WormBase Tree Display for Gene: WBGene00006762

WBGene00006762 SMap: S_parent: Sequence: Y37D8A
  Identity: Version: 1
    Name: CGC_name: unc-25 Person_evidence: WBPerson261
      Sequence_name: Y37D8A.23
      Molecular_name: Y37D8A.23a
        Y37D8A.23a.1
        CE20226
        Y37D8A.23b
        CE31832
        Y37D8A.23c
        CE32012
        Y37D8A.23b.1
        Y37D8A.23c.1
      Other_name: CELE_Y37D8A.23 Accession_evidence: NDB BX284603
      Public_name: unc-25
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info (12)
  Disease_info: Experimental_model: DOID:1574 Homo sapiens Paper_evidence: WBPaper00045914
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 Jun 2019 00:00:00
      DOID:1826 Homo sapiens Paper_evidence: WBPaper00035198
          Curator_confirmed: WBPerson38202
          Date_last_updated: 04 Jun 2018 00:00:00
      DOID:0050669 Homo sapiens Paper_evidence: WBPaper00024523
          Accession_evidence: OMIM 603513
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 Apr 2013 00:00:00
    Potential_model (12)
    Disease_relevance: Mutations in Glutamic acid decarboxylase (GAD1), the human ortholog of elegans unc-25, are associated with autosomal recessive spastic cerebral palsy, a movement disorder caused by abnormalities in the brain; studies in elegans show that unc-25 is required for gamma-amino-butyric acid (GABA) synthesis and GABA-mediated behavioral functions; various GABA mutants in elegans, like unc-25, the GABA vesicular transporters (unc-46 and unc-47), and the GABA-A receptor, unc-49, all present head-bobbing convulsions. Homo sapiens Paper_evidence: WBPaper00024523
            WBPaper00042136
          Accession_evidence: OMIM 603513
              605363
          Curator_confirmed: WBPerson324
          Date_last_updated: 22 Apr 2013 00:00:00
  Models_disease_in_annotation: WBDOannot00000163
  Models_disease_asserted: WBDOannot00000549
    WBDOannot00000702
    WBDOannot00000703
  Molecular_info: Corresponding_CDS: Y37D8A.23a
      Y37D8A.23b
      Y37D8A.23c
    Corresponding_transcript: Y37D8A.23a.1
      Y37D8A.23b.1
      Y37D8A.23c.1
    Other_sequence (65)
    Associated_feature: WBsf645681
      WBsf994764
      WBsf994765
      WBsf1016280
      WBsf1016281
      WBsf1016282
      WBsf225951
      WBsf225952
  Experimental_info: RNAi_result: WBRNAi00090105 Inferred_automatically: RNAi_primary
      WBRNAi00077589 Inferred_automatically: RNAi_primary
      WBRNAi00077586 Inferred_automatically: RNAi_primary
      WBRNAi00027872 Inferred_automatically: RNAi_primary
      WBRNAi00089945 Inferred_automatically: RNAi_primary
      WBRNAi00002293 Inferred_automatically: RNAi_primary
      WBRNAi00055883 Inferred_automatically: RNAi_primary
      WBRNAi00090263 Inferred_automatically: RNAi_primary
      WBRNAi00089782 Inferred_automatically: RNAi_primary
    Expr_pattern (15)
    Drives_construct (136)
    Construct_product: WBCnstr00010179
      WBCnstr00038179
      WBCnstr00038181
    Regulate_expr_cluster: WBPaper00065734:unc-25(e156)_downregulated
      WBPaper00065734:unc-25(e156)_upregulated
    Microarray_results (30)
    Expression_cluster (186)
    Interaction (55)
    WBProcess: WBbiopr:00000010
  Map_info: Map: III Position: 20.6616 Error: 0.04207
    Well_ordered
    Positive: Positive_clone: Y37D8A Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 57
        68
        78
        6019
        6109
        7009
        7010
      Multi_point (42)
      Pos_neg_data: 354
        8378
        8386
        8389
        8550
  Reference: WBPaper00000031
    WBPaper00000608
    WBPaper00001256
    WBPaper00001296
    WBPaper00001345
    WBPaper00001473
    WBPaper00001500
    WBPaper00001584
    WBPaper00001704
    WBPaper00001750
    WBPaper00001759
    WBPaper00001760
    WBPaper00001780
    WBPaper00001847
    WBPaper00001920
    WBPaper00002272
    WBPaper00002297
    WBPaper00002341
    WBPaper00002487
    WBPaper00002590
    WBPaper00003187
    WBPaper00003191
    WBPaper00003350
    WBPaper00003509
    WBPaper00003607
    WBPaper00003619
    WBPaper00003678
    WBPaper00003781
    WBPaper00003937
    WBPaper00004117
    WBPaper00004217
    WBPaper00004257
    WBPaper00004295
    WBPaper00004409
    WBPaper00004458
    WBPaper00004839
    WBPaper00004883
    WBPaper00004889
    WBPaper00005163
    WBPaper00005218
    WBPaper00005243
    WBPaper00005274
    WBPaper00005423
    WBPaper00005511
    WBPaper00005543
    WBPaper00005798
    WBPaper00006029
    WBPaper00006071
    WBPaper00006103
    WBPaper00006106
    WBPaper00006180
    WBPaper00006286
    WBPaper00006382
    WBPaper00006427
    WBPaper00006431
    WBPaper00011225
    WBPaper00011480
    WBPaper00011509
    WBPaper00014154
    WBPaper00014215
    WBPaper00014220
    WBPaper00014234
    WBPaper00014313
    WBPaper00014562
    WBPaper00014863
    WBPaper00014956
    WBPaper00015029
    WBPaper00015052
    WBPaper00015081
    WBPaper00015141
    WBPaper00015403
    WBPaper00015404
    WBPaper00015529
    WBPaper00015530
    WBPaper00015616
    WBPaper00015696
    WBPaper00015718
    WBPaper00016473
    WBPaper00016551
    WBPaper00016702
    WBPaper00016723
    WBPaper00016756
    WBPaper00016817
    WBPaper00016962
    WBPaper00016974
    WBPaper00017074
    WBPaper00017104
    WBPaper00017302
    WBPaper00017444
    WBPaper00017467
    WBPaper00017491
    WBPaper00017705
    WBPaper00017967
    WBPaper00018009
    WBPaper00018015
    WBPaper00018033
    WBPaper00018118
    WBPaper00018298
    WBPaper00018337
    WBPaper00018797
    WBPaper00019199
    WBPaper00019233
    WBPaper00019329
    WBPaper00019333
    WBPaper00019357
    WBPaper00019362
    WBPaper00019671
    WBPaper00020843
    WBPaper00020971
    WBPaper00021100
    WBPaper00021115
    WBPaper00021852
    WBPaper00022263
    WBPaper00022337
    WBPaper00022476
    WBPaper00022852
    WBPaper00022974
    WBPaper00022996
    WBPaper00022998
    WBPaper00023027
    WBPaper00023090
    WBPaper00023193
    WBPaper00023227
    WBPaper00023250
    WBPaper00023444
    WBPaper00023508
    WBPaper00023969
    WBPaper00023983
    WBPaper00024090
    WBPaper00024160
    WBPaper00024317
    WBPaper00024422
    WBPaper00024523
    WBPaper00024600
    WBPaper00024970
    WBPaper00025052
    WBPaper00025096
    WBPaper00025404
    WBPaper00025600
    WBPaper00025722
    WBPaper00025755
    WBPaper00025822
    WBPaper00026729
    WBPaper00026870
    WBPaper00027250
    WBPaper00027299
    WBPaper00027305
    WBPaper00027309
    WBPaper00027352
    WBPaper00028082
    WBPaper00028494
    WBPaper00028525
    WBPaper00030393
    WBPaper00030788
    WBPaper00030977
    WBPaper00031872
    WBPaper00032201
    WBPaper00032331
    WBPaper00032358
    WBPaper00032691
    WBPaper00032731
    WBPaper00035198
    WBPaper00035944
    WBPaper00036072
    WBPaper00036766
    WBPaper00037167
    WBPaper00037218
    WBPaper00038410
    WBPaper00038491
    WBPaper00038509
    WBPaper00039246
    WBPaper00040284
    WBPaper00040304
    WBPaper00041877
    WBPaper00042154
    WBPaper00043348
    WBPaper00043447
    WBPaper00043839
    WBPaper00043853
    WBPaper00044407
    WBPaper00045634
    WBPaper00046856
    WBPaper00047916
    WBPaper00049579
    WBPaper00050339
    WBPaper00055090
    WBPaper00055155
    WBPaper00055157
    WBPaper00055158
    WBPaper00056066
    WBPaper00056338
    WBPaper00057074
    WBPaper00057202
    WBPaper00059169
    WBPaper00059268
    WBPaper00059377
    WBPaper00059551
    WBPaper00059613
    WBPaper00059740
    WBPaper00060104
    WBPaper00060270
    WBPaper00060809
    WBPaper00060815
    WBPaper00061272
    WBPaper00061589
    WBPaper00064432
    WBPaper00064466
    WBPaper00064789
    WBPaper00064809
    WBPaper00065118
    WBPaper00065331
    WBPaper00065340
    WBPaper00065640
    WBPaper00065712
    WBPaper00065757
    WBPaper00065929
  Method: Gene