WormBase Tree Display for Gene: WBGene00006815
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WBGene00006815 | SMap | S_parent | Sequence | W01A11 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | unc | ||||||
Reference_allele | WBVar00143983 | ||||||
Allele (315) | |||||||
Legacy_information | e1408ts : reverse kinker as adult variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable some can mate at 25x all can mate at 15x. ES3 ME3 (15x). NA11 (n331amber ts; e1409amber ts (suppressible only for hyp-7 defect)). | ||||||
See also e1408, e1409, n159, n1216, n1217, n1218 | |||||||
[C.elegansII] e1408ts : reverse kinker as adult, variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect,non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable, some can mate at 25C, all can mate at 15C. ES3 ME3 (15C). NA11: n331amb,ts, e1409amb,ts (suppressible only for hyp-7 defect), n159, n1218 etc. [Sulston and Horvitz 1981; MH; MT] | |||||||
Strain | WBStrain00026512 | ||||||
WBStrain00037609 | |||||||
WBStrain00037683 | |||||||
WBStrain00004325 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (27) | |||||||
Ortholog (26) | |||||||
Structured_description | Concise_description | unc-83 encodes a KASH domain-containing transmembrane protein; during development, UNC-83 is required for nuclear migrations in P cells, hyp7 hypodermal precursors, and intestinal cells and thus, for ventral nerve cord development, locomotion, and vulval formation; specifically, UNC-83 functions to recruit kinesin and dynein motor complexes to the nuclear envelope to regulate the directionality and extent of nuclear migrations; UNC-83 localizes to the outer nuclear membrane and its localization is dependent upon the SUN domain of UNC-84, an inner nuclear membrane protein with which it interacts in vitro; UNC-83 and UNC-84 are thus proposed to link the nuclear lamina with the cytoskeleton to properly effect nuclear migrations. | Paper_evidence | WBPaper00000496 | |||
WBPaper00003628 | |||||||
WBPaper00005053 | |||||||
WBPaper00005172 | |||||||
WBPaper00027107 | |||||||
WBPaper00035598 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 23 Apr 2010 00:00:00 | ||||||
Automated_description | Enables dynein light chain binding activity. Involved in several processes, including cellular localization; egg-laying behavior; and vulval development. Located in nuclear outer membrane. Expressed in several structures, including P1; P12; P2; P3; and P9. Used to study Emery-Dreifuss muscular dystrophy. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info (2) | |||||||
Models_disease_in_annotation | WBDOannot00000051 | ||||||
Molecular_info | Corresponding_CDS | W01A11.3a | |||||
W01A11.3b | |||||||
W01A11.3c | |||||||
Corresponding_CDS_history | W01A11.3:wp162 | ||||||
Corresponding_transcript | W01A11.3a.1 | ||||||
W01A11.3b.1 | |||||||
W01A11.3b.2 | |||||||
W01A11.3c.1 | |||||||
W01A11.3c.2 | |||||||
Other_sequence (22) | |||||||
Associated_feature (57) | |||||||
Experimental_info | RNAi_result | WBRNAi00090325 | Inferred_automatically | RNAi_primary | |||
WBRNAi00062672 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090007 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00054484 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00065283 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00054483 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089756 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00090166 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00062671 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00019442 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram318 | ||||||
Expr1789 | |||||||
Expr6810 | |||||||
Expr13170 | |||||||
Expr1023585 | |||||||
Expr1032880 | |||||||
Expr1158032 | |||||||
Expr2017912 | |||||||
Expr2036048 | |||||||
Drives_construct | WBCnstr00002621 | ||||||
Antibody | WBAntibody00000447 | ||||||
WBAntibody00002169 | |||||||
Microarray_results (31) | |||||||
Expression_cluster (171) | |||||||
Interaction (107) | |||||||
Map_info | Map | V | Position | -0.105154 | Error | 0.00884 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDf32 | |||||
nDf1 | |||||||
nDf18 | |||||||
nDf33 | |||||||
Positive_clone | W01A11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||
Mapping_data | 2_point | 311 | |||||
Multi_point | 141 | ||||||
142 | |||||||
653 | |||||||
657 | |||||||
658 | |||||||
5590 | |||||||
Pos_neg_data | 843 | ||||||
1735 | |||||||
1748 | |||||||
6813 | |||||||
6814 | |||||||
Reference (75) | |||||||
Method | Gene |