WormBase Tree Display for Gene: WBGene00006807

WBGene00006807 Evidence: Paper_evidence: WBPaper00012816
  SMap: S_parent: Sequence: C17D12
  Identity: Version: 1
    Name: CGC_name: unc-75 Person_evidence: WBPerson261
      Sequence_name: C17D12.2
      Molecular_name (12)
      Other_name: CELE_C17D12.2 Accession_evidence: NDB BX284601
      Public_name: unc-75
    DB_info: Database: AceView gene 1M191
        WormQTL gene WBGene00006807
        WormFlux gene WBGene00006807
        NDB locus_tag CELE_C17D12.2
        Panther gene CAEEL|WormBase=WBGene00006807|UniProtKB=G5EE68
          family PTHR24012
        NCBI gene 182722
        RefSeq protein NM_001313479.3
            NM_001313478.3
            NM_001313480.3
            NM_060557.7
        TrEMBL UniProtAcc A0A0K3AR68
            A0A0K3AWH2
            G5EE68
            A0A0K3ATM0
        UniProt_GCRP UniProtAcc G5EE68
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143628
    Allele: WBVar00143628 Inferred_automatically (13)
      WBVar02148985 Inferred_automatically: From strain object: FX30258
      WBVar01473865
      WBVar01473866
      WBVar00088840
      WBVar00088839
      WBVar00088842
      WBVar00088838
      WBVar02159247
      WBVar00267315
      WBVar01641158
      WBVar00088837
      WBVar00088843
      WBVar00088844
      WBVar00088845
      WBVar00088846
      WBVar00088847
      WBVar00088855
      WBVar02001993
      WBVar02001994
      WBVar02001995
      WBVar02001996
      WBVar02001997
      WBVar02001998
      WBVar02002000
      WBVar00673493
      WBVar00673494
      WBVar00673495
      WBVar00673496
      WBVar00673497
      WBVar00673498
      WBVar00673499
      WBVar00673500
      WBVar00673501
      WBVar00305003
      WBVar00673502
      WBVar00673503
      WBVar00673504
      WBVar00673505
      WBVar00673506
      WBVar00673507
      WBVar02128560
      WBVar00673508
      WBVar01499739
      WBVar01473932
      WBVar02128561
      WBVar02128562
      WBVar01473933
      WBVar00673509
      WBVar00673510
      WBVar01473934
      WBVar01473935
      WBVar00673511
      WBVar01473936
      WBVar00673512
      WBVar00673513
      WBVar01473937
      WBVar01473938
      WBVar00673514
      WBVar01473939
      WBVar00673515
      WBVar00673516
      WBVar01473940
      WBVar01473941
      WBVar00673517
      WBVar01473942
      WBVar00673518
      WBVar00673519
      WBVar01473943
      WBVar00673520
      WBVar01473944
      WBVar01473945
      WBVar00673521
      WBVar01339451
      WBVar00673522
      WBVar02120100
      WBVar00673523
      WBVar00673524
      WBVar00673525
      WBVar00673526
      WBVar01285147
      WBVar00673527
      WBVar00673528
      WBVar01285148
      WBVar01285149
      WBVar00673529
      WBVar01285150
      WBVar00673530
      WBVar01894814
      WBVar01285152
      WBVar00673531
      WBVar01392162
      WBVar01285153
      WBVar00673532
      WBVar01392163
      WBVar02097289
      WBVar00673533
      WBVar01285155
      WBVar01392164
      WBVar01349456
      WBVar01392165
      WBVar00673534
      WBVar01285157
      WBVar01392166
      WBVar00673535
      WBVar01285158
      WBVar01476213
      WBVar00673536
      WBVar01285159
      WBVar01285160
      WBVar00673537
      WBVar01285161
      WBVar00673538
      WBVar01473976
      WBVar00673539
      WBVar01285163
      WBVar00673540
      WBVar01285164
      WBVar01285165
      WBVar00673541
      WBVar00673542
      WBVar01285168
      WBVar01285169
      WBVar00673543
      WBVar01285172
      WBVar00673544
      WBVar00673545
      WBVar00673546
      WBVar00673547
      WBVar00673548
      WBVar01532278
      WBVar00673549
      WBVar01532279
      WBVar00673550
      WBVar01532280
      WBVar00539583
      WBVar00673551
      WBVar00346310
      WBVar00539586
      WBVar00673552
      WBVar00346311
      WBVar00346312
      WBVar00673553
      WBVar00539591
      WBVar00539595
      WBVar00673554
      WBVar00346313
      WBVar00346314
      WBVar00673555
      WBVar00346315
      WBVar00673556
      WBVar00673557
      WBVar00346316
      WBVar01499788
      WBVar00157413
      WBVar00346317
      WBVar00157414
      WBVar00673558
      WBVar00673559
      WBVar00157415
      WBVar00346318
      WBVar01499054
      WBVar00673560
      WBVar00157416
      WBVar00346319
      WBVar01489303
      WBVar00157417
      WBVar00346320
      WBVar00346321
      WBVar00157418
      WBVar00157419
      WBVar00346322
      WBVar00346323
      WBVar00157420
      WBVar00157421
      WBVar00346324
      WBVar00157422
      WBVar01957839
      WBVar00346325
      WBVar00346326
      WBVar00157423
      WBVar00157424
      WBVar00157425
      WBVar00157426
      WBVar00157427
      WBVar01890195
      WBVar00157428
      WBVar01890196
      WBVar00157429
      WBVar01890197
      WBVar01890198
      WBVar01890199
      WBVar01890200
      WBVar01890201
      WBVar01890202
      WBVar01574098
      WBVar01890203
      WBVar01890204
      WBVar01574099
      WBVar01574100
      WBVar01890205
      WBVar01433204
      WBVar01890206
      WBVar01433205
      WBVar01890207
      WBVar01433206
      WBVar01663588
      WBVar01663589
      WBVar01663590
      WBVar01663591
      WBVar01663592
      WBVar01663593
      WBVar01663594
      WBVar01663595
      WBVar01663596
      WBVar01424090
      WBVar01663597
      WBVar01663598
      WBVar01663599
      WBVar01663600
      WBVar01663601
      WBVar01663602
      WBVar01932640
      WBVar00306193
      WBVar02016453
      WBVar02088719
      WBVar02016454
      WBVar02066464
      WBVar01713248
      WBVar01713249
      WBVar01411848
      WBVar01713250
      WBVar01713251
      WBVar01713252
      WBVar01713253
      WBVar01713254
      WBVar01911920
      WBVar01911921
      WBVar01911922
      WBVar01911923
      WBVar01345978
      WBVar01345989
      WBVar00309645
      WBVar01346000
      WBVar01403538
      WBVar01346011
      WBVar01346022
      WBVar02033029
      WBVar02073765
      WBVar01498959
    Legacy_information: e950 : weak coiler especially in reverse; moves forward well; sluggish; short. ES3 ME2. NA1.
      [C.elegansII] e950 : weak coiler especially in reverse; moves forward well; sluggish; short; Ric. ES3 ME2. OA2: h1041, h1042 (both lethal)[Brenner 1974; Nguyen et al. 1995; KR; RM]
    Strain (32)
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (59)
    Paralog: WBGene00001340 Caenorhabditis elegans From_analysis: Inparanoid_8
      WBGene00017135 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00017140 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019510 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00019881 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00020354 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM that is orthologous to the mammalian CELF/BrunoL proteins that control pre-mRNA splicing; UNC-75 is required for neuron-specific splicing of unc-32 mRNA; UNC-75 binds the unc-32 intron 7a in vitro; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission; UNC-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates. Paper_evidence: WBPaper00006029
            WBPaper00012816
            WBPaper00042088
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 26 Mar 2013 00:00:00
      Automated_description: Enables single-stranded RNA binding activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of synaptic transmission; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Expressed in neurons and pharyngeal gland cell. Is an ortholog of human CELF5 (CUGBP Elav-like family member 5) and CELF6 (CUGBP Elav-like family member 6). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: C17D12.2a
      C17D12.2b
      C17D12.2c
      C17D12.2d
    Corresponding_CDS_history: C17D12.2:wp76
      C17D12.2:wp103
      C17D12.2:wp114
    Corresponding_transcript: C17D12.2a.1
      C17D12.2b.1
      C17D12.2c.1
      C17D12.2d.1
    Other_sequence (21)
    Associated_feature (15)
  Experimental_info: RNAi_result: WBRNAi00002963 Inferred_automatically: RNAi_primary
      WBRNAi00089748 Inferred_automatically: RNAi_primary
      WBRNAi00002961 Inferred_automatically: RNAi_primary
      WBRNAi00028998 Inferred_automatically: RNAi_primary
      WBRNAi00040789 Inferred_automatically: RNAi_primary
      WBRNAi00090164 Inferred_automatically: RNAi_primary
      WBRNAi00116889 Inferred_automatically: RNAi_primary
      WBRNAi00090323 Inferred_automatically: RNAi_primary
      WBRNAi00090005 Inferred_automatically: RNAi_primary
      WBRNAi00040788 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr2668
      Expr2669
      Expr1013866
      Expr1032874
      Expr1144828
      Expr2017904
      Expr2036040
    Drives_construct: WBCnstr00010893
      WBCnstr00010894
      WBCnstr00016124
    Construct_product: WBCnstr00010894
      WBCnstr00022989
      WBCnstr00022991
    Regulate_expr_cluster: WBPaper00049626:UNC-75_target
    Antibody: WBAntibody00002411
    Microarray_results (21)
    Expression_cluster (160)
    Interaction (33)
    Anatomy_function: WBbtf0228
      WBbtf0229
  Map_info: Map: I Position: 9.28192 Error: 0.021291
    Well_ordered
    Positive: Inside_rearr: nDp4
      Positive_clone: C17D12 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Outside_rearr: dxDf2
    Mapping_data: 2_point (17)
      Multi_point (79)
      Pos_neg_data (20)
    Landmark_gene
  Reference (63)
  Method: Gene