e257 : fairly severe kinker can move forward and backward fairly active slightly dumpy. ES2 ME1. NA1.
ct73 : abnormal migration of CAN cells.
[C.elegansII] e257 : fairly severe kinker, can move forward and backward; fairly active, slightly dumpy; often withered tail as a result of80% CAN migration defect; other migrations also variably defective. 15% of hermaphrodites have third gonad arm arising from additional somatic gonad founder, "Z5". e257/Df more severe phenotypes. ES2 ME1. OA2: ct73 (pka mig-3,abnormal migration of CAN cells), rh72. [Hedgecock et al. 1987; Manser and Wood 1990; CF; NJ]
unc-39 encodes a homeodomain transcription factor that belongs to the Six4/5 family of homeodomain proteins that includes human Six5; UNC-39 is required for axonal pathfinding in anterior-derived neurons and for specification of most mesodermal cell types and may regulate a developmental decision between migration and differentiation; UNC-39 is expressed in the embryo in anterior neurons, posteriorly derived mesoderm (somatic gonad, M mesoblast, and possibly the coelomocytes and muIntR), the CAN neurons, and body wall muscle.
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including egg-laying behavior; generation of neurons; and regulation of locomotion. Located in nucleus. Expressed in several structures, including AIA; IL2 neuron; RID; coelomocyte; and neuroblasts. Used to study branchiootorenal syndrome and myotonic dystrophy type 1. Human ortholog(s) of this gene implicated in branchiootorenal syndrome 2. Is an ortholog of human SIX4 (SIX homeobox 4) and SIX5 (SIX homeobox 5).