WormBase Tree Display for Gene: WBGene00006775
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| WBGene00006775 | SMap | S_parent | Sequence | F56A12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-39 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F56A12.1 | ||||||||
| Molecular_name | F56A12.1 | ||||||||
| F56A12.1.1 | |||||||||
| CE37921 | |||||||||
| Other_name | mig-3 | ||||||||
| ceh-35 | Paper_evidence | WBPaper00024327 | |||||||
| CELE_F56A12.1 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | unc-39 | ||||||||
| DB_info | Database | AceView | gene | 5O855 | |||||
| WormQTL | gene | WBGene00006775 | |||||||
| WormFlux | gene | WBGene00006775 | |||||||
| OMIM | disease | 610896 | |||||||
| 160900 | |||||||||
| gene | 600963 | ||||||||
| NDB | locus_tag | CELE_F56A12.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006775|UniProtKB=O17894 | |||||||
| family | PTHR10390 | ||||||||
| NCBI | gene | 191623 | |||||||
| RefSeq | protein | NM_074162.3 | |||||||
| SwissProt | UniProtAcc | O17894 | |||||||
| UniProt_GCRP | UniProtAcc | O17894 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 09 Nov 2004 14:53:34 | WBPerson2970 | Event | Acquires_merge | WBGene00000456 | ||||
| Acquires_merge | WBGene00000456 | ||||||||
| Status | Live | ||||||||
| Gene_info (11) | |||||||||
| Disease_info | Experimental_model | DOID:11722 | Homo sapiens | Paper_evidence | WBPaper00024327 | ||||
| Accession_evidence | OMIM | 160900 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Oct 2013 00:00:00 | ||||||||
| DOID:14702 | Homo sapiens | Paper_evidence | WBPaper00024327 | ||||||
| Accession_evidence | OMIM | 610896 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 24 Oct 2013 00:00:00 | ||||||||
| Potential_model | DOID:0111424 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10891) | |||||
| Disease_relevance | Mutations in the human Six5 protein have been implicated in Myotonic dystrophy 1 (DM1), a highly variable disease characterized by progressive muscle wasting, eye cataracts, cardiac abnormalities, and insulin resistance; in C. elegans, mutants in unc-29 (e257), orthologous to human Six5, show uncoordinated movement, mesodermal defects, and neuronal developmental and pathfinding defects; these studies indicate that unc-29/Six5 may be involved in development of mesoderm and differentiation and migration of neurons; the variable expressivity and penetrance of unc-39 defects are reminiscent of the pleiotropy seen in DM1 patients; some of the unc-29 mutant defects (coelomocyte specification) could be rescued by a transgene containing Six domain and homeodomain coding region from human Six5, showing a functional conservation between unc-29 and Six5; these studies indicate that unc-29 serves as a model to study how Six5 plays a role in conditions leading to myotonic dystrophy. | Homo sapiens | Paper_evidence | WBPaper00024327 | |||||
| Accession_evidence | OMIM | 600963 | |||||||
| 160900 | |||||||||
| 610896 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 01 May 2014 00:00:00 | ||||||||
| Models_disease_asserted | WBDOannot00000238 | ||||||||
| WBDOannot00000299 | |||||||||
| Molecular_info | Corresponding_CDS | F56A12.1 | |||||||
| Corresponding_CDS_history | F56A12.1:wp137 | ||||||||
| Corresponding_transcript | F56A12.1.1 | ||||||||
| Other_sequence | Acan_isotig06578 | ||||||||
| Dviv_isotig15575 | |||||||||
| Dviv_isotig15576 | |||||||||
| Acan_isotig06577 | |||||||||
| Oden_isotig18067 | |||||||||
| Tcir_isotig25512 | |||||||||
| Oden_isotig25907 | |||||||||
| JI463737.1 | |||||||||
| Oden_isotig18066 | |||||||||
| JI211494.1 | |||||||||
| Associated_feature | WBsf647528 | ||||||||
| WBsf662081 | |||||||||
| WBsf662082 | |||||||||
| WBsf662083 | |||||||||
| WBsf978863 | |||||||||
| WBsf1001995 | |||||||||
| WBsf1020832 | |||||||||
| WBsf232919 | |||||||||
| WBsf232920 | |||||||||
| Gene_product_binds (218) | |||||||||
| Transcription_factor | WBTranscriptionFactor000219 | ||||||||
| Experimental_info | RNAi_result | WBRNAi00101784 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00032912 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089718 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090158 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090317 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061182 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00015762 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00048581 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00114716 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089999 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (12) | |||||||||
| Drives_construct | WBCnstr00004349 | ||||||||
| WBCnstr00011130 | |||||||||
| WBCnstr00012730 | |||||||||
| WBCnstr00015880 | |||||||||
| WBCnstr00016522 | |||||||||
| WBCnstr00034159 | |||||||||
| Construct_product | WBCnstr00011130 | ||||||||
| WBCnstr00015880 | |||||||||
| WBCnstr00016701 | |||||||||
| WBCnstr00034159 | |||||||||
| Regulate_expr_cluster | WBPaper00050496:unc-39(hp701)_regulated | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (153) | |||||||||
| Interaction (134) | |||||||||
| Map_info | Map | V | Position | 6.28117 | Error | 0.001023 | |||
| Positive | Positive_clone | F56A12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | 2_point | 132 | |||||||
| 839 | |||||||||
| 1725 | |||||||||
| Multi_point (14) | |||||||||
| Pos_neg_data | 297 | ||||||||
| 2131 | |||||||||
| 3132 | |||||||||
| 4308 | |||||||||
| Reference | WBPaper00000031 | ||||||||
| WBPaper00000608 | |||||||||
| WBPaper00000978 | |||||||||
| WBPaper00001304 | |||||||||
| WBPaper00001411 | |||||||||
| WBPaper00001461 | |||||||||
| WBPaper00001508 | |||||||||
| WBPaper00004825 | |||||||||
| WBPaper00004883 | |||||||||
| WBPaper00015049 | |||||||||
| WBPaper00015440 | |||||||||
| WBPaper00015723 | |||||||||
| WBPaper00016590 | |||||||||
| WBPaper00017575 | |||||||||
| WBPaper00018929 | |||||||||
| WBPaper00018930 | |||||||||
| WBPaper00023095 | |||||||||
| WBPaper00024327 | |||||||||
| WBPaper00027262 | |||||||||
| WBPaper00027309 | |||||||||
| WBPaper00029033 | |||||||||
| WBPaper00029053 | |||||||||
| WBPaper00029055 | |||||||||
| WBPaper00032446 | |||||||||
| WBPaper00033137 | |||||||||
| WBPaper00039624 | |||||||||
| WBPaper00047468 | |||||||||
| WBPaper00050496 | |||||||||
| WBPaper00056066 | |||||||||
| WBPaper00057619 | |||||||||
| WBPaper00058964 | |||||||||
| WBPaper00060123 | |||||||||
| WBPaper00061738 | |||||||||
| WBPaper00064421 | |||||||||
| WBPaper00064694 | |||||||||
| Method | Gene |
