WormBase Tree Display for Gene: WBGene00006767
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| WBGene00006767 | SMap | S_parent | Sequence | ZK897 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-31 | Person_evidence | WBPerson261 | |||||
| Sequence_name | ZK897.1 | ||||||||
| Molecular_name (57) | |||||||||
| Other_name | egl-22 | ||||||||
| CELE_ZK897.1 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | unc-31 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143006 | ||||||||
| Allele (276) | |||||||||
| Possibly_affected_by | WBVar02158839 | ||||||||
| Legacy_information | e169ts : very slow and sluggish moves better in absence of bacteria; insensitive to prodding; constitutive pharyngeal pumping. ES2 ME1 NA > 10 (n1304 (resembles e169) e69 e86 u280 etc.). | ||||||||
| See also ad512, e69, e86, e379, e714, e717, e1512, e1919, e2126, e2183, e2202, e2203, e2204, e2478, e2479, n422, n577, n1304 | |||||||||
| [C.elegansII] e169ts : very slow and sluggish, moves better in absence of bacteria; insensitive to prodding; constitutive pharyngeal pumping; weak Daf-c; poor dauer recovery; Egl. More active when starved. No obvious changes in neuroanatomy.ES2 ME1 OA>10: e69amb, e86, e375amb, n1304(all resemble e169), n422ts (pka egl-22, variable transient bloating at 25C, stimulated by serotonin and by imipramine; uncoordinated limp paralysed phenotype. ES3 (adult, larvae)), e928 (strongest allele, deletion null; resembles e169), n577ts, st198, u378, z1, etc. Cloned: encodes predicted 138 kD novel protein; antibody stains axons of most neurons. See also rsn-13. [Avery et al. 1993; CB; DA; MT] | |||||||||
| Strain (83) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (41) | |||||||||
| Ortholog (49) | |||||||||
| Structured_description | Concise_description | unc-31 encodes a pleckstrin homology (PH) domain-containing protein that is the C. elegans ortholog of human CADPS/CAPS (calcium-dependent activator protein for secretion OMIM:604667); UNC-31 functions in post-docking calcium-regulated dense-core vesicle fusion that is required for egg laying, locomotion, pharyngeal pumping, and recovery from the dauer larval stage; in addition, UNC-31 functions in the insulin receptor signaling pathway that regulates adult life span where it may control Ca[2+]-regulated secretion of an insulin-like ligand; UNC-31 is not required for synaptic vesicle exocytosis; unc-31::gfp transcriptional reporters are expressed in most, if not all, neurons, vulval muscles, vulval cells, the spermatheca, and secretory cells such as the uterine UV1 cells; UNC-31::GFP translational fusions localize to neuronal cell bodies, axonal projections and to sites of synaptic contact, consistent with other dense-core vesicle proteins. | Paper_evidence | WBPaper00000635 | |||||
| WBPaper00001733 | |||||||||
| WBPaper00003572 | |||||||||
| WBPaper00004405 | |||||||||
| WBPaper00005528 | |||||||||
| WBPaper00030754 | |||||||||
| Curator_confirmed | WBPerson48 | ||||||||
| WBPerson1843 | |||||||||
| Date_last_updated | 07 Aug 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable calcium ion binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including cellular response to carbon dioxide; regulation of multicellular organismal process; and signal release. Located in several cellular components, including axon; dense core granule; and neuronal cell body. Expressed in several structures, including egg-laying apparatus; excretory gland cell; nervous system; postcloacal sensillum; and rectal gland cell. Is an ortholog of human CADPS2 (calcium dependent secretion activator 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS (19) | ||||||||
| Corresponding_CDS_history | ZK897.1:wp47 | ||||||||
| ZK897.1:wp119 | |||||||||
| ZK897.1:wp165 | |||||||||
| ZK897.1a:wp212 | |||||||||
| ZK897.1b:wp212 | |||||||||
| Corresponding_transcript (19) | |||||||||
| Other_sequence (49) | |||||||||
| Associated_feature (29) | |||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00000441 | ||||||||
| WBCnstr00006451 | |||||||||
| WBCnstr00006541 | |||||||||
| WBCnstr00006542 | |||||||||
| WBCnstr00006711 | |||||||||
| WBCnstr00007093 | |||||||||
| WBCnstr00012240 | |||||||||
| WBCnstr00012241 | |||||||||
| WBCnstr00034162 | |||||||||
| Construct_product (11) | |||||||||
| Antibody | WBAntibody00001029 | ||||||||
| WBAntibody00001259 | |||||||||
| Microarray_results (30) | |||||||||
| Expression_cluster (149) | |||||||||
| Interaction | WBInteraction000000162 | ||||||||
| WBInteraction000000498 | |||||||||
| WBInteraction000000500 | |||||||||
| WBInteraction000000866 | |||||||||
| WBInteraction000000869 | |||||||||
| WBInteraction000000935 | |||||||||
| WBInteraction000001140 | |||||||||
| WBInteraction000001143 | |||||||||
| WBInteraction000001158 | |||||||||
| WBInteraction000001211 | |||||||||
| WBInteraction000001224 | |||||||||
| WBInteraction000001226 | |||||||||
| WBInteraction000001568 | |||||||||
| WBInteraction000002284 | |||||||||
| WBInteraction000002379 | |||||||||
| WBInteraction000004793 | |||||||||
| WBInteraction000004794 | |||||||||
| WBInteraction000004795 | |||||||||
| WBInteraction000004866 | |||||||||
| WBInteraction000004933 | |||||||||
| WBInteraction000005408 | |||||||||
| WBInteraction000009629 | |||||||||
| WBInteraction000028531 | |||||||||
| WBInteraction000028854 | |||||||||
| WBInteraction000028968 | |||||||||
| WBInteraction000028969 | |||||||||
| WBInteraction000030280 | |||||||||
| WBInteraction000030292 | |||||||||
| WBInteraction000030885 | |||||||||
| WBInteraction000031788 | |||||||||
| WBInteraction000031854 | |||||||||
| WBInteraction000052071 | |||||||||
| WBInteraction000052107 | |||||||||
| WBInteraction000052182 | |||||||||
| WBInteraction000052339 | |||||||||
| WBInteraction000126299 | |||||||||
| WBInteraction000126556 | |||||||||
| WBInteraction000133172 | |||||||||
| WBInteraction000165150 | |||||||||
| WBInteraction000165165 | |||||||||
| WBInteraction000165629 | |||||||||
| WBInteraction000165654 | |||||||||
| WBInteraction000165770 | |||||||||
| WBInteraction000166351 | |||||||||
| WBInteraction000166503 | |||||||||
| WBInteraction000169180 | |||||||||
| WBInteraction000177213 | |||||||||
| WBInteraction000196875 | |||||||||
| WBInteraction000209199 | |||||||||
| WBInteraction000221466 | |||||||||
| WBInteraction000225107 | |||||||||
| WBInteraction000227270 | |||||||||
| WBInteraction000272823 | |||||||||
| WBInteraction000326959 | |||||||||
| WBInteraction000351281 | |||||||||
| WBInteraction000417933 | |||||||||
| WBInteraction000464729 | |||||||||
| WBInteraction000466676 | |||||||||
| WBInteraction000469450 | |||||||||
| WBInteraction000500514 | |||||||||
| WBInteraction000504821 | |||||||||
| WBInteraction000505153 | |||||||||
| WBInteraction000525338 | |||||||||
| WBInteraction000534853 | |||||||||
| WBInteraction000537564 | |||||||||
| WBInteraction000583822 | |||||||||
| WBInteraction000584160 | |||||||||
| WBProcess | WBbiopr:00000039 | ||||||||
| Map_info | Map | IV | Position | 6.31807 | Error | 0.015395 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf21 | |||||||
| sDf22 | |||||||||
| sDf24 | |||||||||
| Positive_clone | C14G10 | ||||||||
| ZK897 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point (12) | ||||||||
| Multi_point (75) | |||||||||
| Pos_neg_data (13) | |||||||||
| Reference (247) | |||||||||
| Method | Gene |
