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WormBase Tree Display for Gene: WBGene00006775

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Name Class

WBGene00006775SMapS_parentSequenceF56A12
IdentityVersion2
NameCGC_nameunc-39Person_evidenceWBPerson261
Sequence_nameF56A12.1
Molecular_nameF56A12.1
F56A12.1.1
CE37921
Other_namemig-3
ceh-35Paper_evidenceWBPaper00024327
CELE_F56A12.1Accession_evidenceNDBBX284605
Public_nameunc-39
DB_infoDatabaseAceViewgene5O855
WormQTLgeneWBGene00006775
WormFluxgeneWBGene00006775
OMIMdisease610896
160900
gene600963
NDBlocus_tagCELE_F56A12.1
PanthergeneCAEEL|WormBase=WBGene00006775|UniProtKB=O17894
familyPTHR10390
NCBIgene191623
RefSeqproteinNM_074162.3
SwissProtUniProtAccO17894
UniProt_GCRPUniProtAccO17894
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:42WBPerson1971EventImportedInitial conversion from geneace
209 Nov 2004 14:53:34WBPerson2970EventAcquires_mergeWBGene00000456
Acquires_mergeWBGene00000456
StatusLive
Gene_info (11)
Disease_infoExperimental_modelDOID:11722Homo sapiensPaper_evidenceWBPaper00024327
Accession_evidenceOMIM160900
Curator_confirmedWBPerson324
Date_last_updated24 Oct 2013 00:00:00
DOID:14702Homo sapiensPaper_evidenceWBPaper00024327
Accession_evidenceOMIM610896
Curator_confirmedWBPerson324
Date_last_updated24 Oct 2013 00:00:00
Potential_modelDOID:0111424Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:10891)
Disease_relevanceMutations in the human Six5 protein have been implicated in Myotonic dystrophy 1 (DM1), a highly variable disease characterized by progressive muscle wasting, eye cataracts, cardiac abnormalities, and insulin resistance; in C. elegans, mutants in unc-29 (e257), orthologous to human Six5, show uncoordinated movement, mesodermal defects, and neuronal developmental and pathfinding defects; these studies indicate that unc-29/Six5 may be involved in development of mesoderm and differentiation and migration of neurons; the variable expressivity and penetrance of unc-39 defects are reminiscent of the pleiotropy seen in DM1 patients; some of the unc-29 mutant defects (coelomocyte specification) could be rescued by a transgene containing Six domain and homeodomain coding region from human Six5, showing a functional conservation between unc-29 and Six5; these studies indicate that unc-29 serves as a model to study how Six5 plays a role in conditions leading to myotonic dystrophy.Homo sapiensPaper_evidenceWBPaper00024327
Accession_evidenceOMIM600963
160900
610896
Curator_confirmedWBPerson324
Date_last_updated01 May 2014 00:00:00
Models_disease_assertedWBDOannot00000238
WBDOannot00000299
Molecular_infoCorresponding_CDSF56A12.1
Corresponding_CDS_historyF56A12.1:wp137
Corresponding_transcriptF56A12.1.1
Other_sequenceAcan_isotig06578
Dviv_isotig15575
Dviv_isotig15576
Acan_isotig06577
Oden_isotig18067
Tcir_isotig25512
Oden_isotig25907
JI463737.1
Oden_isotig18066
JI211494.1
Associated_featureWBsf647528
WBsf662081
WBsf662082
WBsf662083
WBsf978863
WBsf1001995
WBsf1020832
WBsf232919
WBsf232920
Gene_product_binds (218)
Transcription_factorWBTranscriptionFactor000219
Experimental_infoRNAi_resultWBRNAi00101784Inferred_automaticallyRNAi_primary
WBRNAi00032912Inferred_automaticallyRNAi_primary
WBRNAi00089718Inferred_automaticallyRNAi_primary
WBRNAi00090158Inferred_automaticallyRNAi_primary
WBRNAi00090317Inferred_automaticallyRNAi_primary
WBRNAi00061182Inferred_automaticallyRNAi_primary
WBRNAi00015762Inferred_automaticallyRNAi_primary
WBRNAi00048581Inferred_automaticallyRNAi_primary
WBRNAi00114716Inferred_automaticallyRNAi_primary
WBRNAi00089999Inferred_automaticallyRNAi_primary
Expr_pattern (12)
Drives_constructWBCnstr00004349
WBCnstr00011130
WBCnstr00012730
WBCnstr00015880
WBCnstr00016522
WBCnstr00034159
Construct_productWBCnstr00011130
WBCnstr00015880
WBCnstr00016701
WBCnstr00034159
Regulate_expr_clusterWBPaper00050496:unc-39(hp701)_regulated
Microarray_results (20)
Expression_cluster (153)
InteractionWBInteraction000030501
WBInteraction000031897
WBInteraction000135498
WBInteraction000135499
WBInteraction000135623
WBInteraction000147246
WBInteraction000222057
WBInteraction000227065
WBInteraction000235937
WBInteraction000247154
WBInteraction000250902
WBInteraction000253064
WBInteraction000253991
WBInteraction000257961
WBInteraction000259456
WBInteraction000262795
WBInteraction000263365
WBInteraction000269507
WBInteraction000272294
WBInteraction000273384
WBInteraction000281108
WBInteraction000285561
WBInteraction000289180
WBInteraction000290727
WBInteraction000291413
WBInteraction000291551
WBInteraction000299147
WBInteraction000300751
WBInteraction000305196
WBInteraction000307900
WBInteraction000308535
WBInteraction000316088
WBInteraction000317703
WBInteraction000318220
WBInteraction000320519
WBInteraction000320593
WBInteraction000321701
WBInteraction000324976
WBInteraction000327396
WBInteraction000348454
WBInteraction000353063
WBInteraction000353607
WBInteraction000354870
WBInteraction000357809
WBInteraction000358033
WBInteraction000358317
WBInteraction000360118
WBInteraction000360308
WBInteraction000361298
WBInteraction000364600
WBInteraction000365709
WBInteraction000366485
WBInteraction000367450
WBInteraction000368409
WBInteraction000368771
WBInteraction000369686
WBInteraction000371167
WBInteraction000371184
WBInteraction000373305
WBInteraction000376698
WBInteraction000379865
WBInteraction000380023
WBInteraction000381238
WBInteraction000382476
WBInteraction000384137
WBInteraction000385208
WBInteraction000386787
WBInteraction000387111
WBInteraction000390297
WBInteraction000390885
WBInteraction000399228
WBInteraction000402756
WBInteraction000404261
WBInteraction000409422
WBInteraction000409531
WBInteraction000410647
WBInteraction000412873
WBInteraction000414457
WBInteraction000415813
WBInteraction000416570
WBInteraction000418825
WBInteraction000419719
WBInteraction000422102
WBInteraction000425946
WBInteraction000426522
WBInteraction000427360
WBInteraction000429236
WBInteraction000432227
WBInteraction000439098
WBInteraction000439818
WBInteraction000440581
WBInteraction000443752
WBInteraction000445031
WBInteraction000445663
WBInteraction000446129
WBInteraction000446945
WBInteraction000448798
WBInteraction000448916
WBInteraction000449114
WBInteraction000449145
WBInteraction000449207
WBInteraction000450489
WBInteraction000453218
WBInteraction000454836
WBInteraction000456188
WBInteraction000456679
WBInteraction000456686
WBInteraction000461295
WBInteraction000507181
WBInteraction000508196
WBInteraction000508572
WBInteraction000508573
WBInteraction000508574
WBInteraction000508575
WBInteraction000508628
WBInteraction000508643
WBInteraction000508661
WBInteraction000508663
WBInteraction000508665
WBInteraction000513384
WBInteraction000513445
WBInteraction000525913
WBInteraction000527519
WBInteraction000527520
WBInteraction000527521
WBInteraction000527522
WBInteraction000527523
WBInteraction000527524
WBInteraction000529255
WBInteraction000529486
WBInteraction000530190
WBInteraction000531036
WBInteraction000532590
WBInteraction000547533
Map_infoMapVPosition6.28117Error0.001023
PositivePositive_cloneF56A12Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point132
839
1725
Multi_point (14)
Pos_neg_data297
2131
3132
4308
Reference (35)
MethodGene