WormBase Tree Display for Gene: WBGene00006831
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| WBGene00006831 | SMap | S_parent | Sequence | C52E12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-104 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C52E12.2 | ||||||||
| Molecular_name | C52E12.2a | ||||||||
| C52E12.2a.1 | |||||||||
| CE48050 | |||||||||
| C52E12.2b | |||||||||
| CE47855 | |||||||||
| C52E12.2a.2 | |||||||||
| C52E12.2b.1 | |||||||||
| Other_name | klp-1 | ||||||||
| CELE_C52E12.2 | Accession_evidence | NDB | BX284602 | ||||||
| Public_name | unc-104 | ||||||||
| DB_info | Database | AceView | gene | 2H299 | |||||
| WormQTL | gene | WBGene00006831 | |||||||
| WormFlux | gene | WBGene00006831 | |||||||
| NDB | locus_tag | CELE_C52E12.2 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00006831|UniProtKB=P23678 | |||||||
| family | PTHR24115 | ||||||||
| NCBI | gene | 174144 | |||||||
| RefSeq | protein | NM_001026870.7 | |||||||
| NM_171017.10 | |||||||||
| SwissProt | UniProtAcc | P23678 | |||||||
| UniProt_GCRP | UniProtAcc | P23678 | |||||||
| OMIM | gene | 601255 | |||||||
| 603060 | |||||||||
| 605995 | |||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00143874 | ||||||||
| Allele (221) | |||||||||
| Possibly_affected_by | WBVar02157549 | ||||||||
| WBVar02157550 | |||||||||
| WBVar02157551 | |||||||||
| WBVar02157552 | |||||||||
| WBVar02157553 | |||||||||
| Legacy_information | L e1265 : severe coiler; e1265/Df probably lethal. ES3 ME0. NA1. | ||||||||
| See also e2184 | |||||||||
| [C.elegansII] e1265 : severe coiler; Ric; defects in neuroanatomy; poor response to dauer pheromone;abnormal transport of synaptic vesicles. e1265/Df probably lethal. ES3 ME0. OA>5: rh43(viable, severe), rh142 (sublethal), ut60 (lethal, arrest as coiler), ut104, e2184::Tc1,rh1016, rh1017. Cloned: >30 kb gene, 6 kb transcript, encodes 1584 aa kinesin family protein. [Otsuka et al. 1991; Hall and Hedgecock 1991; Nguyen et al. 1995; DD; NJ] | |||||||||
| [Siddiqui SS]related to kinesin like protein by sequence similarity. | |||||||||
| Strain (19) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (81) | |||||||||
| Ortholog (51) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | unc-104 encodes a kinesin-like motor protein homologous to human axonal transporter of synaptic vesicles (ATSV, OMIM: 601255); UNC-104 is required for anterograde axonal transport of synaptic vesicles as well as differentiation of pre- and postsynaptic domains at inhibitory neuromuscular junctions; UNC-104 is expressed solely in neurons; UNC-104 retrograde movement is regulated by PTL-1/Tau, with which it physically interacts in vivo. | Paper_evidence | WBPaper00001424 | |||||
| WBPaper00005798 | |||||||||
| WBPaper00038442 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Aug 2011 00:00:00 | ||||||||
| Automated_description | Enables cytoskeletal protein binding activity; phosphatidylinositol phosphate binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including chemical synaptic transmission; regulation of cellular component organization; and regulation of cellular localization. Located in axon; presynapse; and somatodendritic compartment. Expressed in epithelial cell; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of the nervous system (multiple); carcinoma (multiple); and neuropathy (multiple). Is an ortholog of human KIF1A (kinesin family member 1A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (12) | ||||||||
| Molecular_info | Corresponding_CDS | C52E12.2a | |||||||
| C52E12.2b | |||||||||
| Corresponding_CDS_history | C52E12.2a:wp93 | ||||||||
| C52E12.2b:wp93 | |||||||||
| Corresponding_transcript | C52E12.2a.1 | ||||||||
| C52E12.2a.2 | |||||||||
| C52E12.2b.1 | |||||||||
| Other_sequence (59) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (12) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct (41) | |||||||||
| Construct_product (42) | |||||||||
| Antibody | WBAntibody00000733 | ||||||||
| WBAntibody00002213 | |||||||||
| Microarray_results (29) | |||||||||
| Expression_cluster (225) | |||||||||
| Interaction (134) | |||||||||
| Anatomy_function | WBbtf0455 | ||||||||
| WBbtf0456 | |||||||||
| WBbtf0457 | |||||||||
| Map_info | Map | II | Position | 0.210467 | Error | 0.00612 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mC6 | |||||||
| mDf18 | |||||||||
| Positive_clone | C47A5 | ||||||||
| C52E12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| DD#LAJ8 | |||||||||
| Negative | Outside_rearr | mcDf1 | |||||||
| Mapping_data | 2_point | 948 | |||||||
| 3709 | |||||||||
| 6169 | |||||||||
| Multi_point (16) | |||||||||
| Pos_neg_data | 544 | ||||||||
| 548 | |||||||||
| 554 | |||||||||
| 597 | |||||||||
| 619 | |||||||||
| 4514 | |||||||||
| 4221 | |||||||||
| 4222 | |||||||||
| 8958 | |||||||||
| 10270 | |||||||||
| Reference (308) | |||||||||
| Remark | yk16g10.3 removed from sequence list. sdm 11/00 | ||||||||
| klp-1 is the same gene as unc-104 and was therefore merged into unc-104 | |||||||||
| Method | Gene |
