WormBase Tree Display for Gene: WBGene00006843
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| WBGene00006843 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | unc-119 | Person_evidence | WBPerson261 | |||||
| Sequence_name | M142.1 | ||||||||
| Molecular_name | M142.1a | ||||||||
| M142.1a.1 | |||||||||
| CE06203 | |||||||||
| M142.1b | |||||||||
| CE43523 | |||||||||
| M142.1c | |||||||||
| CE44343 | |||||||||
| M142.1b.1 | |||||||||
| M142.1c.1 | |||||||||
| Other_name | 3L997 | Inferred_automatically | |||||||
| CELE_M142.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | unc-119 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Allele (132) | |||||||||
| Possibly_affected_by | WBVar02152819 | ||||||||
| WBVar02153069 | |||||||||
| WBVar02153167 | |||||||||
| WBVar02153169 | |||||||||
| WBVar02153170 | |||||||||
| WBVar02153171 | |||||||||
| WBVar02153173 | |||||||||
| WBVar02154063 | |||||||||
| WBVar02158600 | |||||||||
| WBVar02158612 | |||||||||
| Legacy_information | See also e2498 | ||||||||
| [Maduro & Pilgrim] e2498::Tc1: strong unc, almost paralyzed adults, dumpyish, tends to curl; daf-d (daf-7 suppressible), weak FITC uptake; partially Egl; similar phenotype to eDf2; eDp6. ES3 (all stages), ME0. NA4 (ed3op, ed4oc, ed9: all similar to e2498, all putative nulls). Ref. DP. | |||||||||
| [C.elegansII] e2498::Tc1 : severe Unc, almost paralysed adults,dumpyish, tends to curl; Daf-d, partial Egl, partial Dyf. Normal muscle ultrastructure.ES3. ME0. OA3: ed3op, ed4oc, ed9 (all similar). Cloned: encodes predicted 219 aa novel protein. unc-119:GFP expressed extensively in axons. [Maduro & Pilgrim 1995] | |||||||||
| Strain (2313) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (38) | |||||||||
| Paralog | WBGene00003966 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Structured_description | Concise_description | unc-119 encodes a novel protein that is highly conserved amongst metazoans; unc-119 activity is required for proper development of the nervous system, including axonal branching and fasciculation, and hence, for normal movement, chemosensation, and feeding; unc-119 is expressed pan-neuronally beginning in the early embryo (~60 cells) and continuing through adulthood; although the molecular function of UNC-119 is not yet known, human UNC119, which can rescue C. elegans unc-119 mutant animals, is reported to function as a receptor-associated activator of signal transduction; thus, UNC-119 may be part of a signal transduction pathway that mediates axonal patterning in response to external developmental cues. | Paper_evidence | WBPaper00002306 | |||||
| WBPaper00003926 | |||||||||
| WBPaper00024591 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 15 Dec 2004 00:00:00 | ||||||||
| Automated_description | Predicted to enable lipid binding activity. Involved in several processes, including body morphogenesis; dauer larval development; and regulation of multicellular organismal process. Located in axon. Expressed in several structures, including body wall musculature; ganglia; neurons; seam cell; and somatic nervous system. Human ortholog(s) of this gene implicated in cone-rod dystrophy and immunodeficiency 13. Is an ortholog of human UNC119 (unc-119 lipid binding chaperone) and UNC119B (unc-119 lipid binding chaperone B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111987 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12565) | ||||
| DOID:0050572 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:12565) | ||||||
| Molecular_info | Corresponding_CDS | M142.1a | |||||||
| M142.1b | |||||||||
| M142.1c | |||||||||
| Corresponding_transcript | M142.1a.1 | ||||||||
| M142.1b.1 | |||||||||
| M142.1c.1 | |||||||||
| Other_sequence (63) | |||||||||
| Associated_feature (12) | |||||||||
| Experimental_info | RNAi_result (13) | ||||||||
| Expr_pattern (18) | |||||||||
| Drives_construct (109) | |||||||||
| Construct_product | WBCnstr00000424 | ||||||||
| WBCnstr00001713 | |||||||||
| WBCnstr00001715 | |||||||||
| WBCnstr00001716 | |||||||||
| WBCnstr00001717 | |||||||||
| WBCnstr00001718 | |||||||||
| WBCnstr00001719 | |||||||||
| WBCnstr00001720 | |||||||||
| WBCnstr00001721 | |||||||||
| WBCnstr00001722 | |||||||||
| WBCnstr00001723 | |||||||||
| WBCnstr00001724 | |||||||||
| WBCnstr00001725 | |||||||||
| WBCnstr00001726 | |||||||||
| WBCnstr00001961 | |||||||||
| WBCnstr00001971 | |||||||||
| WBCnstr00005603 | |||||||||
| WBCnstr00005860 | |||||||||
| WBCnstr00011625 | |||||||||
| WBCnstr00012509 | |||||||||
| WBCnstr00014606 | |||||||||
| WBCnstr00015134 | |||||||||
| WBCnstr00015135 | |||||||||
| WBCnstr00015136 | |||||||||
| WBCnstr00016182 | |||||||||
| WBCnstr00016674 | |||||||||
| WBCnstr00017080 | |||||||||
| WBCnstr00018308 | |||||||||
| WBCnstr00019509 | |||||||||
| WBCnstr00019531 | |||||||||
| WBCnstr00019580 | |||||||||
| WBCnstr00020004 | |||||||||
| WBCnstr00020353 | |||||||||
| WBCnstr00020367 | |||||||||
| WBCnstr00021633 | |||||||||
| WBCnstr00022486 | |||||||||
| WBCnstr00022843 | |||||||||
| WBCnstr00038158 | |||||||||
| WBCnstr00038754 | |||||||||
| WBCnstr00038770 | |||||||||
| WBCnstr00041065 | |||||||||
| Antibody | WBAntibody00000421 | ||||||||
| WBAntibody00002511 | |||||||||
| WBAntibody00002695 | |||||||||
| Microarray_results (21) | |||||||||
| Expression_cluster (150) | |||||||||
| Interaction (303) | |||||||||
| Map_info | Map | III | Position | 5.58925 | Error | 0.00446 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C27F7 | |||||||
| C44B9 | |||||||||
| M142 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Y39A1 | |||||||||
| Y60D9 | |||||||||
| Negative | Negative_clone | K02B6 | |||||||
| K11D9 | |||||||||
| T27G1 | |||||||||
| Mapping_data | 2_point | 4972 | |||||||
| 4973 | |||||||||
| 4974 | |||||||||
| Multi_point (3) | |||||||||
| Pos_neg_data | 4970 | ||||||||
| 4971 | |||||||||
| Reference (258) | |||||||||
| Remark | a sequence search shows strong similarity to C27H5.1 (II): a 92 a.a. region shows 26% identity, 51% similarity to UNC-119. | ||||||||
| Method | Gene |
