WormBase Tree Display for Gene: WBGene00006802
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WBGene00006802 | SMap | S_parent | Sequence | T07A5 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143321 | ||||||
Allele (18) | |||||||
Legacy_information | e587 : medium coiler inactive small; abnormalities in VD and DD commissures. ES3 ME0. NA2 (e602). | ||||||
[C.elegansII] e587 : medium coiler, inactive, small; abnormalities in VD and DD commissures, longitudinal axon elongation. ES3 ME0. OA1: e602. Cloned: cosmid rescue (C46D2). [Brenner 1974; NG; SQ; WS] | |||||||
Strain (16) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00005135 | ||||||
00005136 | |||||||
00005137 | |||||||
00005138 | |||||||
00005139 | |||||||
00005140 | |||||||
00005141 | |||||||
00005142 | |||||||
00005143 | |||||||
Ortholog (36) | |||||||
Structured_description | Concise_description | unc-69 encodes, by alternative splicing, three isoforms of a small (102- to 176-residue) coiled-coil protein required for normal axonal extension, axonal guidance, neuronal fasciculation, and synaptic vesicle localization; UNC-69 is orthologous to human SCOCO, which can transgenically rescue the locomotion defect of strong unc-69 mutants; UNC-69 is expressed in embryos, the processes and growth cones of immature neurons, and in the cell bodies of many (perhaps all) mature neurons; UNC-69 acts cell-autonomously in at least touch neurons, and perhaps all neurons; since UNC-69 binds a 19-residue conserved coiled-coil domain of UNC-76, UNC-69 and UNC-76 colocalize to neuronal puncta, unc-69 mutants phenotypically resemble unc-76, and mutations of these genes have nonallelic noncomplementation, UNC-69 and UNC-76 are likely to function as a complex. | Paper_evidence | WBPaper00000031 | |||
WBPaper00001345 | |||||||
WBPaper00002837 | |||||||
WBPaper00027646 | |||||||
WBPaper00027651 | |||||||
WBPaper00031100 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 18 Oct 2007 00:00:00 | ||||||
Automated_description | Involved in regulation of axon extension and regulation of synapse organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in CAN; HSN; ganglia; somatic nervous system; and touch receptor neurons. Is an ortholog of human SCOC (short coiled-coil protein). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T07A5.6a | |||||
T07A5.6b | |||||||
T07A5.6c | |||||||
Corresponding_transcript | T07A5.6a.1 | ||||||
T07A5.6b.1 | |||||||
T07A5.6c.1 | |||||||
Other_sequence (59) | |||||||
Associated_feature (12) | |||||||
Experimental_info | RNAi_result | WBRNAi00035291 | Inferred_automatically | RNAi_primary | |||
WBRNAi00062360 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr4900 | ||||||
Expr7838 | |||||||
Expr1016022 | |||||||
Expr1032870 | |||||||
Expr1156304 | |||||||
Expr2017899 | |||||||
Expr2036035 | |||||||
Drives_construct | WBCnstr00001400 | ||||||
WBCnstr00012320 | |||||||
WBCnstr00012950 | |||||||
Construct_product | WBCnstr00001400 | ||||||
WBCnstr00012320 | |||||||
WBCnstr00012950 | |||||||
Microarray_results (25) | |||||||
Expression_cluster (123) | |||||||
Interaction | WBInteraction000008990 | ||||||
WBInteraction000522715 | |||||||
WBInteraction000522716 | |||||||
WBInteraction000547046 | |||||||
Map_info | Map | III | Position | 2.3102 | Error | 0.00237 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDf40 | |||||
Positive_clone | T07A5 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Negative | Outside_rearr | tnDf2 | |||||
Mapping_data | 2_point | 72 | |||||
578 | |||||||
702 | |||||||
5137 | |||||||
6121 | |||||||
Multi_point (75) | |||||||
Pos_neg_data | 362 | ||||||
669 | |||||||
1597 | |||||||
1620 | |||||||
4768 | |||||||
8638 | |||||||
9454 | |||||||
10533 | |||||||
Reference (52) | |||||||
Remark | on same cosmid as unc-50; genetic map data indicate unc-69 left of unc-50 JAH 01/01 | ||||||
Method | Gene |