WormBase Tree Display for Gene: WBGene00006797
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| WBGene00006797 | SMap | S_parent | Sequence | Y110A7A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-63 | Person_evidence | WBPerson261 | |||||
| Sequence_name | Y110A7A.3 | ||||||||
| Molecular_name | Y110A7A.3 | ||||||||
| Y110A7A.3.1 | |||||||||
| CE30706 | |||||||||
| Other_name | lev-7 | ||||||||
| tmr-3 | |||||||||
| CELE_Y110A7A.3 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | unc-63 | ||||||||
| DB_info | Database | AceView | gene | 1F717 | |||||
| WormQTL | gene | WBGene00006797 | |||||||
| WormFlux | gene | WBGene00006797 | |||||||
| NDB | locus_tag | CELE_Y110A7A.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006797|UniProtKB=Q9N587 | |||||||
| family | PTHR18945 | ||||||||
| NCBI | gene | 172150 | |||||||
| RefSeq | protein | NM_059132.5 | |||||||
| SwissProt | UniProtAcc | Q9N587 | |||||||
| UniProt_GCRP | UniProtAcc | Q9N587 | |||||||
| OMIM | gene | 100690 | |||||||
| 100710 | |||||||||
| 100720 | |||||||||
| 100725 | |||||||||
| 100730 | |||||||||
| 118502 | |||||||||
| 118503 | |||||||||
| 118504 | |||||||||
| 118507 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Allele (119) | |||||||||
| Legacy_information (3) | |||||||||
| Strain (11) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (42) | |||||||||
| Ortholog (59) | |||||||||
| Paralog (100) | |||||||||
| Structured_description | Concise_description | unc-63 encodes an alpha subunit of a levamisole-sensitive nicotinic acetylcholine receptor (L-nAChR); UNC-63 is required for normal locomotion and regulation of egg-laying behavior, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-29 and LEV-1, non-alpha L-nAChR subunits, the resulting multimer can form levamisole-gated channels; UNC-63 is expressed in body wall muscles, vulval muscles, and a large number of ventral cord neurons; UNC-63 is a member of the UNC-38-like group of nAChR subunits. | Paper_evidence | WBPaper00000031 | |||||
| WBPaper00004660 | |||||||||
| WBPaper00005223 | |||||||||
| WBPaper00005594 | |||||||||
| WBPaper00024530 | |||||||||
| WBPaper00037697 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 07 Dec 2011 00:00:00 | ||||||||
| Automated_description | Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; cholinergic synaptic transmission; and regulation of multicellular organismal process. Located in neuromuscular junction and postsynaptic membrane. Expressed in ganglia; head muscle; motor neurons; non-striated muscle; and ventral nerve cord. Used to study alcohol use disorder and congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and lung disease (multiple). Is an ortholog of human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:1574 | Homo sapiens | Paper_evidence | WBPaper00045914 | ||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 06 Jun 2019 00:00:00 | ||||||||
| DOID:3635 | Homo sapiens | Paper_evidence | WBPaper00037697 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 23 Feb 2021 00:00:00 | ||||||||
| Potential_model (29) | |||||||||
| Models_disease_asserted | WBDOannot00000705 | ||||||||
| WBDOannot00000706 | |||||||||
| WBDOannot00000869 | |||||||||
| WBDOannot00000870 | |||||||||
| WBDOannot00000871 | |||||||||
| WBDOannot00000872 | |||||||||
| WBDOannot00000873 | |||||||||
| WBDOannot00000874 | |||||||||
| WBDOannot00000875 | |||||||||
| Molecular_info | Corresponding_CDS | Y110A7A.3 | |||||||
| Corresponding_transcript | Y110A7A.3.1 | ||||||||
| Other_sequence (49) | |||||||||
| Associated_feature | WBsf983609 | ||||||||
| WBsf983610 | |||||||||
| WBsf983611 | |||||||||
| WBsf983612 | |||||||||
| WBsf1009773 | |||||||||
| WBsf1009774 | |||||||||
| WBsf1009775 | |||||||||
| WBsf217630 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00004530 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00066522 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089742 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066395 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090027 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090345 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00055324 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090186 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00036556 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram2008 | ||||||||
| Expr3394 | |||||||||
| Expr3926 | |||||||||
| Expr6882 | |||||||||
| Expr10821 | |||||||||
| Expr1018874 | |||||||||
| Expr1032867 | |||||||||
| Expr1158864 | |||||||||
| Expr2017896 | |||||||||
| Expr2036032 | |||||||||
| Drives_construct | WBCnstr00000877 | ||||||||
| WBCnstr00003643 | |||||||||
| WBCnstr00006476 | |||||||||
| WBCnstr00006477 | |||||||||
| WBCnstr00008276 | |||||||||
| WBCnstr00009871 | |||||||||
| WBCnstr00011375 | |||||||||
| WBCnstr00011753 | |||||||||
| WBCnstr00017749 | |||||||||
| Construct_product | WBCnstr00000877 | ||||||||
| WBCnstr00006476 | |||||||||
| WBCnstr00006477 | |||||||||
| WBCnstr00006571 | |||||||||
| WBCnstr00007478 | |||||||||
| WBCnstr00008274 | |||||||||
| WBCnstr00008275 | |||||||||
| WBCnstr00008276 | |||||||||
| WBCnstr00008277 | |||||||||
| WBCnstr00008278 | |||||||||
| WBCnstr00011753 | |||||||||
| WBCnstr00018657 | |||||||||
| Antibody | WBAntibody00001429 | ||||||||
| WBAntibody00002210 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (112) | |||||||||
| Interaction | WBInteraction000164160 | ||||||||
| WBInteraction000503664 | |||||||||
| WBInteraction000518472 | |||||||||
| WBInteraction000518495 | |||||||||
| WBInteraction000536782 | |||||||||
| WBInteraction000540194 | |||||||||
| WBInteraction000541906 | |||||||||
| WBInteraction000541922 | |||||||||
| WBInteraction000543440 | |||||||||
| Map_info | Map | I | Position | -0.35206 | |||||
| Well_ordered | |||||||||
| Positive | Positive_clone | Y72E2 | |||||||
| Y110A7A | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 9 | |||||||
| 209 | |||||||||
| 210 | |||||||||
| 245 | |||||||||
| 246 | |||||||||
| 410 | |||||||||
| 614 | |||||||||
| 2501 | |||||||||
| Multi_point (11) | |||||||||
| Pos_neg_data (16) | |||||||||
| Reference (119) | |||||||||
| Remark | Sequence connection from [Culetto E, Sattelle DB] (via JAH) | ||||||||
| [140923 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. | |||||||||
| Method | Gene |
