| WBGene00006775 | SMap | S_parent | Sequence | F56A12 |
|---|
| Identity | Version | 2 |
| | Name | CGC_name | unc-39 | Person_evidence | WBPerson261 |
| | | Sequence_name | F56A12.1 |
| | | Molecular_name | F56A12.1 |
| | | | F56A12.1.1 |
| | | | CE37921 |
| | | Other_name | mig-3 |
| | | | ceh-35 | Paper_evidence | WBPaper00024327 |
| | | | CELE_F56A12.1 | Accession_evidence | NDB | BX284605 |
| | | Public_name | unc-39 |
| | DB_info | Database | AceView | gene | 5O855 |
| | | | WormQTL | gene | WBGene00006775 |
| | | | WormFlux | gene | WBGene00006775 |
| | | | OMIM | disease | 610896 |
| | | | | | 160900 |
| | | | | gene | 600963 |
| | | | NDB | locus_tag | CELE_F56A12.1 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006775|UniProtKB=O17894 |
| | | | | family | PTHR10390 |
| | | | NCBI | gene | 191623 |
| | | | RefSeq | protein | NM_074162.3 |
| | | | SwissProt | UniProtAcc | O17894 |
| | | | UniProt_GCRP | UniProtAcc | O17894 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:42 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 09 Nov 2004 14:53:34 | WBPerson2970 | Event | Acquires_merge | WBGene00000456 |
| | | Acquires_merge | WBGene00000456 |
| | Status | Live |
| Gene_info (11) |
| Disease_info | Experimental_model | DOID:11722 | Homo sapiens | Paper_evidence | WBPaper00024327 |
| | | | | Accession_evidence | OMIM | 160900 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 24 Oct 2013 00:00:00 |
| | | DOID:14702 | Homo sapiens | Paper_evidence | WBPaper00024327 |
| | | | | Accession_evidence | OMIM | 610896 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 24 Oct 2013 00:00:00 |
| | Potential_model | DOID:0111424 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:10891) |
| | Disease_relevance | Mutations in the human Six5 protein have been implicated in Myotonic dystrophy 1 (DM1), a highly variable disease characterized by progressive muscle wasting, eye cataracts, cardiac abnormalities, and insulin resistance; in C. elegans, mutants in unc-29 (e257), orthologous to human Six5, show uncoordinated movement, mesodermal defects, and neuronal developmental and pathfinding defects; these studies indicate that unc-29/Six5 may be involved in development of mesoderm and differentiation and migration of neurons; the variable expressivity and penetrance of unc-39 defects are reminiscent of the pleiotropy seen in DM1 patients; some of the unc-29 mutant defects (coelomocyte specification) could be rescued by a transgene containing Six domain and homeodomain coding region from human Six5, showing a functional conservation between unc-29 and Six5; these studies indicate that unc-29 serves as a model to study how Six5 plays a role in conditions leading to myotonic dystrophy. | Homo sapiens | Paper_evidence | WBPaper00024327 |
| | | | | Accession_evidence | OMIM | 600963 |
| | | | | | | 160900 |
| | | | | | | 610896 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 01 May 2014 00:00:00 |
| Models_disease_asserted | WBDOannot00000238 |
| | WBDOannot00000299 |
| Molecular_info | Corresponding_CDS | F56A12.1 |
| | Corresponding_CDS_history | F56A12.1:wp137 |
| | Corresponding_transcript | F56A12.1.1 |
| | Other_sequence | Acan_isotig06578 |
| | | Dviv_isotig15575 |
| | | Dviv_isotig15576 |
| | | Acan_isotig06577 |
| | | Oden_isotig18067 |
| | | Tcir_isotig25512 |
| | | Oden_isotig25907 |
| | | JI463737.1 |
| | | Oden_isotig18066 |
| | | JI211494.1 |
| | Associated_feature | WBsf647528 |
| | | WBsf662081 |
| | | WBsf662082 |
| | | WBsf662083 |
| | | WBsf978863 |
| | | WBsf1001995 |
| | | WBsf1020832 |
| | | WBsf232919 |
| | | WBsf232920 |
| | Gene_product_binds (218) |
| | Transcription_factor | WBTranscriptionFactor000219 |
| Experimental_info | RNAi_result | WBRNAi00101784 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00032912 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089718 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090158 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090317 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00061182 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00015762 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00048581 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00114716 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089999 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (12) |
| | Drives_construct | WBCnstr00004349 |
| | | WBCnstr00011130 |
| | | WBCnstr00012730 |
| | | WBCnstr00015880 |
| | | WBCnstr00016522 |
| | | WBCnstr00034159 |
| | Construct_product | WBCnstr00011130 |
| | | WBCnstr00015880 |
| | | WBCnstr00016701 |
| | | WBCnstr00034159 |
| | Regulate_expr_cluster | WBPaper00050496:unc-39(hp701)_regulated |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00024505:pharyngeal_enriched |
| | | WBPaper00033070:Rhine_upregulated |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq |
| | | WBPaper00038438:S.marcescens_24hr_downregulated_TilingArray |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040221:DAF-12_target_ALF9 |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044316:CH3HgCl_7.5uM_downregulated |
| | | WBPaper00044426:rotenone_5day_downregulated |
| | | WBPaper00044760:somatic_specific |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00048988:daf-16(mu86)_upregulated_neuron |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049377:MWCNT_downregulated |
| | | WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr) |
| | | WBPaper00049954:BPS_upregulated |
| | | WBPaper00050121:mir-60(n4947)_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00052868:ALA_downregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq |
| | | WBPaper00053321:embryo-to-L1_upregulated_WT_SMARTseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053402:his-3(RNAi)_upregulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00054758:alg-2(ok304)_downregulated |
| | | WBPaper00055013:spt-16(RNAi)_upregulated |
| | | WBPaper00055060:flr-1(RNAi)_upregulated |
| | | WBPaper00055354:Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rapamycin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055386:daf-2(e1370)_downregulated |
| | | WBPaper00055386:eat-2(ad465)_downregulated |
| | | WBPaper00055482:Tunicamycin_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_20C_upregulated |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056443:DietaryRestriction_upregulated |
| | | WBPaper00056446:hsb-1(cg116)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00057041:unc-70(cas983)_downregulated |
| | | WBPaper00057068:ints-4(RNAi)_upregulated |
| | | WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium |
| | | WBPaper00057265:metaformin_upregulated_OP50 |
| | | WBPaper00057265:metaformin_upregulated_OP50-MR |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058691:cfp-1(tm6369)_downregulated |
| | | WBPaper00058691:sin-3(tm1276)_downregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00059117:B.subtilis_upregulated |
| | | WBPaper00059224:tph-1(mg280)_upregulated |
| | | WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_downregulated |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060886:met-2(n4256)_upregulated |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:ASI_parent |
| | | WBPaper00061340:AVH_parent |
| | | WBPaper00061340:Ciliated_amphid_neuron |
| | | WBPaper00061340:Ciliated_non_amphid_neuron |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:IL2 |
| | | WBPaper00061340:Neuroblast_IL1_IL2 |
| | | WBPaper00061340:OLL_parent |
| | | WBPaper00061340:RIA_parent |
| | | WBPaper00061340:RID_parent |
| | | WBPaper00061340:Z1_Z4 |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061424:Diet_MYb120_downregulated |
| | | WBPaper00061424:Diet_MYb131_upregulated |
| | | WBPaper00061527:cfz-2_18944-cfz-2_2268 |
| | | WBPaper00061651:AIA_enriched |
| | | WBPaper00061651:IL2_LR_enriched |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00062590:Aging_upregulated_neuron |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00064769:him-17(me24)_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065005:sams-4(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day1_25C |
| | | WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:endu-2(tm4977)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:25_1 |
| | | WBPaper00065841:104_0 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066005:RAGA-1_degradation_somatic_upregulated |
| | | WBPaper00066093:E.coli-purE_downregulated |
| | | cgc4386_cluster_6_2 |
| | | cgc4489_group_5 |
| | | WBPaper00025032:cluster_16 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00032165:A_to_C_transit_increased |
| | | WBPaper00032165:differentially_expressed_with_age_medoid_1 |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036286:Pattern_F |
| | | WBPaper00036383:ash-2_Day8_regulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_aging |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00046639:tyrosol_upregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00056330:mrps-5(RNAi)_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:cluster_5 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(53_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(53_min) |
| | Interaction (134) |
| Map_info | Map | V | Position | 6.28117 | Error | 0.001023 |
| | Positive | Positive_clone | F56A12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 132 |
| | | | 839 |
| | | | 1725 |
| | | Multi_point (14) |
| | | Pos_neg_data | 297 |
| | | | 2131 |
| | | | 3132 |
| | | | 4308 |
| Reference | WBPaper00000031 |
| | WBPaper00000608 |
| | WBPaper00000978 |
| | WBPaper00001304 |
| | WBPaper00001411 |
| | WBPaper00001461 |
| | WBPaper00001508 |
| | WBPaper00004825 |
| | WBPaper00004883 |
| | WBPaper00015049 |
| | WBPaper00015440 |
| | WBPaper00015723 |
| | WBPaper00016590 |
| | WBPaper00017575 |
| | WBPaper00018929 |
| | WBPaper00018930 |
| | WBPaper00023095 |
| | WBPaper00024327 |
| | WBPaper00027262 |
| | WBPaper00027309 |
| | WBPaper00029033 |
| | WBPaper00029053 |
| | WBPaper00029055 |
| | WBPaper00032446 |
| | WBPaper00033137 |
| | WBPaper00039624 |
| | WBPaper00047468 |
| | WBPaper00050496 |
| | WBPaper00056066 |
| | WBPaper00057619 |
| | WBPaper00058964 |
| | WBPaper00060123 |
| | WBPaper00061738 |
| | WBPaper00064421 |
| | WBPaper00064694 |
| Method | Gene |
