Questions, Feedback & Help

Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006808

expand all nodes | collapse all nodes | view schema

WBGene00006808	SMap	S_parent	Sequence	C01G10
	Identity	Version	1
		Name	CGC_name	unc-76	Person_evidence	WBPerson261
			Sequence_name	C01G10.11
			Molecular_name (18)
			Other_name	CELE_C01G10.11	Accession_evidence	NDB	BX284605
			Public_name	unc-76
		DB_info	Database	AceView	gene	5P559
				WormQTL	gene	WBGene00006808
				WormFlux	gene	WBGene00006808
				NDB	locus_tag	CELE_C01G10.11
				Panther	gene	CAEEL\|WormBase=WBGene00006808\|UniProtKB=E0AHC6
					family	PTHR12394
				NCBI	gene	180014
				RefSeq	protein	NM_001269717.3
						NM_001269716.3
						NM_001269719.3
						NM_001269718.3
						NM_074311.7
						NM_171553.6
				TREEFAM	TREEFAM_ID	TF313128
				TrEMBL	UniProtAcc	E0AHC6
						E0AHC4
						E0AHC3
						E0AHC5
						Q7JL61
						Q7JL62
				UniProt_GCRP	UniProtAcc	E0AHC6
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:43	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	unc
		Reference_allele	WBVar00143591
		Allele (163)
		Legacy_information	e911pdi : inactive tends to curl dumpyish; Egl-c; amphid phasmid PDE axons abnormal; dorsal extensions of DD and VD neurons frequently grow in abnormal directions often fail to connect to dorsal nerve cord. ES3 ME0. NA1.
			[C.elegansII] e911pdi : inactive, tends to curl, dumpyish; Egl-c; amphid, phasmid, PDE, PVP, other axons abnormal; dorsal extensions of DD and VD neurons frequently grow in abnormal directions, often fail to connect to dorsal nervecord. Defects in axonal elongation and fasciculation along nerve cords. ES3 ME0. NA1. Cloned: 1.8 kb transcripts, encode predicted 385 or 376 aa novel proteins. Epitope-tagged UNC-76 detected in axons. [Hedgecock et al. 1985; McIntire et al. 1992; MT]
		Strain	WBStrain00022737
			WBStrain00022738
			WBStrain00026576
			WBStrain00027000
			WBStrain00027071
			WBStrain00027209
			WBStrain00027248
			WBStrain00027249
			WBStrain00027258
			WBStrain00027273
			WBStrain00027369
			WBStrain00027374
			WBStrain00027383
			WBStrain00028842
			WBStrain00029116
			WBStrain00029186
			WBStrain00029552
			WBStrain00034370
			WBStrain00034440
			WBStrain00035101
			WBStrain00035102
			WBStrain00035103
			WBStrain00035104
			WBStrain00035106
			WBStrain00035110
			WBStrain00040214
			WBStrain00000373
			WBStrain00000826
			WBStrain00003933
			WBStrain00004367
			WBStrain00005195
			WBStrain00005198
			WBStrain00005199
			WBStrain00005507
			WBStrain00005521
			WBStrain00006215
			WBStrain00006180
			WBStrain00007143
			WBStrain00008485
			WBStrain00008487
			WBStrain00008488
			WBStrain00008489
			WBStrain00008492
			WBStrain00008493
			WBStrain00008504
			WBStrain00008505
			WBStrain00008469
			WBStrain00008470
			WBStrain00008482
			WBStrain00008606
			WBStrain00047716
			WBStrain00047717
			WBStrain00051503
			WBStrain00051502
		RNASeq_FPKM (74)
		GO_annotation (22)
		Ortholog	WBGene00070400	Caenorhabditis remanei	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00032677	Caenorhabditis briggsae	From_analysis	OrthoMCL
						Inparanoid_8
						WormBase-Compara
			WBGene00144100	Caenorhabditis brenneri	From_analysis	OMA
						TreeFam
						Inparanoid_8
						WormBase-Compara
			WBGene00120319	Caenorhabditis japonica	From_analysis	Inparanoid_8
						WormBase-Compara
			WBGene00222154	Brugia malayi	From_analysis	WormBase-Compara
			CBOVI.g235	Caenorhabditis bovis	From_analysis	WormBase-Compara
			CSP21.g453	Caenorhabditis parvicauda	From_analysis	WormBase-Compara
			CSP26.g20596	Caenorhabditis zanzibari	From_analysis	WormBase-Compara
			CSP28.g18473	Caenorhabditis panamensis	From_analysis	WormBase-Compara
			CSP29.g17830	Caenorhabditis becei	From_analysis	WormBase-Compara
			CSP31.g22538	Caenorhabditis uteleia	From_analysis	WormBase-Compara
			CSP32.g11807	Caenorhabditis sulstoni	From_analysis	WormBase-Compara
			CSP38.g7543	Caenorhabditis quiockensis	From_analysis	WormBase-Compara
			CSP39.g23855	Caenorhabditis waitukubuli	From_analysis	WormBase-Compara
			CSP40.g3996	Caenorhabditis tribulationis	From_analysis	WormBase-Compara
			Cang_2012_03_13_00606.g12708	Caenorhabditis angaria	From_analysis	WormBase-Compara
			Cni-unc-76	Caenorhabditis nigoni	From_analysis	WormBase-Compara
			Csp11.Scaffold629.g15843	Caenorhabditis tropicalis	From_analysis	WormBase-Compara
			Csp5_scaffold_00006.g439	Caenorhabditis sinica	From_analysis	WormBase-Compara
			FL83_09752	Caenorhabditis latens	From_analysis	WormBase-Compara
			GCK72_017361	Caenorhabditis remanei	From_analysis	WormBase-Compara
			OTIPU.nOt.2.0.1.g05298	Oscheius tipulae	From_analysis	WormBase-Compara
			Pan_g13539	Panagrellus redivivus	From_analysis	WormBase-Compara
			Sp34_50267110	Caenorhabditis inopinata	From_analysis	WormBase-Compara
			chrV_pilon.g16687	Caenorhabditis elegans	From_analysis	WormBase-Compara
			WBGene00243520	Onchocerca volvulus	From_analysis	WormBase-Compara
			WBGene00108551	Pristionchus pacificus	From_analysis	WormBase-Compara
			WBGene00257276	Strongyloides ratti	From_analysis	WormBase-Compara
			WBGene00284969	Trichuris muris	From_analysis	WormBase-Compara
			FB:FBgn0040395	Drosophila melanogaster	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-040426-2723	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-041014-259	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			ZFIN:ZDB-GENE-110411-17	Danio rerio	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			HGNC:3660	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						SonicParanoid
			HGNC:3659	Homo sapiens	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			MGI:2675856	Mus musculus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			MGI:2670976	Mus musculus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:619708	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
			RGD:619709	Rattus norvegicus	From_analysis	EnsEMBL-Compara
						Hieranoid
						Inparanoid
						OMA
						OrthoFinder
						OrthoInspector
						Panther
						PhylomeDB
						SonicParanoid
		Structured_description	Concise_description	unc-76 encodes a predicted coiled-coil protein that belongs to the FEZ (fasciculation and elongation protein; zygin/zeta-1) family of proteins; UNC-76 activity is required for normal axonal outgrowth and fasciculation and hence, normal locomotion; UNC-76 expression begins during embryogenesis and is present in all axons throughout development; UNC-76 localizes to both axons and cell bodies.	Paper_evidence	WBPaper00002751
					Curator_confirmed	WBPerson1843
					Date_last_updated	31 May 2006 00:00:00
			Automated_description	Enables syntaxin binding activity. Involved in anterograde axonal protein transport; axonal fasciculation; and regulation of cellular component organization. Located in axon; neuronal cell body; and perinuclear region of cytoplasm. Expressed in neurons and somatic nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human FEZ1 (fasciculation and elongation protein zeta 1).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:5419	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:3659)
	Molecular_info	Corresponding_CDS	C01G10.11a
			C01G10.11b
			C01G10.11c
			C01G10.11d
			C01G10.11e
			C01G10.11f
		Corresponding_CDS_history	C01G10.11a:wp151
			C01G10.11b:wp151
		Corresponding_transcript	C01G10.11a.1
			C01G10.11b.1
			C01G10.11c.1
			C01G10.11d.1
			C01G10.11e.1
			C01G10.11f.1
		Other_sequence (20)
		Associated_feature (21)
	Experimental_info	RNAi_result	WBRNAi00089749	Inferred_automatically	RNAi_primary
			WBRNAi00027631	Inferred_automatically	RNAi_primary
			WBRNAi00009926	Inferred_automatically	RNAi_primary
			WBRNAi00089948	Inferred_automatically	RNAi_primary
			WBRNAi00039322	Inferred_automatically	RNAi_primary
			WBRNAi00086127	Inferred_automatically	RNAi_primary
			WBRNAi00090266	Inferred_automatically	RNAi_primary
			WBRNAi00090108	Inferred_automatically	RNAi_primary
		Expr_pattern	Expr1621
			Expr1019687
			Expr1032875
			Expr1143433
			Expr2017905
			Expr2036041
		Drives_construct	WBCnstr00001401
			WBCnstr00034141
		Construct_product (15)
		Antibody	WBAntibody00000143
		Microarray_results (40)
		Expression_cluster (180)
		Interaction (37)
	Map_info	Map	V	Position	7.32052	Error	0.012665
		Well_ordered
		Positive	Positive_clone	C01G10	Inferred_automatically	From sequence, transcript, pseudogene data
				C08C1	Inferred_automatically	From sequence, transcript, pseudogene data
		Negative	Outside_rearr	nDf31
				ozDf1
		Mapping_data	2_point (15)
			Multi_point (103)
			Pos_neg_data	4288
				4289
				4290
				4304
				8977
		Landmark_gene
	Reference (130)
	Method	Gene