WormBase Tree Display for Gene: WBGene00006794
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| WBGene00006794 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-60 | Person_evidence | WBPerson77 | |||||
| Sequence_name | C38C3.5 | ||||||||
| Molecular_name | C38C3.5 | ||||||||
| C38C3.5.1 | |||||||||
| CE20549 | |||||||||
| Other_name | unc-66 | ||||||||
| C38C3.f | Curator_confirmed | WBPerson1983 | |||||||
| Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
| CELE_C38C3.5 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | unc-60 | ||||||||
| DB_info | Database | AceView | gene | 5B957 | |||||
| WormQTL | gene | WBGene00006794 | |||||||
| WormFlux | gene | WBGene00006794 | |||||||
| NDB | locus_tag | CELE_C38C3.5 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006794|UniProtKB=Q07750 | |||||||
| family | PTHR11913 | ||||||||
| NCBI | gene | 178640 | |||||||
| RefSeq | protein | NM_071026.11 | |||||||
| SwissProt | UniProtAcc | Q07749 | |||||||
| OMIM | gene | 601443 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 06 Mar 2018 14:39:08 | WBPerson4025 | Event | Split_into | WBGene00302980 | ||||
| Split_into | WBGene00302980 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Laboratory | BC | ||||||||
| Reference_allele | WBVar00143431 | ||||||||
| Allele (103) | |||||||||
| Legacy_information | e723 : limp paralysed or very slow thin Egl; abnormal muscle ultrastructure with large aggregates of thin filaments; recessively suppressed by sup-12. ES3 ME0. NA > 10 (e677 (pka unc-66) e890 : both resemble e723 etc.). | ||||||||
| See unc-60. | |||||||||
| See also e677, e723, e890, s1310, s1586, s1983, s1986 | |||||||||
| [C.elegansII] e723 : limp paralysed or very slow, thin, Egl; abnormal muscle ultrastructure with large aggregates of thin filaments; recessively suppressed by sup-12. ES3 ME0. OA>10: e677 (pka unc-66), e890 (both resemble e723), e890, s1310 (induced on eT1), s1586 (500 bp deletion, larval lethal). Also r398, s1307 (both antidystrophic alleles). Cloned: 1.3 and 0.7 kb alternative transcripts encoding 165 aa and 152 aa predicted proteins with 38% identity, sharing only first exon and first methionine; both have similarity to actin depolymerizing proteins (cofilin, destrin). [Waterston et al. 1980; McKim et al. 1994; BC] | |||||||||
| Strain (24) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (28) | |||||||||
| Contained_in_operon | CEOP5600 | ||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00302980 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| Structured_description | Concise_description | unc-60 encodes two, tissue-specific isoforms of actin depolymerizing factor(ADF)/cofilin, actin-binding proteins that regulate actin filament dynamics; one UNC-60 isoform, UNC-60A, primarily binds G-actin, depolymerizes actin filaments, and inhibits actin polymerization; UNC-60A is essential during early embryonic development for polar body extrusion, cytokinesis, and embryonic patterning; UNC-60B, which does not inhibit actin polymerization, binds F- and G-actin and influences the rate of actin polymerization by the UNC-60B:actin ratio; UNC-60B is required for actin filament organization in body wall muscle, locomotion, and for efficient actin filament disassembly by UNC-78, an actin interactin protein 1 (AIP1) ortholog; UNC-60A and UNC-60B are differentially expressed: UNC-60A is found in oocytes, embryos, and the adult gonad and intestine, while UNC-60B is found in body wall muscle, the vulva, and spermatheca; unc-60 transcripts undergo muscle-specific pre-mRNA processing, regulated by the ASD-2 and SUP-12 splicing factors. | Paper_evidence | WBPaper00003001 | |||||
| WBPaper00005824 | |||||||||
| WBPaper00019545 | |||||||||
| WBPaper00019663 | |||||||||
| WBPaper00041641 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 06 Nov 2012 00:00:00 | ||||||||
| Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament-based process; embryo development; and positive regulation of actin filament polymerization. Located in striated muscle thin filament. Part of ribonucleoprotein complex. Expressed in several structures, including germ line; hermaphrodite gonad; nerve ring; oocyte; and vulva. Human ortholog(s) of this gene implicated in brain compression; gallbladder carcinoma; and nemaline myopathy 7. Is an ortholog of human CFL2 (cofilin 2). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:4948 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1874) | ||||
| DOID:0110934 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1875) | ||||||
| DOID:11457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1874) | ||||||
| Molecular_info | Corresponding_CDS | C38C3.5 | |||||||
| Corresponding_CDS_history | C38C3.5a:wp264 | ||||||||
| C38C3.5b:wp86 | |||||||||
| C38C3.5b:wp249 | |||||||||
| C38C3.5c:wp264 | |||||||||
| Corresponding_transcript | C38C3.5.1 | ||||||||
| Other_sequence (212) | |||||||||
| Associated_feature (19) | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00019150 | ||||||||
| WBCnstr00034145 | |||||||||
| Construct_product | WBCnstr00015454 | ||||||||
| WBCnstr00015473 | |||||||||
| WBCnstr00015475 | |||||||||
| WBCnstr00015476 | |||||||||
| WBCnstr00015477 | |||||||||
| WBCnstr00015478 | |||||||||
| WBCnstr00019150 | |||||||||
| WBCnstr00019151 | |||||||||
| WBCnstr00019152 | |||||||||
| WBCnstr00034145 | |||||||||
| Antibody (3) | |||||||||
| Microarray_results (24) | |||||||||
| Expression_cluster (166) | |||||||||
| Interaction (203) | |||||||||
| Anatomy_function | WBbtf0607 | ||||||||
| Map_info | Map | V | Position | -18.8768 | Error | 0.017792 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf28 | |||||||
| rT1 | |||||||||
| Positive_clone | C32E5 | ||||||||
| C38C3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| F53E2 | |||||||||
| Mapping_data | 2_point (13) | ||||||||
| Multi_point (29) | |||||||||
| Pos_neg_data | 1793 | ||||||||
| 1799 | |||||||||
| 1805 | |||||||||
| 2166 | |||||||||
| 3092 | |||||||||
| 3257 | |||||||||
| 3096 | |||||||||
| 3105 | |||||||||
| 3582 | |||||||||
| 5182 | |||||||||
| Landmark_gene | |||||||||
| Reference (119) | |||||||||
| Remark | [ Wakarchuck MF] dpy-18(e364)/eT1; unc-60(m35)/eT1 male was crossed to eT1(III;V); sEx9 [pRF4{rol-6(su1006)}+C32E5] hermaphrodite. F1 rollers segregated fertile Dpy non-Uncs among their progeny, indicating rescue of unc-60(m35). | ||||||||
| Method | Gene |
