WormBase Tree Display for Gene: WBGene00006762

WBGene00006762 SMap: S_parent: Sequence: Y37D8A
  Identity: Version: 1
    Name: CGC_name: unc-25 Person_evidence: WBPerson261
      Sequence_name: Y37D8A.23
      Molecular_name: Y37D8A.23a
        Y37D8A.23a.1
        CE20226
        Y37D8A.23b
        CE31832
        Y37D8A.23c
        CE32012
        Y37D8A.23b.1
        Y37D8A.23c.1
      Other_name: CELE_Y37D8A.23 Accession_evidence: NDB BX284603
      Public_name: unc-25
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (12)
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00045914
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 Jun 2019 00:00:00
      DOID:1826 Homo sapiens Paper_evidence: WBPaper00035198
          Curator_confirmed: WBPerson38202
          Date_last_updated: 04 Jun 2018 00:00:00
      DOID:0050669 Homo sapiens Paper_evidence: WBPaper00024523
          Accession_evidence: OMIM 603513
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 Apr 2013 00:00:00
    Potential_model (12)
    Disease_relevance: Mutations in Glutamic acid decarboxylase (GAD1), the human ortholog of elegans unc-25, are associated with autosomal recessive spastic cerebral palsy, a movement disorder caused by abnormalities in the brain; studies in elegans show that unc-25 is required for gamma-amino-butyric acid (GABA) synthesis and GABA-mediated behavioral functions; various GABA mutants in elegans, like unc-25, the GABA vesicular transporters (unc-46 and unc-47), and the GABA-A receptor, unc-49, all present head-bobbing convulsions. Homo sapiens Paper_evidence: WBPaper00024523
            WBPaper00042136
          Accession_evidence: OMIM 603513
              605363
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 Apr 2013 00:00:00
  Models_disease_in_annotation: WBDOannot00000163
  Models_disease_asserted: WBDOannot00000549
    WBDOannot00000702
    WBDOannot00000703
  Molecular_info: Corresponding_CDS: Y37D8A.23a
      Y37D8A.23b
      Y37D8A.23c
    Corresponding_transcript: Y37D8A.23a.1
      Y37D8A.23b.1
      Y37D8A.23c.1
    Other_sequence (65)
    Associated_feature: WBsf645681
      WBsf994764
      WBsf994765
      WBsf1016280
      WBsf1016281
      WBsf1016282
      WBsf225951
      WBsf225952
  Experimental_info: RNAi_result: WBRNAi00090105 Inferred_automatically: RNAi_primary
      WBRNAi00077589 Inferred_automatically: RNAi_primary
      WBRNAi00077586 Inferred_automatically: RNAi_primary
      WBRNAi00027872 Inferred_automatically: RNAi_primary
      WBRNAi00089945 Inferred_automatically: RNAi_primary
      WBRNAi00002293 Inferred_automatically: RNAi_primary
      WBRNAi00055883 Inferred_automatically: RNAi_primary
      WBRNAi00090263 Inferred_automatically: RNAi_primary
      WBRNAi00089782 Inferred_automatically: RNAi_primary
    Expr_pattern (15)
    Drives_construct (136)
    Construct_product: WBCnstr00010179
      WBCnstr00038179
      WBCnstr00038181
    Regulate_expr_cluster: WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065734:unc-25(e156)_upregulated
    Microarray_results (30)
    Expression_cluster (186)
    Interaction: WBInteraction000000832
      WBInteraction000001428
      WBInteraction000002346
      WBInteraction000003251
      WBInteraction000003480
      WBInteraction000003861
      WBInteraction000005840
      WBInteraction000008963
      WBInteraction000008967
      WBInteraction000009233
      WBInteraction000028229
      WBInteraction000028428
      WBInteraction000028732
      WBInteraction000029412
      WBInteraction000030260
      WBInteraction000031893
      WBInteraction000038627
      WBInteraction000040584
      WBInteraction000041787
      WBInteraction000043163
      WBInteraction000045936
      WBInteraction000052836
      WBInteraction000052969
      WBInteraction000126297
      WBInteraction000126460
      WBInteraction000126485
      WBInteraction000126592
      WBInteraction000127178
      WBInteraction000165628
      WBInteraction000165897
      WBInteraction000165899
      WBInteraction000165934
      WBInteraction000166446
      WBInteraction000167433
      WBInteraction000220766
      WBInteraction000227275
      WBInteraction000299279
      WBInteraction000367361
      WBInteraction000376125
      WBInteraction000501209
      WBInteraction000501210
      WBInteraction000501211
      WBInteraction000501212
      WBInteraction000501950
      WBInteraction000517365
      WBInteraction000517573
      WBInteraction000520025
      WBInteraction000524336
      WBInteraction000551748
      WBInteraction000555296
      WBInteraction000558065
      WBInteraction000558066
      WBInteraction000580479
      WBInteraction000583691
      WBInteraction000584070
    WBProcess: WBbiopr:00000010
  Map_info: Map: III Position: 20.6616 Error: 0.04207
    Well_ordered
    Positive: Positive_clone: Y37D8A Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 57
        68
        78
        6019
        6109
        7009
        7010
      Multi_point (42)
      Pos_neg_data: 354
        8378
        8386
        8389
        8550
  Reference (216)
  Method: Gene