WormBase Tree Display for Gene: WBGene00006807
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WBGene00006807 | Evidence | Paper_evidence | WBPaper00012816 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | C17D12 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143628 | ||||||
Allele (250) | |||||||
Legacy_information | e950 : weak coiler especially in reverse; moves forward well; sluggish; short. ES3 ME2. NA1. | ||||||
[C.elegansII] e950 : weak coiler especially in reverse; moves forward well; sluggish; short; Ric. ES3 ME2. OA2: h1041, h1042 (both lethal)[Brenner 1974; Nguyen et al. 1995; KR; RM] | |||||||
Strain (32) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (20) | |||||||
Ortholog (59) | |||||||
Paralog | WBGene00001340 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | |||
WBGene00017135 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00017140 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019510 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00019881 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
WBGene00020354 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||
Structured_description | Concise_description | unc-75 encodes an RNA-binding protein with two N-terminal RNA recognition motifs (RRMs), a glutamine/asparagine-rich linker domain, and a third C-terminal RRM that is orthologous to the mammalian CELF/BrunoL proteins that control pre-mRNA splicing; UNC-75 is required for neuron-specific splicing of unc-32 mRNA; UNC-75 binds the unc-32 intron 7a in vitro; both UNC-75 and EXC-7 are required in parallel for normal cholinergic neurotransmission; UNC-75 is expressed in all neurons and in neurosecretory gland cells, and is required for normal modulation of GABA- and acetylcholine-mediated neurotransmission; UNC-75 protein is found with other RRM proteins in dynamic nuclear speckles, consistent with a role in alternative mRNA splicing; unc-75 mutations can be rescued in vivo by a human unc-75 transgene, but not by exc-7 or W02D3.11, indicating that UNC-75 acts on evolutionarily conserved but highly specific pre-mRNA substrates. | Paper_evidence | WBPaper00006029 | |||
WBPaper00012816 | |||||||
WBPaper00042088 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 26 Mar 2013 00:00:00 | ||||||
Automated_description | Enables single-stranded RNA binding activity. Involved in several processes, including cholinergic synaptic transmission; positive regulation of synaptic transmission; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Expressed in neurons and pharyngeal gland cell. Is an ortholog of human CELF5 (CUGBP Elav-like family member 5) and CELF6 (CUGBP Elav-like family member 6). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C17D12.2a | |||||
C17D12.2b | |||||||
C17D12.2c | |||||||
C17D12.2d | |||||||
Corresponding_CDS_history | C17D12.2:wp76 | ||||||
C17D12.2:wp103 | |||||||
C17D12.2:wp114 | |||||||
Corresponding_transcript | C17D12.2a.1 | ||||||
C17D12.2b.1 | |||||||
C17D12.2c.1 | |||||||
C17D12.2d.1 | |||||||
Other_sequence (21) | |||||||
Associated_feature (15) | |||||||
Experimental_info | RNAi_result | WBRNAi00002963 | Inferred_automatically | RNAi_primary | |||
WBRNAi00089748 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00002961 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00028998 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00040789 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090164 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00116889 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090323 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090005 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00040788 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr2668 | ||||||
Expr2669 | |||||||
Expr1013866 | |||||||
Expr1032874 | |||||||
Expr1144828 | |||||||
Expr2017904 | |||||||
Expr2036040 | |||||||
Drives_construct | WBCnstr00010893 | ||||||
WBCnstr00010894 | |||||||
WBCnstr00016124 | |||||||
Construct_product | WBCnstr00010894 | ||||||
WBCnstr00022989 | |||||||
WBCnstr00022991 | |||||||
Regulate_expr_cluster | WBPaper00049626:UNC-75_target | ||||||
Antibody | WBAntibody00002411 | ||||||
Microarray_results (21) | |||||||
Expression_cluster (160) | |||||||
Interaction (33) | |||||||
Anatomy_function | WBbtf0228 | ||||||
WBbtf0229 | |||||||
Map_info | Map | I | Position | 9.28192 | Error | 0.021291 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDp4 | |||||
Positive_clone | C17D12 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Negative | Outside_rearr | dxDf2 | |||||
Mapping_data | 2_point (17) | ||||||
Multi_point (79) | |||||||
Pos_neg_data (20) | |||||||
Landmark_gene | |||||||
Reference (63) | |||||||
Method | Gene |