WormBase Tree Display for Gene: WBGene00006807
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| WBGene00006807 | Evidence | Paper_evidence | WBPaper00012816 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | C17D12 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-75 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C17D12.2 | ||||||||
| Molecular_name (12) | |||||||||
| Other_name | CELE_C17D12.2 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | unc-75 | ||||||||
| DB_info | Database | AceView | gene | 1M191 | |||||
| WormQTL | gene | WBGene00006807 | |||||||
| WormFlux | gene | WBGene00006807 | |||||||
| NDB | locus_tag | CELE_C17D12.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006807|UniProtKB=G5EE68 | |||||||
| family | PTHR24012 | ||||||||
| NCBI | gene | 182722 | |||||||
| RefSeq | protein | NM_001313479.3 | |||||||
| NM_001313478.3 | |||||||||
| NM_001313480.3 | |||||||||
| NM_060557.7 | |||||||||
| TrEMBL | UniProtAcc | A0A0K3AR68 | |||||||
| A0A0K3AWH2 | |||||||||
| G5EE68 | |||||||||
| A0A0K3ATM0 | |||||||||
| UniProt_GCRP | UniProtAcc | G5EE68 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143628 | ||||||||
| Allele (250) | |||||||||
| Legacy_information | e950 : weak coiler especially in reverse; moves forward well; sluggish; short. ES3 ME2. NA1. | ||||||||
| [C.elegansII] e950 : weak coiler especially in reverse; moves forward well; sluggish; short; Ric. ES3 ME2. OA2: h1041, h1042 (both lethal)[Brenner 1974; Nguyen et al. 1995; KR; RM] | |||||||||
| Strain (32) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (59) | |||||||||
| Paralog | WBGene00001340 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||||
| WBGene00017135 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017140 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019510 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019881 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00020354 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM that is orthologous to the mammalian CELF/BrunoL proteins that control pre-mRNA splicing; UNC-75 is required for neuron-specific splicing of unc-32 mRNA; UNC-75 binds the unc-32 intron 7a in vitro; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission; UNC-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates. | Paper_evidence | WBPaper00006029 | |||||
| WBPaper00012816 | |||||||||
| WBPaper00042088 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 26 Mar 2013 00:00:00 | ||||||||
| Automated_description | Enables single-stranded RNA binding activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of synaptic transmission; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Expressed in neurons and pharyngeal gland cell. Is an ortholog of human CELF5 (CUGBP Elav-like family member 5) and CELF6 (CUGBP Elav-like family member 6). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C17D12.2a | |||||||
| C17D12.2b | |||||||||
| C17D12.2c | |||||||||
| C17D12.2d | |||||||||
| Corresponding_CDS_history | C17D12.2:wp76 | ||||||||
| C17D12.2:wp103 | |||||||||
| C17D12.2:wp114 | |||||||||
| Corresponding_transcript | C17D12.2a.1 | ||||||||
| C17D12.2b.1 | |||||||||
| C17D12.2c.1 | |||||||||
| C17D12.2d.1 | |||||||||
| Other_sequence (21) | |||||||||
| Associated_feature (15) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00002963 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00089748 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00002961 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00028998 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040789 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090164 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00116889 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090323 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090005 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00040788 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr2668 | ||||||||
| Expr2669 | |||||||||
| Expr1013866 | |||||||||
| Expr1032874 | |||||||||
| Expr1144828 | |||||||||
| Expr2017904 | |||||||||
| Expr2036040 | |||||||||
| Drives_construct | WBCnstr00010893 | ||||||||
| WBCnstr00010894 | |||||||||
| WBCnstr00016124 | |||||||||
| Construct_product | WBCnstr00010894 | ||||||||
| WBCnstr00022989 | |||||||||
| WBCnstr00022991 | |||||||||
| Regulate_expr_cluster | WBPaper00049626:UNC-75_target | ||||||||
| Antibody | WBAntibody00002411 | ||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (160) | |||||||||
| Interaction | WBInteraction000005433 | ||||||||
| WBInteraction000008824 | |||||||||
| WBInteraction000009622 | |||||||||
| WBInteraction000035024 | |||||||||
| WBInteraction000035940 | |||||||||
| WBInteraction000036351 | |||||||||
| WBInteraction000048450 | |||||||||
| WBInteraction000048451 | |||||||||
| WBInteraction000048452 | |||||||||
| WBInteraction000049032 | |||||||||
| WBInteraction000126604 | |||||||||
| WBInteraction000140900 | |||||||||
| WBInteraction000140901 | |||||||||
| WBInteraction000150157 | |||||||||
| WBInteraction000229514 | |||||||||
| WBInteraction000271250 | |||||||||
| WBInteraction000297575 | |||||||||
| WBInteraction000301444 | |||||||||
| WBInteraction000311028 | |||||||||
| WBInteraction000356745 | |||||||||
| WBInteraction000393800 | |||||||||
| WBInteraction000422440 | |||||||||
| WBInteraction000437442 | |||||||||
| WBInteraction000446257 | |||||||||
| WBInteraction000450898 | |||||||||
| WBInteraction000524439 | |||||||||
| WBInteraction000547276 | |||||||||
| WBInteraction000547292 | |||||||||
| WBInteraction000547293 | |||||||||
| WBInteraction000547294 | |||||||||
| WBInteraction000547295 | |||||||||
| WBInteraction000547296 | |||||||||
| WBInteraction000573612 | |||||||||
| Anatomy_function | WBbtf0228 | ||||||||
| WBbtf0229 | |||||||||
| Map_info | Map | I | Position | 9.28192 | Error | 0.021291 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDp4 | |||||||
| Positive_clone | C17D12 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Negative | Outside_rearr | dxDf2 | |||||||
| Mapping_data | 2_point (17) | ||||||||
| Multi_point (79) | |||||||||
| Pos_neg_data (20) | |||||||||
| Landmark_gene | |||||||||
| Reference (63) | |||||||||
| Method | Gene |
