| WBGene00006807 | Evidence | Paper_evidence | WBPaper00012816 |
|---|
| SMap | S_parent | Sequence | C17D12 |
| Identity | Version | 1 |
| | Name | CGC_name | unc-75 | Person_evidence | WBPerson261 |
| | | Sequence_name | C17D12.2 |
| | | Molecular_name (12) |
| | | Other_name | CELE_C17D12.2 | Accession_evidence | NDB | BX284601 |
| | | Public_name | unc-75 |
| | DB_info | Database | AceView | gene | 1M191 |
| | | | WormQTL | gene | WBGene00006807 |
| | | | WormFlux | gene | WBGene00006807 |
| | | | NDB | locus_tag | CELE_C17D12.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006807|UniProtKB=G5EE68 |
| | | | | family | PTHR24012 |
| | | | NCBI | gene | 182722 |
| | | | RefSeq | protein | NM_001313479.3 |
| | | | | | NM_001313478.3 |
| | | | | | NM_001313480.3 |
| | | | | | NM_060557.7 |
| | | | TrEMBL | UniProtAcc | A0A0K3AR68 |
| | | | | | A0A0K3AWH2 |
| | | | | | G5EE68 |
| | | | | | A0A0K3ATM0 |
| | | | UniProt_GCRP | UniProtAcc | G5EE68 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143628 |
| | Allele (250) |
| | Legacy_information | e950 : weak coiler especially in reverse; moves forward well; sluggish; short. ES3 ME2. NA1. |
| | | [C.elegansII] e950 : weak coiler especially in reverse; moves forward well; sluggish; short; Ric. ES3 ME2. OA2: h1041, h1042 (both lethal)[Brenner 1974; Nguyen et al. 1995; KR; RM] |
| | Strain (32) |
| | RNASeq_FPKM (74) |
| | GO_annotation (20) |
| | Ortholog (59) |
| | Paralog | WBGene00001340 | Caenorhabditis elegans | From_analysis | Inparanoid_8 |
| | | WBGene00017135 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00017140 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00019510 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00019881 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00020354 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM that is orthologous to the mammalian CELF/BrunoL proteins that control pre-mRNA splicing; UNC-75 is required for neuron-specific splicing of unc-32 mRNA; UNC-75 binds the unc-32 intron 7a in vitro; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission; UNC-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates. | Paper_evidence | WBPaper00006029 |
| | | | | | WBPaper00012816 |
| | | | | | WBPaper00042088 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 26 Mar 2013 00:00:00 |
| | | Automated_description | Enables single-stranded RNA binding activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of synaptic transmission; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Expressed in neurons and pharyngeal gland cell. Is an ortholog of human CELF5 (CUGBP Elav-like family member 5) and CELF6 (CUGBP Elav-like family member 6). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | C17D12.2a |
| | | C17D12.2b |
| | | C17D12.2c |
| | | C17D12.2d |
| | Corresponding_CDS_history | C17D12.2:wp76 |
| | | C17D12.2:wp103 |
| | | C17D12.2:wp114 |
| | Corresponding_transcript | C17D12.2a.1 |
| | | C17D12.2b.1 |
| | | C17D12.2c.1 |
| | | C17D12.2d.1 |
| | Other_sequence (21) |
| | Associated_feature (15) |
| Experimental_info | RNAi_result | WBRNAi00002963 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00089748 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00002961 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00028998 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00040789 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090164 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00116889 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090323 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00090005 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00040788 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr2668 |
| | | Expr2669 |
| | | Expr1013866 |
| | | Expr1032874 |
| | | Expr1144828 |
| | | Expr2017904 |
| | | Expr2036040 |
| | Drives_construct | WBCnstr00010893 |
| | | WBCnstr00010894 |
| | | WBCnstr00016124 |
| | Construct_product | WBCnstr00010894 |
| | | WBCnstr00022989 |
| | | WBCnstr00022991 |
| | Regulate_expr_cluster | WBPaper00049626:UNC-75_target |
| | Antibody | WBAntibody00002411 |
| | Microarray_results (21) |
| | Expression_cluster | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00044260:1-methylnicotinamide_downregulated |
| | | WBPaper00044260:nicotic-acid_downregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045390:ubc-9(RNAi)_downregulated |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053606:N2_vs_elt-7(tm840)_upregulated |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00055648:nerve-ring_expressed |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056167:Cry5B_upregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_embryo |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059735:glucose_upregulated_lpin-1(RNAi) |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:let-418(n3536)_upregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ASE_parent |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:CEP |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:I5 |
| | | WBPaper00061340:M4_parent |
| | | WBPaper00061340:Neuroblast_ADF_AWB |
| | | WBPaper00061340:Neuroblast_AIZ_FLP |
| | | WBPaper00061340:Neuroblast_ASG_AWA |
| | | WBPaper00061340:Neuroblast_ASH_RIB |
| | | WBPaper00061340:OLQ_grandparent |
| | | WBPaper00061340:OLQ_parent |
| | | WBPaper00061340:Parent_of_exc_gland_AVK |
| | | WBPaper00061340:PVQ_parent |
| | | WBPaper00061340:PVR |
| | | WBPaper00061340:RIA_parent |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIM_parent |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:SIB |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated |
| | | WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:hrde-1(tm1200)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:hlh-30_18579-unc-43_21739 |
| | | WBPaper00061753:csr-1(tor159)_upregulated_25C |
| | | WBPaper00061902:camt-1(ok515)_regulated_RMG |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062056:lin-15B(we23)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_downregulated_germline |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062167:mbl-1(tm1563)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064509:static-magnetic-field_downregulated |
| | | WBPaper00064871:hypoxia_downregulated_F2 |
| | | WBPaper00065029:cadmium_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:6_0 |
| | | WBPaper00065841:6_1 |
| | | WBPaper00065841:14_1 |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:32_0 |
| | | WBPaper00065841:40_0 |
| | | WBPaper00065841:52_0 |
| | | WBPaper00065841:98_0 |
| | | WBPaper00065841:111_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066232:ash-2(RNAi)_upregulated_WT |
| | | cgc4489_group_17 |
| | | cgc4489_group_19 |
| | | WBPaper00037113:Diazinon_16C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00045673:colistin_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | Interaction (33) |
| | Anatomy_function | WBbtf0228 |
| | | WBbtf0229 |
| Map_info | Map | I | Position | 9.28192 | Error | 0.021291 |
| | Well_ordered |
| | Positive | Inside_rearr | nDp4 |
| | | Positive_clone | C17D12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Negative | Outside_rearr | dxDf2 |
| | Mapping_data | 2_point (17) |
| | | Multi_point (79) |
| | | Pos_neg_data (20) |
| | Landmark_gene |
| Reference (63) |
| Method | Gene |
