WormBase Tree Display for Gene: WBGene00006786
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WBGene00006786 | SMap | S_parent | Sequence | Y60A3A | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143154 | ||||||
Allele (371) | |||||||
Legacy_information | e369 : paralysed dumpy tends to curl; Egl; dorsal extensions of DD and VD neurons grow in aberrant directions fail to connect to dorsal nerve cord; amphid phasmid PDE axons abnormal; suppressed by sup-4. ES3 ME0. NA6 (e389 e432 etc.). | ||||||
See also e432, e584, e1120, e1189, e1212 | |||||||
[C.elegansII] e369amb : paralysed dumpy tends to curl; Egl; dorsal extensions of DD and VD neurons grow in aberrant directions fail to connect to dorsal nerve cord; amphid, phasmid, PDE and other axons abnormal; multiple defects in axon elongation, fasciculation,etc. Abnormal axon ultrastructure: varicosities, cisternae, abnormal vesicles.ES3 ME0. OA>10: e389, e432, e584, e1212 etc. Cloned: 3.1 kb transcript, encodes predicted 856 aa protein with similarity to Ser/Thrkinases. unc-51: lacZ expressed in neurons. [Hedgecock et al. 1985; McIntire et al. 1992; Ogura et al. 1994; FK; FR] | |||||||
Strain (20) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (61) | |||||||
Ortholog (54) | |||||||
Paralog | WBGene00013694 | Caenorhabditis elegans | From_analysis | Panther | |||
WBGene00013643 | Caenorhabditis elegans | From_analysis | Panther | ||||
Structured_description | Concise_description | unc-51 encodes a serine/threonine protein kinase orthologous to Saccharomyces cerevisiae autophagy protein Atg1p and the vertebrate ULK proteins; unc-51 is required for axon outgrowth along the anterior-posterior axis and sex myoblast migration; in regulating axon outgrowth, UNC-51 functions together with the VAB-8 kinesin-like protein and UNC-14, both of which physically interact with, and are phosphorylated by, UNC-51, and with the UNC-5 Netrin receptor, whose subcellular localization in neurons is regulated by UNC-51 and UNC-14; in addition, UNC-51 is required for normal dauer morphogenesis of daf-2 mutant animals; UNC-51 is expressed in all C. elegans neurons and in body wall and pharyngeal muscles; in neurons, an UNC-51::GFP fusion protein shows punctate cytoplasmic localization in axons and cell bodies and partial co-localization with UNC-14 and UNC-5. | Paper_evidence | WBPaper00002050 | |||
WBPaper00002845 | |||||||
WBPaper00004362 | |||||||
WBPaper00006070 | |||||||
WBPaper00024595 | |||||||
WBPaper00028376 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 21 Jul 2008 00:00:00 | ||||||
Automated_description | Enables protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and regulation of axon extension. Located in axon and neuronal cell body. Expressed in body wall musculature; motor neurons; pharyngeal muscle cell; and touch receptor neurons. Is an ortholog of human ULK1 (unc-51 like autophagy activating kinase 1) and ULK2 (unc-51 like autophagy activating kinase 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | Y60A3A.1 | |||||
Corresponding_transcript | Y60A3A.1.1 | ||||||
Other_sequence (65) | |||||||
Associated_feature | WBsf669876 | ||||||
WBsf669877 | |||||||
WBsf982087 | |||||||
WBsf1003406 | |||||||
WBsf1021857 | |||||||
Experimental_info | RNAi_result (28) | ||||||
Expr_pattern | Expr731 | ||||||
Expr1492 | |||||||
Expr12441 | |||||||
Expr15294 | |||||||
Expr1021306 | |||||||
Expr1032857 | |||||||
Expr1161234 | |||||||
Expr2017884 | |||||||
Expr2036020 | |||||||
Drives_construct (17) | |||||||
Construct_product | WBCnstr00012519 | ||||||
WBCnstr00018490 | |||||||
WBCnstr00021075 | |||||||
Microarray_results (20) | |||||||
Expression_cluster (150) | |||||||
Interaction (96) | |||||||
WBProcess | WBbiopr:00000003 | ||||||
Map_info | Map | V | Position | 24.4326 | Error | 0.019149 | |
Well_ordered | |||||||
Positive | Inside_rearr | ozDf1 | |||||
ozDf2 | |||||||
Positive_clone | Y60A3A | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
YO#KOPUF | |||||||
Mapping_data | 2_point (12) | ||||||
Multi_point (36) | |||||||
Pos_neg_data | 298 | ||||||
2143 | |||||||
8972 | |||||||
8980 | |||||||
Landmark_gene | |||||||
Reference (191) | |||||||
Method | Gene |