WBGene00006833 | SMap | S_parent | Sequence | F53F10 |
| Identity | Version | 2 |
| | Name | CGC_name | unc-108 | Person_evidence | WBPerson261 |
| | | Sequence_name | F53F10.4 |
| | | Molecular_name (12) |
| | | Other_name | rab-2 |
| | | | unc-67 | Person_evidence | WBPerson261 |
| | | | CELE_F53F10.4 | Accession_evidence | NDB | BX284601 |
| | | Public_name | unc-108 |
| | DB_info | Database | AceView | gene | 1E393 |
| | | | WormQTL | gene | WBGene00006833 |
| | | | WormFlux | gene | WBGene00006833 |
| | | | NDB | locus_tag | CELE_F53F10.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00006833|UniProtKB=A0A2C9C2Y0 |
| | | | | family | PTHR47979 |
| | | | NCBI | gene | 171956 |
| | | | RefSeq | protein | NM_001356805.3 |
| | | | | | NM_001393282.1 |
| | | | | | NM_001356804.3 |
| | | | | | NM_001356806.3 |
| | | | TrEMBL | UniProtAcc | A0A2C9C2Y0 |
| | | | | | A0A2C9C3C9 |
| | | | | | O01577 |
| | | | | | A0A2C9C379 |
| | | | UniProt_GCRP | UniProtAcc | A0A2C9C2Y0 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 18 Nov 2008 14:39:11 | WBPerson2970 | Event | Acquires_merge | WBGene00006800 |
| | | | | | | Name_change | Other_name | unc-67 |
| | | Acquires_merge | WBGene00006800 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00089559 |
| | Allele (58) |
| | Legacy_information | n501dm : sluggish poor backing. Similar phenotype in n501/+. ES3. NA1. Possibly haplo-insufficient locus. |
| | | See also n501, n777 |
| | | [C.elegansII] n501dm : sluggish, poor backing. Similar phenotype in n501/+. ES3. OA1: n777. Possibly haplo-insufficient locus. [Park and Horvitz 1986a] |
| | | e713 : sluggish can move well both forward and backward but frequently pauses or jams up. ES2 ME2. NA1. |
| | | [C.elegansII] e713 : sluggish, can move well both forward and backward but frequently pauses or jams up. ES2 ME2. NA1. [Brenner 1974; MQ] |
| | Strain | WBStrain00023643 |
| | | WBStrain00026794 |
| | | WBStrain00026882 |
| | | WBStrain00036101 |
| | | WBStrain00040847 |
| | | WBStrain00004200 |
| | RNASeq_FPKM (74) |
| | GO_annotation (38) |
| | Contained_in_operon | CEOP1116 |
| | Ortholog (37) |
| | Paralog (32) |
| | Structured_description | Concise_description | unc-108 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; unc-108 function is required in neurons for normal locomotion; unc-108 also functions in the removal of apoptotic cells, specifically it functions in engulfing cells for the recruitment and fusion of the lysosome to the phagosome; unc-108 is expressed in neurons and in engulfing cells. | Paper_evidence | WBPaper00015788 |
| | | | | | WBPaper00031470 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson324 |
| | | | | Date_last_updated | 14 Aug 2008 00:00:00 |
| | | Automated_description | Enables GTPase activity. Involved in several processes, including dense core granule maturation; phagosome maturation involved in apoptotic cell clearance; and regulation of locomotion involved in locomotory behavior. Located in axon; cytoplasm; and neuronal cell body. Expressed in several structures, including excretory gland cell; hermaphrodite somatic gonadal cell; neurons; pharyngeal gland cell; and rectal gland cell. Is an ortholog of human RAB2A (RAB2A, member RAS oncogene family). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | F53F10.4a |
| | | F53F10.4b |
| | | F53F10.4c |
| | | F53F10.4d |
| | Corresponding_transcript | F53F10.4a.1 |
| | | F53F10.4b.1 |
| | | F53F10.4c.1 |
| | | F53F10.4d.1 |
| | Other_sequence (24) |
| | Associated_feature (11) |
| Experimental_info | RNAi_result (40) |
| | Expr_pattern (16) |
| | Drives_construct | WBCnstr00002664 |
| | | WBCnstr00005792 |
| | | WBCnstr00005793 |
| | | WBCnstr00013020 |
| | | WBCnstr00013022 |
| | | WBCnstr00013277 |
| | | WBCnstr00013541 |
| | | WBCnstr00019190 |
| | | WBCnstr00034128 |
| | Construct_product (21) |
| | Antibody | WBAntibody00001993 |
| | | WBAntibody00001994 |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00032528:L3_enriched |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_L2-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00040221:DAF-12_target_ALF4 |
| | | WBPaper00040965:lipid-droplet_associated_protein |
| | | WBPaper00044426:rotenone_24h_upregulated |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045314:S.aureus-induced_N2 |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045974:NSM_enriched_DSN-treated_RNAseq |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00046161:Q40-aggregate-protein_Day7_Sarcosyl-soluble |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_downregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050448:KGB-1-induced |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050990:arcade_intestinal-valve_expressed |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:pharynx_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_nucleus_expressed |
| | | WBPaper00051245:intestine_cytoplasm_expressed |
| | | WBPaper00051245:intestine_nucleus_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051558:fog-2(q71)_regulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_downregulated |
| | | WBPaper00053295:lin-22(ot269)_downregulated |
| | | WBPaper00053388:dauer_regulated_Cluster4 |
| | | WBPaper00053814:25C_downregulated_PY79 |
| | | WBPaper00055049:S.gordonii_upregulated |
| | | WBPaper00055482:pmt-2(RNAi)_upregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059174:MEG-3_interacting |
| | | WBPaper00059356:BAZ-2_SET-6_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AIY |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:PVT |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:cdc-42_17192-rab-5_18073 |
| | | WBPaper00061527:nhr-46_2300-unc-108_2961 |
| | | WBPaper00061651:ADA_enriched |
| | | WBPaper00061651:ADE_enriched |
| | | WBPaper00061651:AIZ_enriched |
| | | WBPaper00061651:AVF_enriched |
| | | WBPaper00061651:HSN_enriched |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061651:PDE_enriched |
| | | WBPaper00061651:PVM_enriched |
| | | WBPaper00061651:PVR_enriched |
| | | WBPaper00061651:PVW_enriched |
| | | WBPaper00061651:RIG_enriched |
| | | WBPaper00061651:RIH_enriched |
| | | WBPaper00061651:RIP_enriched |
| | | WBPaper00061651:RIV_enriched |
| | | WBPaper00061651:VB01_enriched |
| | | WBPaper00061651:VB02_enriched |
| | | WBPaper00061651:VB_enriched |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064871:hypoxia_downregulated_F1 |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065158:AFD_depleted |
| | | WBPaper00065373:sek-1(km4)_downregulated_Ref |
| | | cgc4386_cluster_4_4 |
| | | cgc4489_group_16 |
| | | WBPaper00025032:cluster_43 |
| | | WBPaper00025032:cluster_62 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032948:StarveUp2 |
| | | WBPaper00034739:N2moreDR1350 |
| | | WBPaper00034757:up_by_oxidative_stress |
| | | WBPaper00035084:L1_enriched_AIN-2_IP |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036123:Fluoranthene_regulated |
| | | WBPaper00037901:GLD-1_mRNA_targets |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5 |
| | | WBPaper00041606:CE_B.thuringiensis-DB27_regulated |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00048989:N2_allantoin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(143_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (51) |
| | WBProcess | WBbiopr:00000013 |
| | | WBbiopr:00000015 |
| Map_info | Map | I | Position | -2.00793 | Error | 0.05662 |
| | Positive | Positive_clone | F53F10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | | | From CDS info |
| | Mapping_data | 2_point | 59 |
| | | | 80 |
| | | | 489 |
| | | | 490 |
| | | Multi_point | 1290 |
| | | | 1291 |
| | | | 4973 |
| | | | 5623 |
| | | | 380 |
| | | | 381 |
| | | | 1288 |
| | | Pos_neg_data | 363 |
| Reference (55) |
| Method | Gene |