WormBase Tree Display for Gene: WBGene00006815
expand all nodes | collapse all nodes | view schema
| WBGene00006815 | SMap | S_parent | Sequence | W01A11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-83 | Person_evidence | WBPerson261 | |||||
| Sequence_name | W01A11.3 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | CeGrip | ||||||||
| CELE_W01A11.3 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | unc-83 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00006815 | |||||
| WormFlux | gene | WBGene00006815 | |||||||
| OMIM | disease | 610743 | |||||||
| 612998 | |||||||||
| NDB | locus_tag | CELE_W01A11.3 | |||||||
| NCBI | gene | 179033 | |||||||
| RefSeq | protein | NM_001392533.1 | |||||||
| NM_001392532.1 | |||||||||
| NM_001083280.3 | |||||||||
| SwissProt | UniProtAcc | Q23064 | |||||||
| TREEFAM | TREEFAM_ID | TF352677 | |||||||
| TrEMBL | UniProtAcc | Q0PDL1 | |||||||
| G8JYF1 | |||||||||
| UniProt_GCRP | UniProtAcc | Q23064 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143983 | ||||||||
| Allele (315) | |||||||||
| Legacy_information | e1408ts : reverse kinker as adult variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable some can mate at 25x all can mate at 15x. ES3 ME3 (15x). NA11 (n331amber ts; e1409amber ts (suppressible only for hyp-7 defect)). | ||||||||
| See also e1408, e1409, n159, n1216, n1217, n1218 | |||||||||
| [C.elegansII] e1408ts : reverse kinker as adult, variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect,non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable, some can mate at 25C, all can mate at 15C. ES3 ME3 (15C). NA11: n331amb,ts, e1409amb,ts (suppressible only for hyp-7 defect), n159, n1218 etc. [Sulston and Horvitz 1981; MH; MT] | |||||||||
| Strain | WBStrain00026512 | ||||||||
| WBStrain00037609 | |||||||||
| WBStrain00037683 | |||||||||
| WBStrain00004325 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (26) | |||||||||
| Structured_description | Concise_description | unc-83 encodes a KASH domain-containing transmembrane protein; during development, UNC-83 is required for nuclear migrations in P cells, hyp7 hypodermal precursors, and intestinal cells and thus, for ventral nerve cord development, locomotion, and vulval formation; specifically, UNC-83 functions to recruit kinesin and dynein motor complexes to the nuclear envelope to regulate the directionality and extent of nuclear migrations; UNC-83 localizes to the outer nuclear membrane and its localization is dependent upon the SUN domain of UNC-84, an inner nuclear membrane protein with which it interacts in vitro; UNC-83 and UNC-84 are thus proposed to link the nuclear lamina with the cytoskeleton to properly effect nuclear migrations. | Paper_evidence | WBPaper00000496 | |||||
| WBPaper00003628 | |||||||||
| WBPaper00005053 | |||||||||
| WBPaper00005172 | |||||||||
| WBPaper00027107 | |||||||||
| WBPaper00035598 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 23 Apr 2010 00:00:00 | ||||||||
| Automated_description | Enables dynein light chain binding activity. Involved in several processes, including cellular localization; egg-laying behavior; and vulval development. Located in nuclear outer membrane. Expressed in several structures, including P1; P12; P2; P3; and P9. Used to study Emery-Dreifuss muscular dystrophy. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info (2) | |||||||||
| Models_disease_in_annotation | WBDOannot00000051 | ||||||||
| Molecular_info | Corresponding_CDS | W01A11.3a | |||||||
| W01A11.3b | |||||||||
| W01A11.3c | |||||||||
| Corresponding_CDS_history | W01A11.3:wp162 | ||||||||
| Corresponding_transcript | W01A11.3a.1 | ||||||||
| W01A11.3b.1 | |||||||||
| W01A11.3b.2 | |||||||||
| W01A11.3c.1 | |||||||||
| W01A11.3c.2 | |||||||||
| Other_sequence (22) | |||||||||
| Associated_feature (57) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00090325 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00062672 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090007 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054484 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065283 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054483 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089756 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090166 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062671 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019442 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram318 | ||||||||
| Expr1789 | |||||||||
| Expr6810 | |||||||||
| Expr13170 | |||||||||
| Expr1023585 | |||||||||
| Expr1032880 | |||||||||
| Expr1158032 | |||||||||
| Expr2017912 | |||||||||
| Expr2036048 | |||||||||
| Drives_construct | WBCnstr00002621 | ||||||||
| Antibody | WBAntibody00000447 | ||||||||
| WBAntibody00002169 | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (171) | |||||||||
| Interaction | WBInteraction000002613 | ||||||||
| WBInteraction000002614 | |||||||||
| WBInteraction000003952 | |||||||||
| WBInteraction000028748 | |||||||||
| WBInteraction000031053 | |||||||||
| WBInteraction000031906 | |||||||||
| WBInteraction000126432 | |||||||||
| WBInteraction000126692 | |||||||||
| WBInteraction000144292 | |||||||||
| WBInteraction000144293 | |||||||||
| WBInteraction000161337 | |||||||||
| WBInteraction000165173 | |||||||||
| WBInteraction000165939 | |||||||||
| WBInteraction000166424 | |||||||||
| WBInteraction000182876 | |||||||||
| WBInteraction000185264 | |||||||||
| WBInteraction000185267 | |||||||||
| WBInteraction000188297 | |||||||||
| WBInteraction000202386 | |||||||||
| WBInteraction000211593 | |||||||||
| WBInteraction000222083 | |||||||||
| WBInteraction000229496 | |||||||||
| WBInteraction000233912 | |||||||||
| WBInteraction000233921 | |||||||||
| WBInteraction000233963 | |||||||||
| WBInteraction000250996 | |||||||||
| WBInteraction000252988 | |||||||||
| WBInteraction000264341 | |||||||||
| WBInteraction000275759 | |||||||||
| WBInteraction000275951 | |||||||||
| WBInteraction000287764 | |||||||||
| WBInteraction000301647 | |||||||||
| WBInteraction000308332 | |||||||||
| WBInteraction000329195 | |||||||||
| WBInteraction000336924 | |||||||||
| WBInteraction000339263 | |||||||||
| WBInteraction000341901 | |||||||||
| WBInteraction000352179 | |||||||||
| WBInteraction000355021 | |||||||||
| WBInteraction000365229 | |||||||||
| WBInteraction000382071 | |||||||||
| WBInteraction000388915 | |||||||||
| WBInteraction000390661 | |||||||||
| WBInteraction000391999 | |||||||||
| WBInteraction000393801 | |||||||||
| WBInteraction000403128 | |||||||||
| WBInteraction000404537 | |||||||||
| WBInteraction000405253 | |||||||||
| WBInteraction000417689 | |||||||||
| WBInteraction000423099 | |||||||||
| WBInteraction000424086 | |||||||||
| WBInteraction000425123 | |||||||||
| WBInteraction000429033 | |||||||||
| WBInteraction000429511 | |||||||||
| WBInteraction000429717 | |||||||||
| WBInteraction000429922 | |||||||||
| WBInteraction000437649 | |||||||||
| WBInteraction000442993 | |||||||||
| WBInteraction000453076 | |||||||||
| WBInteraction000453645 | |||||||||
| WBInteraction000460696 | |||||||||
| WBInteraction000466210 | |||||||||
| WBInteraction000473386 | |||||||||
| WBInteraction000522807 | |||||||||
| WBInteraction000540196 | |||||||||
| WBInteraction000540334 | |||||||||
| WBInteraction000543091 | |||||||||
| WBInteraction000543126 | |||||||||
| WBInteraction000543127 | |||||||||
| WBInteraction000543128 | |||||||||
| WBInteraction000543129 | |||||||||
| WBInteraction000543130 | |||||||||
| WBInteraction000543131 | |||||||||
| WBInteraction000543132 | |||||||||
| WBInteraction000543133 | |||||||||
| WBInteraction000543134 | |||||||||
| WBInteraction000543135 | |||||||||
| WBInteraction000543136 | |||||||||
| WBInteraction000543137 | |||||||||
| WBInteraction000543138 | |||||||||
| WBInteraction000543139 | |||||||||
| WBInteraction000543140 | |||||||||
| WBInteraction000543141 | |||||||||
| WBInteraction000543142 | |||||||||
| WBInteraction000543143 | |||||||||
| WBInteraction000543144 | |||||||||
| WBInteraction000543145 | |||||||||
| WBInteraction000543146 | |||||||||
| WBInteraction000543147 | |||||||||
| WBInteraction000543148 | |||||||||
| WBInteraction000543149 | |||||||||
| WBInteraction000543150 | |||||||||
| WBInteraction000543151 | |||||||||
| WBInteraction000543152 | |||||||||
| WBInteraction000543153 | |||||||||
| WBInteraction000543154 | |||||||||
| WBInteraction000543155 | |||||||||
| WBInteraction000543156 | |||||||||
| WBInteraction000543157 | |||||||||
| WBInteraction000543158 | |||||||||
| WBInteraction000555681 | |||||||||
| WBInteraction000556273 | |||||||||
| WBInteraction000556590 | |||||||||
| WBInteraction000556591 | |||||||||
| WBInteraction000556813 | |||||||||
| WBInteraction000557547 | |||||||||
| WBInteraction000557548 | |||||||||
| Map_info | Map | V | Position | -0.105154 | Error | 0.00884 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf32 | |||||||
| nDf1 | |||||||||
| nDf18 | |||||||||
| nDf33 | |||||||||
| Positive_clone | W01A11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 311 | |||||||
| Multi_point | 141 | ||||||||
| 142 | |||||||||
| 653 | |||||||||
| 657 | |||||||||
| 658 | |||||||||
| 5590 | |||||||||
| Pos_neg_data | 843 | ||||||||
| 1735 | |||||||||
| 1748 | |||||||||
| 6813 | |||||||||
| 6814 | |||||||||
| Reference (75) | |||||||||
| Method | Gene |
