WormBase Tree Display for Gene: WBGene00006775

WBGene00006775 SMap: S_parent: Sequence: F56A12
  Identity: Version: 2
    Name: CGC_name: unc-39 Person_evidence: WBPerson261
      Sequence_name: F56A12.1
      Molecular_name: F56A12.1
        F56A12.1.1
        CE37921
      Other_name: mig-3
        ceh-35 Paper_evidence: WBPaper00024327
        CELE_F56A12.1 Accession_evidence: NDB BX284605
      Public_name: unc-39
    DB_info: Database: AceView gene 5O855
        WormQTL gene WBGene00006775
        WormFlux gene WBGene00006775
        OMIM disease 610896
            160900
          gene 600963
        NDB locus_tag CELE_F56A12.1
        Panther gene CAEEL|WormBase=WBGene00006775|UniProtKB=O17894
          family PTHR10390
        NCBI gene 191623
        RefSeq protein NM_074162.3
        SwissProt UniProtAcc O17894
        UniProt_GCRP UniProtAcc O17894
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 09 Nov 2004 14:53:34 WBPerson2970 Event: Acquires_merge: WBGene00000456
      Acquires_merge: WBGene00000456
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143068
    Allele (43)
    Legacy_information: e257 : fairly severe kinker can move forward and backward fairly active slightly dumpy. ES2 ME1. NA1.
      ct73 : abnormal migration of CAN cells.
      [C.elegansII] e257 : fairly severe kinker, can move forward and backward; fairly active, slightly dumpy; often withered tail as a result of80% CAN migration defect; other migrations also variably defective. 15% of hermaphrodites have third gonad arm arising from additional somatic gonad founder, "Z5". e257/Df more severe phenotypes. ES2 ME1. OA2: ct73 (pka mig-3,abnormal migration of CAN cells), rh72. [Hedgecock et al. 1987; Manser and Wood 1990; CF; NJ]
      [Ruvkun,01/98]. so class homeobox gene.
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (24)
    Ortholog (45)
    Paralog: WBGene00000453 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000454 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000455 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00008195 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: unc-39 encodes a homeodomain transcription factor that belongs to the Six4/5 family of homeodomain proteins that includes human Six5; UNC-39 is required for axonal pathfinding in anterior-derived neurons and for specification of most mesodermal cell types and may regulate a developmental decision between migration and differentiation; UNC-39 is expressed in the embryo in anterior neurons, posteriorly derived mesoderm (somatic gonad, M mesoblast, and possibly the coelomocytes and muIntR), the CAN neurons, and body wall muscle. Paper_evidence: WBPaper00024327
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Nov 2005 00:00:00
      Automated_description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; generation of neurons; and regulation of locomotion. Located in nucleus. Expressed in several structures, including AIA; IL2 neuron; RID; coelomocyte; and neuroblasts. Used to study branchiootorenal syndrome and myotonic dystrophy type 1. Human ortholog(s) of this gene implicated in branchiootorenal syndrome 2. Is an ortholog of human SIX4 (SIX homeobox 4) and SIX5 (SIX homeobox 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:11722 Homo sapiens Paper_evidence: WBPaper00024327
          Accession_evidence: OMIM 160900
          Curator_confirmed: WBPerson324
          Date_last_updated: 24 Oct 2013 00:00:00
      DOID:14702 Homo sapiens Paper_evidence: WBPaper00024327
          Accession_evidence: OMIM 610896
          Curator_confirmed: WBPerson324
          Date_last_updated: 24 Oct 2013 00:00:00
    Potential_model: DOID:0111424 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10891)
    Disease_relevance: Mutations in the human Six5 protein have been implicated in Myotonic dystrophy 1 (DM1), a highly variable disease characterized by progressive muscle wasting, eye cataracts, cardiac abnormalities, and insulin resistance; in C. elegans, mutants in unc-29 (e257), orthologous to human Six5, show uncoordinated movement, mesodermal defects, and neuronal developmental and pathfinding defects; these studies indicate that unc-29/Six5 may be involved in development of mesoderm and differentiation and migration of neurons; the variable expressivity and penetrance of unc-39 defects are reminiscent of the pleiotropy seen in DM1 patients; some of the unc-29 mutant defects (coelomocyte specification) could be rescued by a transgene containing Six domain and homeodomain coding region from human Six5, showing a functional conservation between unc-29 and Six5; these studies indicate that unc-29 serves as a model to study how Six5 plays a role in conditions leading to myotonic dystrophy. Homo sapiens Paper_evidence: WBPaper00024327
          Accession_evidence: OMIM 600963
              160900
              610896
          Curator_confirmed: WBPerson324
          Date_last_updated: 01 May 2014 00:00:00
  Models_disease_asserted: WBDOannot00000238
    WBDOannot00000299
  Molecular_info: Corresponding_CDS: F56A12.1
    Corresponding_CDS_history: F56A12.1:wp137
    Corresponding_transcript: F56A12.1.1
    Other_sequence: Acan_isotig06578
      Dviv_isotig15575
      Dviv_isotig15576
      Acan_isotig06577
      Oden_isotig18067
      Tcir_isotig25512
      Oden_isotig25907
      JI463737.1
      Oden_isotig18066
      JI211494.1
    Associated_feature: WBsf647528
      WBsf662081
      WBsf662082
      WBsf662083
      WBsf978863
      WBsf1001995
      WBsf1020832
      WBsf232919
      WBsf232920
    Gene_product_binds (218)
    Transcription_factor: WBTranscriptionFactor000219
  Experimental_info: RNAi_result: WBRNAi00101784 Inferred_automatically: RNAi_primary
      WBRNAi00032912 Inferred_automatically: RNAi_primary
      WBRNAi00089718 Inferred_automatically: RNAi_primary
      WBRNAi00090158 Inferred_automatically: RNAi_primary
      WBRNAi00090317 Inferred_automatically: RNAi_primary
      WBRNAi00061182 Inferred_automatically: RNAi_primary
      WBRNAi00015762 Inferred_automatically: RNAi_primary
      WBRNAi00048581 Inferred_automatically: RNAi_primary
      WBRNAi00114716 Inferred_automatically: RNAi_primary
      WBRNAi00089999 Inferred_automatically: RNAi_primary
    Expr_pattern (12)
    Drives_construct: WBCnstr00004349
      WBCnstr00011130
      WBCnstr00012730
      WBCnstr00015880
      WBCnstr00016522
      WBCnstr00034159
    Construct_product: WBCnstr00011130
      WBCnstr00015880
      WBCnstr00016701
      WBCnstr00034159
    Regulate_expr_cluster: WBPaper00050496:unc-39(hp701)_regulated
    Microarray_results (20)
    Expression_cluster (153)
    Interaction (134)
  Map_info: Map: V Position: 6.28117 Error: 0.001023
    Positive: Positive_clone: F56A12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 132
        839
        1725
      Multi_point (14)
      Pos_neg_data: 297
        2131
        3132
        4308
  Reference (35)
  Method: Gene