WormBase Tree Display for Gene: WBGene00006769
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WBGene00006769 | SMap | S_parent | Sequence | Y37E11C | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143034 | ||||||
Allele (224) | |||||||
Possibly_affected_by | WBVar02156987 | ||||||
Legacy_information | e204 : very slow almost paralysed tends to curl dumpyish; weak FITC uptake; amphid phasmid PDE axons abnormal; abnormal neuronal microtubules. ES3 ME0. NA5 (e572 e735). | ||||||
See also e572, e1193, e1261, e1358 | |||||||
[C.elegansII] e204 : very slow, almost paralysed; tends to curl; dumpyish; weak FITC uptake; amphid, phasmid, PDE, PVP axons abnormal; multiple defects in axonogenesis; abnormally abundant neuronal microtubules. ES3 ME0. OA>10: e572, e735, e1358, m7,mn260::Tc4, rh1030::Tc4, etc. Cloned: 2.8, 3.3, 3.8 kb transcripts (different 5' ends) encoding predicted 523 aa, 679 aa, 854 aa proteins with similarity to collapsin??? Antibody stains all neuron processes in larvae and adults. [Hedgecock et al. 1985; Li et al. 1992; EH; SP] | |||||||
[Li W] mn260 is Tc4 insertion in exon VII of longest (3.8kb) unc-33 transcript. rh1030 same insertion site, modified Tc4 element. | |||||||
Strain (29) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (28) | |||||||
Contained_in_operon | CEOP4092 | ||||||
Ortholog (37) | |||||||
Paralog | WBGene00000963 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00000964 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | unc-33 encodes a conserved member of the CRMP/TOAD/Ulip/DRP family of proteins that includes mammalian CRMP-2 (Collapsin response mediator protein-2), which is essential for axon guidance and axonogenesis; in C. elegans, unc-33 activity is required for several biological processes including outgrowth and guidance of sensory, motor, and interneurons, sex myoblast migration, normal body movement and morphology, egg laying, and defecation; by homology to CRMP-2, UNC-33 is predicted to bind tubulin heterodimers and promote microtubule assembly, thereby regulating the extension and branching of cellular projections during neuronal polarization; UNC-33 is reportedly expressed exclusively in axonal processes from after early embryogenesis through larval and adult stages. | Paper_evidence | WBPaper00001622 | |||
WBPaper00002665 | |||||||
WBPaper00004362 | |||||||
WBPaper00010044 | |||||||
WBPaper00025204 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 06 Jun 2005 00:00:00 | ||||||
Automated_description | Enables filamin binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including axon guidance; establishment or maintenance of cytoskeleton polarity; and regulation of locomotion. Located in neuron projection. Expressed in amphid socket cell; neuroblasts; neurons; pharyngeal cell; and somatic nervous system. Is an ortholog of human DPYSL2 (dihydropyrimidinase like 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | Y37E11C.1a | |||||
Y37E11C.1b | |||||||
Y37E11C.1c | |||||||
Corresponding_CDS_history | Y37E11C.1:wp82 | ||||||
Y37E11C.1a:wp145 | |||||||
Y37E11C.1b:wp145 | |||||||
Y37E11C.1c:wp145 | |||||||
Y37E11C.1c:wp273 | |||||||
Corresponding_transcript | Y37E11C.1a.1 | ||||||
Y37E11C.1b.1 | |||||||
Y37E11C.1c.1 | |||||||
Other_sequence (38) | |||||||
Associated_feature (12) | |||||||
Experimental_info | RNAi_result | WBRNAi00103588 | Inferred_automatically | RNAi_primary | |||
WBRNAi00020239 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086120 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00055925 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00055924 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089774 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090316 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00030274 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090157 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089998 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00001590 | ||||||
WBCnstr00001591 | |||||||
WBCnstr00006869 | |||||||
Construct_product (15) | |||||||
Antibody | WBAntibody00000953 | ||||||
WBAntibody00000954 | |||||||
WBAntibody00001546 | |||||||
WBAntibody00001788 | |||||||
WBAntibody00001922 | |||||||
WBAntibody00002299 | |||||||
Microarray_results (28) | |||||||
Expression_cluster (148) | |||||||
Interaction (69) | |||||||
WBProcess | WBbiopr:00000010 | ||||||
Map_info | Map | IV | Position | -3.30458 | Error | 0.013709 | |
Well_ordered | |||||||
Positive | Inside_rearr | mDp4 | |||||
Positive_clone | EH#143 | ||||||
Y37E11 | |||||||
Y37E11C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 99 | |||||
484 | |||||||
824 | |||||||
1643 | |||||||
3276 | |||||||
Multi_point (15) | |||||||
Pos_neg_data | 9110 | ||||||
Reference (123) | |||||||
Remark | extracted from Li et al. (1992) | ||||||
sequence match was given and M57.b and.c but theses overlap with Y37E11C.c which has not been annotated yet. sdm 11/00. will probably acquire name Y37E11C.1 | |||||||
Method | Gene |