WormBase Tree Display for Gene: WBGene00006827

WBGene00006827 SMap: S_parent: Sequence: F08C6
  Identity: Version: 2
    Name: CGC_name: unc-98 Person_evidence: WBPerson261
      Sequence_name: F08C6.7
      Molecular_name: F08C6.7
        F08C6.7.1
        CE31900
      Other_name: CELE_F08C6.7 Accession_evidence: NDB BX284606
      Public_name: unc-98
    DB_info: Database: AceView gene XI190
        WormQTL gene WBGene00006827
        WormFlux gene WBGene00006827
        NDB locus_tag CELE_F08C6.7
        Panther gene CAEEL|WormBase=WBGene00006827|UniProtKB=Q19203
          family PTHR24409
        NCBI gene 181020
        RefSeq protein NM_076883.8
        SwissProt UniProtAcc Q19203
        TREEFAM TREEFAM_ID TF318243
        UniProt_GCRP UniProtAcc Q19203
    Species: Caenorhabditis elegans
    History (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00248848
    Allele (65)
    Legacy_information: su130 : slow somewhat Egl; abnormal muscle birefringence and ultrastructure collections of thin filaments poorly organized A and I bands. ES2 ME1. NA1.
      [C.elegansII] su130 : slow somewhat Egl; abnormal muscle birefringence and ultrastructure, collections of thin filaments, poorly organized A and I bands; variable defects in neuroanatomy. ES2 ME1. NA1. [Zengel and Epstein 1980; Siddiqui and Culotti 1991;HE; SQ]
    Strain: WBStrain00035294
      WBStrain00035295
      WBStrain00035296
      WBStrain00007704
      WBStrain00008391
      WBStrain00029994
    RNASeq_FPKM (74)
    GO_annotation (29)
    Ortholog (28)
    Paralog: WBGene00005008 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00011924 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00011925 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-98 encodes a protein with four C2H2 zinc fingers and several possible nuclear localization and export sequences; UNC-98 is required for normal mobility, M-line, and dense body (Z-disk analog) structures; UNC-98 binds the C-terminal portion of myosin heavy chain, as well as a number of proteins that localize to the base of dense bodies and M lines, including UNC-97/PINCH, suggesting that in vivo UNC-98 functions to link myosin thick filaments to an integrin-associated protein complex at the muscle cell membrane; UNC-98 also interacts with UNC-96, UNC-15/paramyosin, the unconventional myosin HUM-6 and the zinc-finger protein MEP-1; UNC-98 localizes to M-lines, muscle cell nuclei, and perhaps also to dense bodies. Paper_evidence: WBPaper00000488
            WBPaper00005938
            WBPaper00027703
            WBPaper00028888
            WBPaper00031500
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 28 Mar 2008 00:00:00
      Automated_description: Enables cytoskeletal protein binding activity. Involved in several processes, including locomotory behavior; myofibril assembly; and post-embryonic body morphogenesis. Located in M band and nucleus. Expressed in anal depressor muscle; body wall musculature; head muscle; and vulval muscle. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F08C6.7
    Corresponding_CDS_history: F08C6.7:wp86
      F08C6.7a:wp264
      F08C6.7b:wp264
    Corresponding_transcript: F08C6.7.1
    Other_sequence (47)
    Associated_feature: WBsf654148
      WBsf978790
      WBsf1023267
      WBsf237597
      WBsf237598
    Transcription_factor: WBTranscriptionFactor000514
  Experimental_info: RNAi_result (15)
    Expr_pattern (13)
    Drives_construct: WBCnstr00001104
      WBCnstr00001105
      WBCnstr00001106
      WBCnstr00006704
      WBCnstr00010860
      WBCnstr00012642
      WBCnstr00034132
    Construct_product: WBCnstr00006704
      WBCnstr00010860
      WBCnstr00015365
      WBCnstr00021932
      WBCnstr00034132
    Antibody: WBAntibody00000647
      WBAntibody00001195
    Microarray_results (18)
    Expression_cluster (123)
    Interaction (93)
    WBProcess: WBbiopr:00000006
  Map_info: Map: X Position: -1.49623 Error: 0.009635
    Positive: Positive_clone: F08C6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 398
        399
      Multi_point: 5567
      Pos_neg_data: 1834
        1836
  Reference (36)
  Remark: Sequence connection based on AF515600 [020925 ck1]
  Method: Gene