WormBase Tree Display for Gene: WBGene00006830

WBGene00006830 SMap: S_parent: Sequence: CHROMOSOME_III
  Identity: Version: 2
    Name: CGC_name: unc-103 Person_evidence: WBPerson261
      Sequence_name: C30D11.1
      Molecular_name (57)
      Other_name: CELE_C30D11.1 Accession_evidence: NDB BX284603
      Public_name: unc-103
    DB_info: Database: WormQTL gene WBGene00006830
        WormFlux gene WBGene00006830
        NDB locus_tag CELE_C30D11.1
        Panther gene CAEEL|WormBase=WBGene00006830|UniProtKB=G5EFJ9
          family PTHR10217
        NCBI gene 175527
        RefSeq protein (19)
        SwissProt UniProtAcc G5EFJ9
        TrEMBL UniProtAcc A0A8D7ZGL5
            A0A8D7ZF36
            A0A8D7ZGA2
            A0A8D7ZEX1
            A0A8D7ZEY3
            A0A8D7ZEU0
            A0A8D8EJ82
            A0A8D7ZEP4
            A0A8D7ZGB1
        UniProt_GCRP UniProtAcc G5EFJ9
        OMIM gene 152427
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 20 Jun 2007 16:44:06 WBPerson1983 Event: Acquires_merge: WBGene00007815
      Acquires_merge: WBGene00007815
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele: WBVar00090037 Inferred_automatically: From strain object: CG289
          From strain object: CG490
          From strain object: CG499
          From strain object: CG500
          From strain object: CG625
          From strain object: CG640
          From strain object: MT2635
      WBVar00090035 Inferred_automatically: From strain object: MT2633
      WBVar00090038 Inferred_automatically: From strain object: MT2636
      WBVar00090039
      WBVar00090036
      WBVar00144138
      WBVar00144137
      WBVar00089558
      WBVar01479643
      WBVar00820103
      WBVar01479644
      WBVar00820104
      WBVar01479645
      WBVar00820105
      WBVar00820106
      WBVar01479646
      WBVar00820107
      WBVar01479647
      WBVar00820108
      WBVar01479648
      WBVar00820109
      WBVar01479649
      WBVar00275943
      WBVar00275944
      WBVar00820110
      WBVar01999553
      WBVar02015206
      WBVar00820111
      WBVar02015207
      WBVar00820112
      WBVar01827646
      WBVar00820113
      WBVar00820114
      WBVar00820115
      WBVar00820116
      WBVar00820117
      WBVar00820118
      WBVar01408454
      WBVar02157772
      WBVar00820119
      WBVar01785397
      WBVar00820120
      WBVar00820121
      WBVar00820122
      WBVar02053220
      WBVar00820123
      WBVar00820124
      WBVar00819941
      WBVar00820125
      WBVar00820126
      WBVar00819942
      WBVar00820127
      WBVar00819943
      WBVar00820128
      WBVar00819944
      WBVar00820129
      WBVar00819945
      WBVar00820130
      WBVar00819946
      WBVar00819947
      WBVar02010392
      WBVar00820131
      WBVar00819948
      WBVar00820132
      WBVar02073246
      WBVar00819949
      WBVar00820133
      WBVar00819950
      WBVar00820134
      WBVar00820135
      WBVar00819951
      WBVar00819952
      WBVar00819953
      WBVar00819954
      WBVar00819955
      WBVar00819956
      WBVar00819957
      WBVar01628431
      WBVar01628432
      WBVar00819958
      WBVar00819959
      WBVar00819960
      WBVar00819961
      WBVar00819962
      WBVar00819963
      WBVar00819964
      WBVar00819965
      WBVar00819966
      WBVar00249010
      WBVar00819967
      WBVar00819968
      WBVar00819969
      WBVar00819970
      WBVar00058926
      WBVar00819971
      WBVar00819972
      WBVar00819973
      WBVar00819974
      WBVar00058931
      WBVar00819975
      WBVar00819976
      WBVar02074210
      WBVar01473956
      WBVar01473957
      WBVar00819977
      WBVar01473958
      WBVar00819978
      WBVar00058941
      WBVar00819979
      WBVar00819980
      WBVar00819981
      WBVar00249028
      WBVar00058946
      WBVar00819982
      WBVar00395419
      WBVar00395420
      WBVar00142310
      WBVar00819983
      WBVar00249030
      WBVar00395421
      WBVar00819984
      WBVar00395422
      WBVar01262749
      WBVar00819985
      WBVar00058951
      WBVar00249031
      WBVar00395423
      WBVar00819986
      WBVar00395424
      WBVar00819987
      WBVar01262753
      WBVar00395425
      WBVar00819988
      WBVar01262754
      WBVar00819989
      WBVar01262755
      WBVar00395426
      WBVar00395427
      WBVar01903705
      WBVar02034119
      WBVar01262756
      WBVar00058961
      WBVar00819990
      WBVar01262757
      WBVar00395428
      WBVar02034120
      WBVar00819991
      WBVar01262758
      WBVar01490756
      WBVar02034121
      WBVar00819992
      WBVar00395429
      WBVar00395430
      WBVar00058966
      WBVar00819993
      WBVar00395431
      WBVar01656509
      WBVar00819994
      WBVar00395432
      WBVar00819995
      WBVar01644017
      WBVar01825487
      WBVar01644018
      WBVar00058971
      WBVar00395433
      WBVar00819996
      WBVar01893149
      WBVar01644019
      WBVar01578853
      WBVar00819997
      WBVar00395434
      WBVar00819998
      WBVar01893150
      WBVar00067859
      WBVar00395435
      WBVar00819999
      WBVar01893151
      WBVar00395436
      WBVar00058976
      WBVar00395437
      WBVar00820000
      WBVar00395438
      WBVar00820001
      WBVar00395439
      WBVar00820002
      WBVar00058981
      WBVar00089557
      WBVar00395440
      WBVar00820003
      WBVar00395441
      WBVar00820004
      WBVar00263783
      WBVar00395442
      WBVar00058986
      WBVar00820005
      WBVar00395443
      WBVar00820006
      WBVar00820007
      WBVar00395444
      WBVar00058991
      WBVar00820008
      WBVar00395445
      WBVar00820009
      WBVar00395446
      WBVar01541709
      WBVar00820010
      WBVar00395447
      WBVar00395448
      WBVar00820011
      WBVar00058996
      WBVar00820012
      WBVar00395449
      WBVar00820013
      WBVar00395450
      WBVar00059001
      WBVar00395451
      WBVar00820014
      WBVar00820015
      WBVar01952126
      WBVar00395452
      WBVar01952127
      WBVar00395453
      WBVar00820016
      WBVar00395454
      WBVar01952128
      WBVar00820017
      WBVar00059006
      WBVar00820018
      WBVar00395455
      WBVar00395456
      WBVar00820019
      WBVar00820020
      WBVar00395457
      WBVar00059011
      WBVar00395458
      WBVar00820021
      WBVar01496122
      WBVar00395459
      WBVar00820022
      WBVar00820023
      WBVar00059016
      WBVar00395460
      WBVar01962684
      WBVar00395461
      WBVar01962685
      WBVar00820024
      WBVar00820025
      WBVar00395462
      WBVar01962686
      WBVar00820026
      WBVar00395463
      WBVar00059021
      WBVar01962687
      WBVar01962688
      WBVar00395464
      WBVar00820027
      WBVar01962689
      WBVar00395465
      WBVar00820028
      WBVar00820029
      WBVar00395466
      WBVar01962690
      WBVar01962691
      WBVar00820030
      WBVar00395467
      WBVar00089642
      WBVar00820031
      WBVar00395468
      WBVar00089643
      WBVar01962692
      WBVar00395469
      WBVar01962693
      WBVar00820032
      WBVar00089644
      WBVar01962694
      WBVar01837423
      WBVar00820033
      WBVar00395470
      WBVar00395471
      WBVar01962695
      WBVar00820034
      WBVar01837424
      WBVar01962696
      WBVar00395472
      WBVar01837425
      WBVar00820035
      WBVar00820036
      WBVar00395473
      WBVar00820037
      WBVar00395474
      WBVar00820038
      WBVar00395475
      WBVar00395476
      WBVar00820039
      WBVar00563066
      WBVar00395477
      WBVar00563071
      WBVar00820040
      WBVar00395478
      WBVar00820041
      WBVar00395479
      WBVar00820042
      WBVar00820043
      WBVar02147798
      WBVar00395480
      WBVar00820044
      WBVar00395481
      WBVar00395482
      WBVar00820045
      WBVar00395483
      WBVar00820046
      WBVar00820047
      WBVar00820048
      WBVar01492836
      WBVar00820049
      WBVar00820050
      WBVar02117050
      WBVar00820051
      WBVar00820052
      WBVar00820053
      WBVar01938933
      WBVar00820054
      WBVar01445196
      WBVar01938934
      WBVar02003331
      WBVar01445197
      WBVar00820055
      WBVar01445199
      WBVar00820056
      WBVar01938935
      WBVar01445201
      WBVar00820057
      WBVar01445203
      WBVar00820058
      WBVar00099195
      WBVar01495975
      WBVar00820059
      WBVar00820060
      WBVar00051956
      WBVar00820061
      WBVar00820062
      WBVar00820063
      WBVar00051961
      WBVar00820064
      WBVar00820065
      WBVar00820066
      WBVar00820067
      WBVar00051966
      WBVar00820068
      WBVar01983883
      WBVar00820069
      WBVar00051971
      WBVar00820070
      WBVar00820071
      WBVar00820072
      WBVar01990061
      WBVar01488629
      WBVar00820073
      WBVar00051976
      WBVar02113576
      WBVar00820074
      WBVar00820075
      WBVar00820076
      WBVar00051981
      WBVar01606998
      WBVar00820077
      WBVar00820078
      WBVar01566292
      WBVar00820079
      WBVar00144136
      WBVar01566293
      WBVar00820080
      WBVar00820081
      WBVar01330306
      WBVar01566294
      WBVar00820082
      WBVar01566295
      WBVar00820083
      WBVar01566296
      WBVar01566297
      WBVar00820084
      WBVar00820085
      WBVar00820086
      WBVar00820087
      WBVar00820088
      WBVar00820089
      WBVar02144043
      WBVar00820090
      WBVar00820091
      WBVar00820092
      WBVar00820093
      WBVar02131839
      WBVar00820094
      WBVar01415997
      WBVar02131840
      WBVar01415998
      WBVar00820095
      WBVar02131841
      WBVar00820096
      WBVar02131842
      WBVar00820097
      WBVar02131843
      WBVar02131844
      WBVar00820098
      WBVar02131845
      WBVar01709954
      WBVar00820099
      WBVar00820100
      WBVar02131846
      WBVar01709955
      WBVar01709956
      WBVar01479641
      WBVar00820101
      WBVar01709957
      WBVar01479642
      WBVar00820102
    Legacy_information: Class 3 allele e1597sd : severe kinker little movement slight Egl; e1597/+ somewhat less severe kinker. ES3 ME0. NA2 (n500). Class 1 (loss-of-function) alleles : intragenic revertants of e1596 e.g. e1597n1212 wildtype phenotype.
      See also e1597, n500, n1211, n1212, n1213, n1214, n1215
      [Reiner D]] Mac-d (Muscle ACtivation-Defective)
      [C.elegansII] e1597sd : homozygote severe kinker, little movement; slight Egl; e1597/+ somewhat less severe kinker. Muscle activation defective(flaccid, long). Neomorphic (gf) allele.ES3 ME0. OA1 (gf): n500. Also intragenic revertants: e1597n1212spo(wildtype, probable null), e1597n1213, n500n1211 etc. OA5 (ird). [Park and Horvitz 1986a; JT; MT]
    Strain (13)
    RNASeq_FPKM (74)
    GO_annotation (22)
    Ortholog (44)
    Paralog: WBGene00001171 Caenorhabditis elegans From_analysis: TreeFam
            WormBase-Compara
      WBGene00000487 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000562 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00000563 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006525 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006526 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022295 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: unc-103 encodes an ether-a-go-go-related (ERG) K+ channel homolog, orthologous to human KCNH6 (OMIM:608168); UNC-103 regulates muscle activation in motility, egg-laying and male spicule protraction; UNC-103 is expressed highly in many neurons; gain-of-function unc-103 alleles can be uncoordinated, while loss-of-function alleles have a more subtle defect in copulatory spicule protraction. Paper_evidence: WBPaper00000914
            WBPaper00002305
            WBPaper00005799
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 09 Feb 2011 00:00:00
      Automated_description: Predicted to enable inward rectifier potassium channel activity. Involved in mating behavior and regulation of muscle contraction. Predicted to be located in plasma membrane. Predicted to be part of monoatomic ion channel complex. Expressed in body wall musculature; neurons; non-striated muscle; and in male. Used to study long QT syndrome. Human ortholog(s) of this gene implicated in long QT syndrome 2 and short QT syndrome. Is an ortholog of human KCNH2 (potassium voltage-gated channel subfamily H member 2) and KCNH7 (potassium voltage-gated channel subfamily H member 7). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:2843
    Potential_model (3)
  Models_disease_asserted: WBDOannot00000527
  Molecular_info: Corresponding_CDS (19)
    Corresponding_CDS_history: C30D11.1:wp52
    Corresponding_transcript (19)
    Other_sequence (14)
    Associated_feature (50)
  Experimental_info: RNAi_result (21)
    Expr_pattern: Expr2455
      Expr3095
      Expr3815
      Expr4896
      Expr10803
      Expr1012330
      Expr1032893
      Expr1145556
      Expr2017833
      Expr2035969
    Drives_construct (21)
    Construct_product (21)
    Microarray_results (42)
    Expression_cluster (137)
    Interaction (92)
    Anatomy_function: WBbtf0572
      WBbtf0573
      WBbtf0574
      WBbtf0575
  Map_info: Map: III Position: -3.78592 Error: 0.004728
    Well_ordered
    Positive: Positive_clone: C30D11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 862
        1079
        2799
        3603
        4091
        4458
  Reference (73)
  Remark: being swapped with mpk-1 at -4.05. was -3.93 [jah/sdm 5/99]
    klp-1 is the same gene as unc-103 and was therefore merged with this gene
  Method: Gene