and unc-47), and the GABA-A receptor, unc-49, all present head-bobbing convulsions. | Homo sapiens | Paper_evidence | WBPaper00024523 |
| | | | | | WBPaper00042136 |
| | | | | Accession_evidence | OMIM | 603513 |
| | | | | | | 605363 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 22 Apr 2013 00:00:00 |
| Models_disease_in_annotation | WBDOannot00000163 |
| Models_disease_asserted | WBDOannot00000549 |
| | WBDOannot00000702 |
| | WBDOannot00000703 |
| Molecular_info | Corresponding_CDS | Y37D8A.23a |
| | | Y37D8A.23b |
| | | Y37D8A.23c |
| | Corresponding_transcript | Y37D8A.23a.1 |
| | | Y37D8A.23b.1 |
| | | Y37D8A.23c.1 |
| | Other_sequence (65) |
| | Associated_feature | WBsf645681 |
| | | WBsf994764 |
| | | WBsf994765 |
| | | WBsf1016280 |
| | | WBsf1016281 |
| | | WBsf1016282 |
| | | WBsf225951 |
| | | WBsf225952 |
| Experimental_info | RNAi_result | WBRNAi00090105 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077589 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00077586 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00027872 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089945 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00002293 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00055883 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090263 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089782 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (15) |
| | Drives_construct (136) |
| | Construct_product | WBCnstr00010179 |
| | | WBCnstr00038179 |
| | | WBCnstr00038181 |
| | Regulate_expr_cluster | WBPaper00065734:unc-25(e156)_downregulated |
| | | WBPaper00065734:unc-25(e156)_upregulated |
| | Microarray_results (30) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1678 |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00032425:down_in_zfp-1 |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037946:LIN-39_interacting |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_CoreEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_larva_enriched |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044578:reduced-humidity_downregulated_microarray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(gk119)_downregulated |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045417:128Q-huntingtin_downreglated |
| | | WBPaper00045774:clk-1_upregulated |
| | | WBPaper00046858:elt-2(RNAi)_downregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00055060:flr-1(RNAi)_downregulated |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055827:daf-2(e1370)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056443:DietaryRestriction_downregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058948:npr-8(ok1439)_downregulated_OP50 |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:OLQ |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:RIS |
| | | WBPaper00061340:RME |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection |
| | | WBPaper00061527:R07G3.8_9125-ric-4_17408 |
| | | WBPaper00061651:AVL_enriched |
| | | WBPaper00061651:DVB_enriched |
| | | WBPaper00061651:RIB_enriched |
| | | WBPaper00061651:RIS_enriched |
| | | WBPaper00061651:RME_DV_enriched |
| | | WBPaper00061651:RME_LR_enriched |
| | | WBPaper00061651:VD_DD_enriched |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062520:qui-1(db104)_downregulated |
| | | WBPaper00064130:Beta-Amyloid_downregulated_protein |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00065331:100nM-ivermectin_downregulated |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_downregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | WBPaper00065623:43 |
| | | WBPaper00065623:128 |
| | | WBPaper00065734:unc-25(e156)_downregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:10_0 |
| | | WBPaper00065841:68_0 |
| | | WBPaper00065841:68_1 |
| | | WBPaper00065841:109_0 |
| | | WBPaper00065841:118_0 |
| | | WBPaper00065841:121_0 |
| | | WBPaper00065841:144_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4489_group_19 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00029437:dcr-1_upregulated |
| | | WBPaper00029437:rde-1_upregulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035560:ahr-1_downregulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00036123:Cadmium_regulated |
| | | WBPaper00038427:lin-54_embryo_changed |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040210:Chlorpyrifos_16C_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040876:mir-35_downregulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:control_vs_UVC-exposed_3h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042236:flcn-1(ok975)_upregulated |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00047070:N2_UV_downregulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | WBPaper00048624:hlh-25(ok1710)_upregulated |
| | | WBPaper00048989:N2_rapamycin_upregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc6390]:Cluster_A |
| | Interaction (55) |
| | WBProcess | WBbiopr:00000010 |
| Map_info | Map | III | Position | 20.6616 | Error | 0.04207 |
| | Well_ordered |
| | Positive | Positive_clone | Y37D8A | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 57 |
| | | | 68 |
| | | | 78 |
| | | | 6019 |
| | | | 6109 |
| | | | 7009 |
| | | | 7010 |
| | | Multi_point (42) |
| | | Pos_neg_data | 354 |
| | | | 8378 |
| | | | 8386 |
| | | | 8389 |
| | | | 8550 |
| Reference (216) |
| Method | Gene |
