WormBase Tree Display for Gene: WBGene00006815
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| WBGene00006815 | SMap | S_parent | Sequence | W01A11 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-83 | Person_evidence | WBPerson261 | |||||
| Sequence_name | W01A11.3 | ||||||||
| Molecular_name (11) | |||||||||
| Other_name | CeGrip | ||||||||
| CELE_W01A11.3 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | unc-83 | ||||||||
| DB_info | Database | WormQTL | gene | WBGene00006815 | |||||
| WormFlux | gene | WBGene00006815 | |||||||
| OMIM | disease | 610743 | |||||||
| 612998 | |||||||||
| NDB | locus_tag | CELE_W01A11.3 | |||||||
| NCBI | gene | 179033 | |||||||
| RefSeq | protein | NM_001392533.1 | |||||||
| NM_001392532.1 | |||||||||
| NM_001083280.3 | |||||||||
| SwissProt | UniProtAcc | Q23064 | |||||||
| TREEFAM | TREEFAM_ID | TF352677 | |||||||
| TrEMBL | UniProtAcc | Q0PDL1 | |||||||
| G8JYF1 | |||||||||
| UniProt_GCRP | UniProtAcc | Q23064 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143983 | ||||||||
| Allele (315) | |||||||||
| Legacy_information | e1408ts : reverse kinker as adult variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable some can mate at 25x all can mate at 15x. ES3 ME3 (15x). NA11 (n331amber ts; e1409amber ts (suppressible only for hyp-7 defect)). | ||||||||
| See also e1408, e1409, n159, n1216, n1217, n1218 | |||||||||
| [C.elegansII] e1408ts : reverse kinker as adult, variably Egl; L1 moves well; variable failures in postembryonic migration of Pn nuclei into ventral cord and (some alleles) embryonic migrations of hyp-7 hypodermal nuclei; all alleles are ts for Pn defect,non-ts for hyp-7 defect; unmigrated Pn nuclei mostly fail to divide; adult male phenotype variable, some can mate at 25C, all can mate at 15C. ES3 ME3 (15C). NA11: n331amb,ts, e1409amb,ts (suppressible only for hyp-7 defect), n159, n1218 etc. [Sulston and Horvitz 1981; MH; MT] | |||||||||
| Strain | WBStrain00026512 | ||||||||
| WBStrain00037609 | |||||||||
| WBStrain00037683 | |||||||||
| WBStrain00004325 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (27) | |||||||||
| Ortholog (26) | |||||||||
| Structured_description | Concise_description | unc-83 encodes a KASH domain-containing transmembrane protein; during development, UNC-83 is required for nuclear migrations in P cells, hyp7 hypodermal precursors, and intestinal cells and thus, for ventral nerve cord development, locomotion, and vulval formation; specifically, UNC-83 functions to recruit kinesin and dynein motor complexes to the nuclear envelope to regulate the directionality and extent of nuclear migrations; UNC-83 localizes to the outer nuclear membrane and its localization is dependent upon the SUN domain of UNC-84, an inner nuclear membrane protein with which it interacts in vitro; UNC-83 and UNC-84 are thus proposed to link the nuclear lamina with the cytoskeleton to properly effect nuclear migrations. | Paper_evidence | WBPaper00000496 | |||||
| WBPaper00003628 | |||||||||
| WBPaper00005053 | |||||||||
| WBPaper00005172 | |||||||||
| WBPaper00027107 | |||||||||
| WBPaper00035598 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 23 Apr 2010 00:00:00 | ||||||||
| Automated_description | Enables dynein light chain binding activity. Involved in several processes, including cellular localization; egg-laying behavior; and vulval development. Located in nuclear outer membrane. Expressed in several structures, including P1; P12; P2; P3; and P9. Used to study Emery-Dreifuss muscular dystrophy. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info (2) | |||||||||
| Models_disease_in_annotation | WBDOannot00000051 | ||||||||
| Molecular_info | Corresponding_CDS | W01A11.3a | |||||||
| W01A11.3b | |||||||||
| W01A11.3c | |||||||||
| Corresponding_CDS_history | W01A11.3:wp162 | ||||||||
| Corresponding_transcript | W01A11.3a.1 | ||||||||
| W01A11.3b.1 | |||||||||
| W01A11.3b.2 | |||||||||
| W01A11.3c.1 | |||||||||
| W01A11.3c.2 | |||||||||
| Other_sequence (22) | |||||||||
| Associated_feature (57) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00090325 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00062672 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090007 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054484 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00065283 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00054483 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089756 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00090166 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00062671 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00019442 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Chronogram318 | ||||||||
| Expr1789 | |||||||||
| Expr6810 | |||||||||
| Expr13170 | |||||||||
| Expr1023585 | |||||||||
| Expr1032880 | |||||||||
| Expr1158032 | |||||||||
| Expr2017912 | |||||||||
| Expr2036048 | |||||||||
| Drives_construct | WBCnstr00002621 | ||||||||
| Antibody | WBAntibody00000447 | ||||||||
| WBAntibody00002169 | |||||||||
| Microarray_results (31) | |||||||||
| Expression_cluster (171) | |||||||||
| Interaction (107) | |||||||||
| Map_info | Map | V | Position | -0.105154 | Error | 0.00884 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf32 | |||||||
| nDf1 | |||||||||
| nDf18 | |||||||||
| nDf33 | |||||||||
| Positive_clone | W01A11 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | 2_point | 311 | |||||||
| Multi_point | 141 | ||||||||
| 142 | |||||||||
| 653 | |||||||||
| 657 | |||||||||
| 658 | |||||||||
| 5590 | |||||||||
| Pos_neg_data | 843 | ||||||||
| 1735 | |||||||||
| 1748 | |||||||||
| 6813 | |||||||||
| 6814 | |||||||||
| Reference | WBPaper00000496 | ||||||||
| WBPaper00000500 | |||||||||
| WBPaper00000608 | |||||||||
| WBPaper00000672 | |||||||||
| WBPaper00002837 | |||||||||
| WBPaper00003628 | |||||||||
| WBPaper00004408 | |||||||||
| WBPaper00005041 | |||||||||
| WBPaper00005053 | |||||||||
| WBPaper00005172 | |||||||||
| WBPaper00012419 | |||||||||
| WBPaper00013667 | |||||||||
| WBPaper00013792 | |||||||||
| WBPaper00014076 | |||||||||
| WBPaper00014791 | |||||||||
| WBPaper00015175 | |||||||||
| WBPaper00015279 | |||||||||
| WBPaper00016044 | |||||||||
| WBPaper00017147 | |||||||||
| WBPaper00017310 | |||||||||
| WBPaper00017789 | |||||||||
| WBPaper00017883 | |||||||||
| WBPaper00020919 | |||||||||
| WBPaper00022135 | |||||||||
| WBPaper00022192 | |||||||||
| WBPaper00022306 | |||||||||
| WBPaper00022522 | |||||||||
| WBPaper00023414 | |||||||||
| WBPaper00023676 | |||||||||
| WBPaper00024052 | |||||||||
| WBPaper00024053 | |||||||||
| WBPaper00026102 | |||||||||
| WBPaper00026191 | |||||||||
| WBPaper00027107 | |||||||||
| WBPaper00027235 | |||||||||
| WBPaper00027801 | |||||||||
| WBPaper00027830 | |||||||||
| WBPaper00030596 | |||||||||
| WBPaper00033544 | |||||||||
| WBPaper00033699 | |||||||||
| WBPaper00034728 | |||||||||
| WBPaper00034804 | |||||||||
| WBPaper00035020 | |||||||||
| WBPaper00035039 | |||||||||
| WBPaper00035598 | |||||||||
| WBPaper00036543 | |||||||||
| WBPaper00036889 | |||||||||
| WBPaper00037662 | |||||||||
| WBPaper00038236 | |||||||||
| WBPaper00038630 | |||||||||
| WBPaper00038662 | |||||||||
| WBPaper00039986 | |||||||||
| WBPaper00040127 | |||||||||
| WBPaper00042755 | |||||||||
| WBPaper00043397 | |||||||||
| WBPaper00043419 | |||||||||
| WBPaper00043508 | |||||||||
| WBPaper00045548 | |||||||||
| WBPaper00047337 | |||||||||
| WBPaper00047338 | |||||||||
| WBPaper00047349 | |||||||||
| WBPaper00050286 | |||||||||
| WBPaper00051949 | |||||||||
| WBPaper00051989 | |||||||||
| WBPaper00052007 | |||||||||
| WBPaper00054441 | |||||||||
| WBPaper00056587 | |||||||||
| WBPaper00057743 | |||||||||
| WBPaper00057744 | |||||||||
| WBPaper00059037 | |||||||||
| WBPaper00061990 | |||||||||
| WBPaper00063093 | |||||||||
| WBPaper00063150 | |||||||||
| WBPaper00064576 | |||||||||
| WBPaper00064898 | |||||||||
| Method | Gene |
