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WormBase Tree Display for Gene: WBGene00006775

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Name Class

WBGene00006775SMapS_parentSequenceF56A12
IdentityVersion2
NameCGC_nameunc-39Person_evidenceWBPerson261
Sequence_nameF56A12.1
Molecular_nameF56A12.1
F56A12.1.1
CE37921
Other_namemig-3
ceh-35Paper_evidenceWBPaper00024327
CELE_F56A12.1Accession_evidenceNDBBX284605
Public_nameunc-39
DB_infoDatabaseAceViewgene5O855
WormQTLgeneWBGene00006775
WormFluxgeneWBGene00006775
OMIMdisease610896
160900
gene600963
NDBlocus_tagCELE_F56A12.1
PanthergeneCAEEL|WormBase=WBGene00006775|UniProtKB=O17894
familyPTHR10390
NCBIgene191623
RefSeqproteinNM_074162.3
SwissProtUniProtAccO17894
UniProt_GCRPUniProtAccO17894
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
209 Nov 2004 14:53:34WBPerson2970EventAcquires_mergeWBGene00000456
Acquires_mergeWBGene00000456
StatusLive
Gene_info (11)
Disease_infoExperimental_modelDOID:11722Homo sapiensPaper_evidenceWBPaper00024327
Accession_evidenceOMIM160900
Curator_confirmedWBPerson324
Date_last_updated24 Oct 2013 00:00:00
DOID:14702Homo sapiensPaper_evidenceWBPaper00024327
Accession_evidenceOMIM610896
Curator_confirmedWBPerson324
Date_last_updated24 Oct 2013 00:00:00
Potential_modelDOID:0111424Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10891)
Disease_relevanceMutations in the human Six5 protein have been implicated in Myotonic dystrophy 1 (DM1), a highly variable disease characterized by progressive muscle wasting, eye cataracts, cardiac abnormalities, and insulin resistance; in C. elegans, mutants in unc-29 (e257), orthologous to human Six5, show uncoordinated movement, mesodermal defects, and neuronal developmental and pathfinding defects; these studies indicate that unc-29/Six5 may be involved in development of mesoderm and differentiation and migration of neurons; the variable expressivity and penetrance of unc-39 defects are reminiscent of the pleiotropy seen in DM1 patients; some of the unc-29 mutant defects (coelomocyte specification) could be rescued by a transgene containing Six domain and homeodomain coding region from human Six5, showing a functional conservation between unc-29 and Six5; these studies indicate that unc-29 serves as a model to study how Six5 plays a role in conditions leading to myotonic dystrophy.Homo sapiensPaper_evidenceWBPaper00024327
Accession_evidenceOMIM600963
160900
610896
Curator_confirmedWBPerson324
Date_last_updated01 May 2014 00:00:00
Models_disease_assertedWBDOannot00000238
WBDOannot00000299
Molecular_infoCorresponding_CDSF56A12.1
Corresponding_CDS_historyF56A12.1:wp137
Corresponding_transcriptF56A12.1.1
Other_sequenceAcan_isotig06578
Dviv_isotig15575
Dviv_isotig15576
Acan_isotig06577
Oden_isotig18067
Tcir_isotig25512
Oden_isotig25907
JI463737.1
Oden_isotig18066
JI211494.1
Associated_featureWBsf647528
WBsf662081
WBsf662082
WBsf662083
WBsf978863
WBsf1001995
WBsf1020832
WBsf232919
WBsf232920
Gene_product_bindsWBsf977575
WBsf977579
WBsf977580
WBsf977582
WBsf977583
WBsf977584
WBsf977588
WBsf977589
WBsf977590
WBsf977591
WBsf977593
WBsf977594
WBsf977596
WBsf977603
WBsf977606
WBsf977607
WBsf977608
WBsf977611
WBsf977613
WBsf977614
WBsf977615
WBsf977620
WBsf977621
WBsf977624
WBsf977626
WBsf977628
WBsf977629
WBsf977630
WBsf977631
WBsf977635
WBsf977638
WBsf977643
WBsf977644
WBsf977647
WBsf977649
WBsf977652
WBsf977654
WBsf977655
WBsf977659
WBsf977663
WBsf977664
WBsf977665
WBsf977666
WBsf977668
WBsf977671
WBsf977673
WBsf977674
WBsf977675
WBsf977677
WBsf977679
WBsf977680
WBsf977682
WBsf977684
WBsf977685
WBsf977686
WBsf977687
WBsf977688
WBsf977689
WBsf977692
WBsf977693
WBsf977694
WBsf977696
WBsf977699
WBsf977700
WBsf977701
WBsf977703
WBsf977706
WBsf977708
WBsf977710
WBsf977713
WBsf977714
WBsf977715
WBsf977718
WBsf977720
WBsf977722
WBsf977723
WBsf977724
WBsf977725
WBsf977728
WBsf977729
WBsf977731
WBsf977733
WBsf977734
WBsf977736
WBsf977738
WBsf977740
WBsf977741
WBsf977744
WBsf977747
WBsf977749
WBsf977750
WBsf977753
WBsf977754
WBsf977755
WBsf977757
WBsf977761
WBsf977762
WBsf977766
WBsf977768
WBsf977770
WBsf977771
WBsf977772
WBsf977775
WBsf977776
WBsf977778
WBsf977779
WBsf977780
WBsf977781
WBsf977783
WBsf977785
WBsf977786
WBsf977789
WBsf977790
WBsf977791
WBsf977797
WBsf977800
WBsf977802
WBsf977807
WBsf977808
WBsf977810
WBsf977811
WBsf977812
WBsf977813
WBsf977817
WBsf977818
WBsf977821
WBsf977822
WBsf977825
WBsf977829
WBsf977830
WBsf977831
WBsf977832
WBsf977833
WBsf977834
WBsf977838
WBsf977840
WBsf977841
WBsf977843
WBsf977845
WBsf977846
WBsf977847
WBsf977849
WBsf977851
WBsf977852
WBsf977853
WBsf977854
WBsf977855
WBsf977856
WBsf977858
WBsf977860
WBsf977861
WBsf977864
WBsf977868
WBsf977870
WBsf977871
WBsf977872
WBsf977873
WBsf977874
WBsf977875
WBsf977876
WBsf977878
WBsf977879
WBsf977880
WBsf977881
WBsf977883
WBsf977884
WBsf977886
WBsf977888
WBsf977889
WBsf977890
WBsf977891
WBsf977893
WBsf977896
WBsf977898
WBsf977899
WBsf977900
WBsf977902
WBsf977903
WBsf977904
WBsf977905
WBsf977906
WBsf977907
WBsf977908
WBsf977910
WBsf977911
WBsf977912
WBsf977913
WBsf977914
WBsf977915
WBsf977916
WBsf977917
WBsf977918
WBsf977919
WBsf977920
WBsf977921
WBsf977922
WBsf977923
WBsf977924
WBsf977926
WBsf977927
WBsf977928
WBsf977929
WBsf977930
WBsf977931
WBsf977933
WBsf977934
WBsf977935
WBsf977936
WBsf977938
WBsf977939
WBsf977940
WBsf977941
WBsf977942
WBsf977943
WBsf977945
WBsf977946
WBsf977948
WBsf977949
Transcription_factorWBTranscriptionFactor000219
Experimental_infoRNAi_resultWBRNAi00101784Inferred_automaticallyRNAi_primary
WBRNAi00032912Inferred_automaticallyRNAi_primary
WBRNAi00089718Inferred_automaticallyRNAi_primary
WBRNAi00090158Inferred_automaticallyRNAi_primary
WBRNAi00090317Inferred_automaticallyRNAi_primary
WBRNAi00061182Inferred_automaticallyRNAi_primary
WBRNAi00015762Inferred_automaticallyRNAi_primary
WBRNAi00048581Inferred_automaticallyRNAi_primary
WBRNAi00114716Inferred_automaticallyRNAi_primary
WBRNAi00089999Inferred_automaticallyRNAi_primary
Expr_pattern (12)
Drives_constructWBCnstr00004349
WBCnstr00011130
WBCnstr00012730
WBCnstr00015880
WBCnstr00016522
WBCnstr00034159
Construct_productWBCnstr00011130
WBCnstr00015880
WBCnstr00016701
WBCnstr00034159
Regulate_expr_clusterWBPaper00050496:unc-39(hp701)_regulated
Microarray_results (20)
Expression_cluster (153)
Interaction (134)
Map_infoMapVPosition6.28117Error0.001023
PositivePositive_cloneF56A12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point132
839
1725
Multi_point (14)
Pos_neg_data297
2131
3132
4308
Reference (35)
MethodGene