WormBase Tree Display for Gene: WBGene00006794
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WBGene00006794 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | unc-60 | Person_evidence | WBPerson77 | |||||
Sequence_name | C38C3.5 | ||||||||
Molecular_name | C38C3.5 | ||||||||
C38C3.5.1 | |||||||||
CE20549 | |||||||||
Other_name | unc-66 | ||||||||
C38C3.f | Curator_confirmed | WBPerson1983 | |||||||
Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs | ||||||||
CELE_C38C3.5 | Accession_evidence | NDB | BX284605 | ||||||
Public_name | unc-60 | ||||||||
DB_info | Database (9) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
2 | 06 Mar 2018 14:39:08 | WBPerson4025 | Event | Split_into | WBGene00302980 | ||||
Split_into | WBGene00302980 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | unc | ||||||||
Laboratory | BC | ||||||||
Reference_allele | WBVar00143431 | ||||||||
Allele (103) | |||||||||
Legacy_information | e723 : limp paralysed or very slow thin Egl; abnormal muscle ultrastructure with large aggregates of thin filaments; recessively suppressed by sup-12. ES3 ME0. NA > 10 (e677 (pka unc-66) e890 : both resemble e723 etc.). | ||||||||
See unc-60. | |||||||||
See also e677, e723, e890, s1310, s1586, s1983, s1986 | |||||||||
[C.elegansII] e723 : limp paralysed or very slow, thin, Egl; abnormal muscle ultrastructure with large aggregates of thin filaments; recessively suppressed by sup-12. ES3 ME0. OA>10: e677 (pka unc-66), e890 (both resemble e723), e890, s1310 (induced on eT1), s1586 (500 bp deletion, larval lethal). Also r398, s1307 (both antidystrophic alleles). Cloned: 1.3 and 0.7 kb alternative transcripts encoding 165 aa and 152 aa predicted proteins with 38% identity, sharing only first exon and first methionine; both have similarity to actin depolymerizing proteins (cofilin, destrin). [Waterston et al. 1980; McKim et al. 1994; BC] | |||||||||
Strain (24) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (28) | |||||||||
Contained_in_operon | CEOP5600 | ||||||||
Ortholog (44) | |||||||||
Paralog | WBGene00302980 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
Structured_description | Concise_description | unc-60 encodes two, tissue-specific isoforms of actin depolymerizing factor(ADF)/cofilin, actin-binding proteins that regulate actin filament dynamics; one UNC-60 isoform, UNC-60A, primarily binds G-actin, depolymerizes actin filaments, and inhibits actin polymerization; UNC-60A is essential during early embryonic development for polar body extrusion, cytokinesis, and embryonic patterning; UNC-60B, which does not inhibit actin polymerization, binds F- and G-actin and influences the rate of actin polymerization by the UNC-60B:actin ratio; UNC-60B is required for actin filament organization in body wall muscle, locomotion, and for efficient actin filament disassembly by UNC-78, an actin interactin protein 1 (AIP1) ortholog; UNC-60A and UNC-60B are differentially expressed: UNC-60A is found in oocytes, embryos, and the adult gonad and intestine, while UNC-60B is found in body wall muscle, the vulva, and spermatheca; unc-60 transcripts undergo muscle-specific pre-mRNA processing, regulated by the ASD-2 and SUP-12 splicing factors. | Paper_evidence | WBPaper00003001 | |||||
WBPaper00005824 | |||||||||
WBPaper00019545 | |||||||||
WBPaper00019663 | |||||||||
WBPaper00041641 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 06 Nov 2012 00:00:00 | ||||||||
Automated_description | Enables actin filament binding activity. Involved in several processes, including actin filament-based process; embryo development; and positive regulation of actin filament polymerization. Located in striated muscle thin filament. Part of ribonucleoprotein complex. Expressed in several structures, including germ line; hermaphrodite gonad; nerve ring; oocyte; and vulva. Human ortholog(s) of this gene implicated in brain compression; gallbladder carcinoma; and nemaline myopathy 7. Is an ortholog of human CFL2 (cofilin 2). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:4948 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1874) | ||||
DOID:0110934 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1875) | ||||||
DOID:11457 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1874) | ||||||
Molecular_info | Corresponding_CDS | C38C3.5 | |||||||
Corresponding_CDS_history | C38C3.5a:wp264 | ||||||||
C38C3.5b:wp86 | |||||||||
C38C3.5b:wp249 | |||||||||
C38C3.5c:wp264 | |||||||||
Corresponding_transcript | C38C3.5.1 | ||||||||
Other_sequence (212) | |||||||||
Associated_feature (19) | |||||||||
Experimental_info | RNAi_result (17) | ||||||||
Expr_pattern (11) | |||||||||
Drives_construct | WBCnstr00019150 | ||||||||
WBCnstr00034145 | |||||||||
Construct_product | WBCnstr00015454 | ||||||||
WBCnstr00015473 | |||||||||
WBCnstr00015475 | |||||||||
WBCnstr00015476 | |||||||||
WBCnstr00015477 | |||||||||
WBCnstr00015478 | |||||||||
WBCnstr00019150 | |||||||||
WBCnstr00019151 | |||||||||
WBCnstr00019152 | |||||||||
WBCnstr00034145 | |||||||||
Antibody | WBAntibody00000222 | ||||||||
WBAntibody00000223 | |||||||||
WBAntibody00002955 | |||||||||
Microarray_results (24) | |||||||||
Expression_cluster (166) | |||||||||
Interaction (203) | |||||||||
Anatomy_function | WBbtf0607 | ||||||||
Map_info | Map | V | Position | -18.8768 | Error | 0.017792 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | sDf28 | |||||||
rT1 | |||||||||
Positive_clone | C32E5 | ||||||||
C38C3 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
F53E2 | |||||||||
Mapping_data | 2_point (13) | ||||||||
Multi_point (29) | |||||||||
Pos_neg_data | 1793 | ||||||||
1799 | |||||||||
1805 | |||||||||
2166 | |||||||||
3092 | |||||||||
3257 | |||||||||
3096 | |||||||||
3105 | |||||||||
3582 | |||||||||
5182 | |||||||||
Landmark_gene | |||||||||
Reference (119) | |||||||||
Remark | [ Wakarchuck MF] dpy-18(e364)/eT1; unc-60(m35)/eT1 male was crossed to eT1(III;V); sEx9 [pRF4{rol-6(su1006)}+C32E5] hermaphrodite. F1 rollers segregated fertile Dpy non-Uncs among their progeny, indicating rescue of unc-60(m35). | ||||||||
Method | Gene |