WBGene00006831 | SMap | S_parent | Sequence | C52E12 |
| Identity | Version | 1 |
| | Name | CGC_name | unc-104 | Person_evidence | WBPerson261 |
| | | Sequence_name | C52E12.2 |
| | | Molecular_name | C52E12.2a |
| | | | C52E12.2a.1 |
| | | | CE48050 |
| | | | C52E12.2b |
| | | | CE47855 |
| | | | C52E12.2a.2 |
| | | | C52E12.2b.1 |
| | | Other_name | klp-1 |
| | | | CELE_C52E12.2 | Accession_evidence | NDB | BX284602 |
| | | Public_name | unc-104 |
| | DB_info | Database | AceView | gene | 2H299 |
| | | | WormQTL | gene | WBGene00006831 |
| | | | WormFlux | gene | WBGene00006831 |
| | | | NDB | locus_tag | CELE_C52E12.2 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006831|UniProtKB=P23678 |
| | | | | family | PTHR24115 |
| | | | NCBI | gene | 174144 |
| | | | RefSeq | protein | NM_001026870.7 |
| | | | | | NM_171017.10 |
| | | | SwissProt | UniProtAcc | P23678 |
| | | | UniProt_GCRP | UniProtAcc | P23678 |
| | | | OMIM | gene | 601255 |
| | | | | | 603060 |
| | | | | | 605995 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00143874 |
| | Allele (221) |
| | Possibly_affected_by | WBVar02157549 |
| | | WBVar02157550 |
| | | WBVar02157551 |
| | | WBVar02157552 |
| | | WBVar02157553 |
| | Legacy_information | L e1265 : severe coiler; e1265/Df probably lethal. ES3 ME0. NA1. |
| | | See also e2184 |
| | | [C.elegansII] e1265 : severe coiler; Ric; defects in neuroanatomy; poor response to dauer pheromone;abnormal transport of synaptic vesicles. e1265/Df probably lethal. ES3 ME0. OA>5: rh43(viable, severe), rh142 (sublethal), ut60 (lethal, arrest as coiler), ut104, e2184::Tc1,rh1016, rh1017. Cloned: >30 kb gene, 6 kb transcript, encodes 1584 aa kinesin family protein. [Otsuka et al. 1991; Hall and Hedgecock 1991; Nguyen et al. 1995; DD; NJ] |
| | | [Siddiqui SS]related to kinesin like protein by sequence similarity. |
| | Strain (19) |
| | RNASeq_FPKM (74) |
| | GO_annotation (81) |
| | Ortholog (51) |
| | Paralog (19) |
| | Structured_description | Concise_description | unc-104 encodes a kinesin-like motor protein homologous to human axonal transporter of synaptic vesicles (ATSV, OMIM: 601255); UNC-104 is required for anterograde axonal transport of synaptic vesicles as well as differentiation of pre- and postsynaptic domains at inhibitory neuromuscular junctions; UNC-104 is expressed solely in neurons; UNC-104 retrograde movement is regulated by PTL-1/Tau, with which it physically interacts in vivo. | Paper_evidence | WBPaper00001424 |
| | | | | | WBPaper00005798 |
| | | | | | WBPaper00038442 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 09 Aug 2011 00:00:00 |
| | | Automated_description | Enables cytoskeletal protein binding activity; phosphatidylinositol phosphate binding activity; and plus-end-directed microtubule motor activity. Involved in several processes, including chemical synaptic transmission; regulation of cellular component organization; and regulation of cellular localization. Located in axon; presynapse; and somatodendritic compartment. Expressed in epithelial cell; muscle cell; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of the nervous system (multiple); carcinoma (multiple); and neuropathy (multiple). Is an ortholog of human KIF1A (kinesin family member 1A). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (12) |
| Molecular_info | Corresponding_CDS | C52E12.2a |
| | | C52E12.2b |
| | Corresponding_CDS_history | C52E12.2a:wp93 |
| | | C52E12.2b:wp93 |
| | Corresponding_transcript | C52E12.2a.1 |
| | | C52E12.2a.2 |
| | | C52E12.2b.1 |
| | Other_sequence (59) |
| | Associated_feature (12) |
| Experimental_info | RNAi_result (12) |
| | Expr_pattern (15) |
| | Drives_construct (41) |
| | Construct_product (42) |
| | Antibody | WBAntibody00000733 |
| | | WBAntibody00002213 |
| | Microarray_results (29) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00027022:tax-6(jh107)_upregulated |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1225 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1494 |
| | | WBPaper00029359_1546 |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00033065:cyc-1(RNAi)_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_CoreEnriched |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_larva_enriched |
| | | WBPaper00037950:AVA-neuron_embryo_enriched |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_CoreEnriched |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050344:PLM-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | | WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051265:F4_hrde-1(tm1200)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated |
| | | WBPaper00053606:N2_vs_elt-2(ca15)_downregulated |
| | | WBPaper00055103:thoc-5(wy822)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055648:nerve-ring_expressed |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:DietaryRestriction_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058725:sftb-1(cer39)_downregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060951:mrpl-2(osa3)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061210:huIs179_upregulated |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:AUA |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVG |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:DD |
| | | WBPaper00061340:DVA |
| | | WBPaper00061340:I5 |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RID |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RIS |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:RME |
| | | WBPaper00061340:SIA |
| | | WBPaper00061405:S.aureus_downregulated_starvation |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:syd-1_2945-unc-41_2170 |
| | | WBPaper00061527:unc-13_19769-unc-13_278 |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:AVD_enriched |
| | | WBPaper00061651:AVG_enriched |
| | | WBPaper00061651:AVL_enriched |
| | | WBPaper00061651:AVM_enriched |
| | | WBPaper00061651:DB_enriched |
| | | WBPaper00061651:DVC_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:PLN_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00061651:PVT_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:RID_enriched |
| | | WBPaper00061651:RIG_enriched |
| | | WBPaper00061651:SDQ_enriched |
| | | WBPaper00061651:SIA_enriched |
| | | WBPaper00061651:SIB_enriched |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00061902:camt-1(ok515)_regulated_URX-AQR-PQR |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062056:lin-15B(n744)_upregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064789:Day12_vs_Day1_upregulated_neuron |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected |
| | | WBPaper00065258:anchor-cell_enriched |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:28_0 |
| | | WBPaper00065841:46_0 |
| | | WBPaper00065841:49_0 |
| | | WBPaper00065841:51_0 |
| | | WBPaper00065841:51_1 |
| | | WBPaper00065841:68_0 |
| | | WBPaper00065841:74_0 |
| | | WBPaper00065841:75_0 |
| | | WBPaper00065841:86_0 |
| | | WBPaper00065841:97_0 |
| | | WBPaper00065841:103_0 |
| | | WBPaper00065841:114_0 |
| | | WBPaper00065841:129_0 |
| | | WBPaper00065841:137_0 |
| | | WBPaper00065841:138_0 |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4489_group_19 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00036130:mir-243_up_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040858:eQTL_regulated_reproductive |
| | | WBPaper00040985:AIN-2_asynchronous_intestine |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_3h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (134) |
| | Anatomy_function | WBbtf0455 |
| | | WBbtf0456 |
| | | WBbtf0457 |
| Map_info | Map | II | Position | 0.210467 | Error | 0.00612 |
| | Well_ordered |
| | Positive | Inside_rearr | mC6 |
| | | | mDf18 |
| | | Positive_clone | C47A5 |
| | | | C52E12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | DD#LAJ8 |
| | Negative | Outside_rearr | mcDf1 |
| | Mapping_data | 2_point | 948 |
| | | | 3709 |
| | | | 6169 |
| | | Multi_point (16) |
| | | Pos_neg_data | 544 |
| | | | 548 |
| | | | 554 |
| | | | 597 |
| | | | 619 |
| | | | 4514 |
| | | | 4221 |
| | | | 4222 |
| | | | 8958 |
| | | | 10270 |
| Reference (308) |
| Remark | yk16g10.3 removed from sequence list. sdm 11/00 |
| | klp-1 is the same gene as unc-104 and was therefore merged into unc-104 |
| Method | Gene |