WormBase Tree Display for Gene: WBGene00006830

WBGene00006830 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 2
    Name: CGC_name: unc-103 Person_evidence: WBPerson261
      Sequence_name: C30D11.1
      Molecular_name (57)
      Other_name: CELE_C30D11.1 Accession_evidence: NDB BX284603
      Public_name: unc-103
    DB_info: Database: WormQTL gene WBGene00006830
        WormFlux gene WBGene00006830
        NDB locus_tag CELE_C30D11.1
        Panther gene CAEEL|WormBase=WBGene00006830|UniProtKB=G5EFJ9
          family PTHR10217
        NCBI gene 175527
        RefSeq protein (19)
        SwissProt UniProtAcc G5EFJ9
        TrEMBL UniProtAcc A0A8D7ZGL5
            A0A8D7ZF36
            A0A8D7ZGA2
            A0A8D7ZEX1
            A0A8D7ZEY3
            A0A8D7ZEU0
            A0A8D8EJ82
            A0A8D7ZEP4
            A0A8D7ZGB1
        UniProt_GCRP UniProtAcc G5EFJ9
        OMIM gene 152427
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 20 Jun 2007 16:44:06 WBPerson1983 Event: Acquires_merge: WBGene00007815
      Acquires_merge: WBGene00007815
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (416)
    Legacy_information: Class 3 allele e1597sd : severe kinker little movement slight Egl; e1597/+ somewhat less severe kinker. ES3 ME0. NA2 (n500). Class 1 (loss-of-function) alleles : intragenic revertants of e1596 e.g. e1597n1212 wildtype phenotype.
      See also e1597, n500, n1211, n1212, n1213, n1214, n1215
      [Reiner D]] Mac-d (Muscle ACtivation-Defective)
      [C.elegansII] e1597sd : homozygote severe kinker, little movement; slight Egl; e1597/+ somewhat less severe kinker. Muscle activation defective(flaccid, long). Neomorphic (gf) allele.ES3 ME0. OA1 (gf): n500. Also intragenic revertants: e1597n1212spo(wildtype, probable null), e1597n1213, n500n1211 etc. OA5 (ird). [Park and Horvitz 1986a; JT; MT]
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (44)
    Paralog: WBGene00001171 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00000487 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000562 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000563 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006525 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006526 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022295 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-103 encodes an ether-a-go-go-related (ERG) K+ channel homolog, orthologous to human KCNH6 (OMIM:608168); UNC-103 regulates muscle activation in motility, egg-laying and male spicule protraction; UNC-103 is expressed highly in many neurons; gain-of-function unc-103 alleles can be uncoordinated, while loss-of-function alleles have a more subtle defect in copulatory spicule protraction. Paper_evidence: WBPaper00000914
            WBPaper00002305
            WBPaper00005799
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 09 Feb 2011 00:00:00
      Automated_description: Predicted to enable inward rectifier potassium channel activity. Involved in mating behavior and regulation of muscle contraction. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Expressed in body wall musculature; neurons; non-striated muscle; and in male. Used to study long QT syndrome. Human ortholog(s) of this gene implicated in long QT syndrome 2 and short QT syndrome. Is an ortholog of human KCNH2 (potassium voltage-gated channel subfamily H member 2) and KCNH7 (potassium voltage-gated channel subfamily H member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:2843
    Potential_model: DOID:0050793 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6251)
      DOID:0110645 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6251)
      DOID:2843 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6251)
  Models_disease_asserted: WBDOannot00000527
  Molecular_info: Corresponding_CDS (19)
    Corresponding_CDS_history: C30D11.1:wp52
    Corresponding_transcript (19)
    Other_sequence (14)
    Associated_feature (50)
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr2455
      Expr3095
      Expr3815
      Expr4896
      Expr10803
      Expr1012330
      Expr1032893
      Expr1145556
      Expr2017833
      Expr2035969
    Drives_construct (21)
    Construct_product (21)
    Microarray_results (42)
    Expression_cluster (137)
    Interaction: WBInteraction000000961
      WBInteraction000001233
      WBInteraction000002033
      WBInteraction000002034
      WBInteraction000002036
      WBInteraction000005141
      WBInteraction000005374
      WBInteraction000005437
      WBInteraction000005438
      WBInteraction000009182
      WBInteraction000009183
      WBInteraction000009527
      WBInteraction000009550
      WBInteraction000009781
      WBInteraction000029172
      WBInteraction000029306
      WBInteraction000050744
      WBInteraction000117807
      WBInteraction000126559
      WBInteraction000126967
      WBInteraction000142765
      WBInteraction000144697
      WBInteraction000156883
      WBInteraction000165843
      WBInteraction000166433
      WBInteraction000166434
      WBInteraction000166435
      WBInteraction000166436
      WBInteraction000171921
      WBInteraction000174017
      WBInteraction000193880
      WBInteraction000197629
      WBInteraction000201836
      WBInteraction000204303
      WBInteraction000210926
      WBInteraction000212074
      WBInteraction000215293
      WBInteraction000219997
      WBInteraction000234803
      WBInteraction000252589
      WBInteraction000259363
      WBInteraction000269514
      WBInteraction000281471
      WBInteraction000282615
      WBInteraction000283067
      WBInteraction000295245
      WBInteraction000296757
      WBInteraction000298346
      WBInteraction000301810
      WBInteraction000310502
      WBInteraction000310576
      WBInteraction000316812
      WBInteraction000316891
      WBInteraction000318625
      WBInteraction000322817
      WBInteraction000329242
      WBInteraction000331202
      WBInteraction000331626
      WBInteraction000336056
      WBInteraction000342535
      WBInteraction000342763
      WBInteraction000349806
      WBInteraction000355756
      WBInteraction000361040
      WBInteraction000369414
      WBInteraction000369418
      WBInteraction000369472
      WBInteraction000369708
      WBInteraction000372762
      WBInteraction000377637
      WBInteraction000378053
      WBInteraction000380137
      WBInteraction000385043
      WBInteraction000385044
      WBInteraction000392192
      WBInteraction000397202
      WBInteraction000401837
      WBInteraction000402777
      WBInteraction000407153
      WBInteraction000413678
      WBInteraction000415349
      WBInteraction000416271
      WBInteraction000430527
      WBInteraction000448706
      WBInteraction000463309
      WBInteraction000505188
      WBInteraction000505189
      WBInteraction000505191
      WBInteraction000505192
      WBInteraction000519686
      WBInteraction000542146
      WBInteraction000560650
    Anatomy_function: WBbtf0572
      WBbtf0573
      WBbtf0574
      WBbtf0575
  Map_info: Map: III Position: -3.78592 Error: 0.004728
    Well_ordered
    Positive: Positive_clone: C30D11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 862
        1079
        2799
        3603
        4091
        4458
  Reference: WBPaper00000608
    WBPaper00000914
    WBPaper00002305
    WBPaper00003765
    WBPaper00004406
    WBPaper00005799
    WBPaper00006103
    WBPaper00006402
    WBPaper00010339
    WBPaper00014942
    WBPaper00015071
    WBPaper00015306
    WBPaper00015374
    WBPaper00015440
    WBPaper00016989
    WBPaper00017178
    WBPaper00017225
    WBPaper00017356
    WBPaper00019178
    WBPaper00022012
    WBPaper00022410
    WBPaper00022655
    WBPaper00023932
    WBPaper00023933
    WBPaper00024082
    WBPaper00024345
    WBPaper00024447
    WBPaper00025521
    WBPaper00025745
    WBPaper00026425
    WBPaper00027020
    WBPaper00027249
    WBPaper00027624
    WBPaper00027720
    WBPaper00028126
    WBPaper00028127
    WBPaper00028141
    WBPaper00028146
    WBPaper00029029
    WBPaper00030175
    WBPaper00030191
    WBPaper00031038
    WBPaper00031105
    WBPaper00032000
    WBPaper00032386
    WBPaper00037198
    WBPaper00037199
    WBPaper00037314
    WBPaper00037366
    WBPaper00037370
    WBPaper00037371
    WBPaper00037374
    WBPaper00037916
    WBPaper00038246
    WBPaper00038491
    WBPaper00039032
    WBPaper00039250
    WBPaper00039378
    WBPaper00040284
    WBPaper00041908
    WBPaper00042470
    WBPaper00043390
    WBPaper00043908
    WBPaper00047806
    WBPaper00049295
    WBPaper00052590
    WBPaper00054777
    WBPaper00054909
    WBPaper00055090
    WBPaper00059520
    WBPaper00060850
    WBPaper00060853
    WBPaper00064886
  Remark: being swapped with mpk-1 at -4.05. was -3.93 [jah/sdm 5/99]
    klp-1 is the same gene as unc-103 and was therefore merged with this gene
  Method: Gene