WormBase Tree Display for Gene: WBGene00006853

WBGene00006853 SMap: S_parent: Sequence: C47G2
  Identity: Version: 1
    Name: CGC_name: unc-130 Person_evidence: WBPerson261
      Sequence_name: C47G2.2
      Molecular_name: C47G2.2
        C47G2.2.1
        CE02166
      Other_name: CELE_C47G2.2 Accession_evidence: NDB BX284602
      Public_name: unc-130
    DB_info: Database: AceView gene 2L573
        WormQTL gene WBGene00006853
        WormFlux gene WBGene00006853
        NDB locus_tag CELE_C47G2.2
        Panther gene CAEEL|WormBase=WBGene00006853|UniProtKB=Q18694
          family PTHR11829
        NCBI gene 174721
        RefSeq protein NM_064010.5
        SwissProt UniProtAcc Q18694
        UniProt_GCRP UniProtAcc Q18694
        OMIM gene 611539
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:43 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Allele (36)
    Strain: WBStrain00031123
      WBStrain00040542
      WBStrain00029988
    RNASeq_FPKM (74)
    GO_annotation (27)
    Ortholog (60)
    Paralog: WBGene00001434 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001438 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001440 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00001441 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00001442 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002601 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003017 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003976 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004013 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00000912 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Concise_description: A member of the forkhead domain family of transcription factors that affects the generation of the AWA and ASG chemosensory neurons and is partially required for male tail morphogenesis and embryogenesis; it is expressed in the AWA and ASG precursors; it is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor. Paper_evidence: WBPaper00004379
            WBPaper00004380
          Curator_confirmed: WBPerson324
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription corepressor activity. Involved in several processes, including axon extension involved in axon guidance; negative regulation of transcription by RNA polymerase II; and nematode male tail tip morphogenesis. Located in nucleus. Expressed in several structures, including HO neuron; hypodermis; ray; tail; and ventral body wall muscle. Human ortholog(s) of this gene implicated in glaucoma and vitiligo. Is an ortholog of several human genes including FOXD3 (forkhead box D3); FOXD4 (forkhead box D4); and FOXD4L1 (forkhead box D4 like 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:1686 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3804)
      DOID:12306 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:3804)
  Molecular_info: Corresponding_CDS: C47G2.2
    Corresponding_transcript: C47G2.2.1
    Other_sequence: Dviv_isotig17565
      CR11553
      Dviv_isotig17564
      CBC08749_1
      CRC07576_1
      CR11552
      JI182349.1
      JI165252.1
    Associated_feature (15)
    Gene_product_binds (1114)
    Transcription_factor: WBTranscriptionFactor000007
  Experimental_info: RNAi_result: WBRNAi00000983 Inferred_automatically: RNAi_primary
      WBRNAi00042701 Inferred_automatically: RNAi_primary
      WBRNAi00090262 Inferred_automatically: RNAi_primary
      WBRNAi00089792 Inferred_automatically: RNAi_primary
      WBRNAi00029926 Inferred_automatically: RNAi_primary
      WBRNAi00012086 Inferred_automatically: RNAi_primary
      WBRNAi00090104 Inferred_automatically: RNAi_primary
      WBRNAi00068017 Inferred_automatically: RNAi_primary
      WBRNAi00113567 Inferred_automatically: RNAi_primary
      WBRNAi00089944 Inferred_automatically: RNAi_primary
    Expr_pattern (16)
    Drives_construct: WBCnstr00000479
      WBCnstr00007747
      WBCnstr00014250
      WBCnstr00016521
      WBCnstr00034122
    Construct_product: WBCnstr00007747
      WBCnstr00014834
      WBCnstr00014906
      WBCnstr00015401
      WBCnstr00034122
    Antibody: WBAntibody00000322
    Microarray_results (20)
    Expression_cluster (127)
    Interaction (185)
    Product_binds_matrix: WBPmat00005569
  Map_info: Map: II Position: 3.40404 Error: 0.003003
    Well_ordered
    Positive: Positive_clone: C47G2 Person_evidence: WBPerson2286
          Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 3609
  Reference (49)
  Method: Gene