WormBase Tree Display for Gene: WBGene00006868
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| WBGene00006868 | SMap | S_parent | Sequence | M03A1 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | vab-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | M03A1.1 | ||||||||
| Molecular_name | M03A1.1 | ||||||||
| M03A1.1.1 | |||||||||
| CE25060 | |||||||||
| Other_name | CELE_M03A1.1 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | vab-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vab | ||||||||
| Reference_allele | WBVar00142901 | ||||||||
| Allele (418) | |||||||||
| Legacy_information | e2 : notched head variable dystrophy of ventral cephalic region especially in L1; penetrance < 70%. ES3/0 ME3. NA8 (e1063 : penetrance 35%; e2027spo : penetrance > 90%). | ||||||||
| See also e2, e116, e118, e200, e699, e721, e1063, e2027 | |||||||||
| [C.elegansII] e2 : notched head, variable dystrophy of ventral cephalic region, especially in L1; penetrance < 70%. ES3/0 ME3. OA>10: e1063 (penetrance 35%), e2027spo (penetrance > 90%), e699 etc. [Brenner 1974; Lewis and Hodgkin 1979; CB; CZ] | |||||||||
| Strain (24) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (38) | |||||||||
| Ortholog (113) | |||||||||
| Paralog (69) | |||||||||
| Structured_description | Concise_description | vab-1 encodes an ephrin receptor; during development, vab-1 activity is required for neural and epithelial morphogenesis as well as for proper axon targeting and neuronal cell migration; in addition, VAB-1 functions as a major sperm protein receptor in a sperm-sensing control mechanism that regulates oocyte meiotic maturation; VAB-1::GFP reporters are expressed in neuronal cells and in oocytes and sheath cells of the proximal gonad. | Paper_evidence | WBPaper00003020 | |||||
| WBPaper00003843 | |||||||||
| WBPaper00005670 | |||||||||
| WBPaper00027013 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Feb 2007 00:00:00 | ||||||||
| Automated_description | Enables ephrin receptor activity and protein domain specific binding activity. Involved in several processes, including cell development; embryonic morphogenesis; and regulation of axon guidance. Located in axon and plasma membrane. Expressed in several structures, including hypodermal cell; neuroblasts; neurons; oocyte; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; aortic dissection; cataract 6 multiple types; and gastrointestinal system cancer (multiple). Is an ortholog of several human genes including EPHB1 (EPH receptor B1); EPHB2 (EPH receptor B2); and EPHB3 (EPH receptor B3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model (14) | ||||||||
| Molecular_info | Corresponding_CDS | M03A1.1 | |||||||
| Corresponding_CDS_history | M03A1.1b:wp274 | ||||||||
| Corresponding_transcript | M03A1.1.1 | ||||||||
| Other_sequence (11) | |||||||||
| Associated_feature (54) | |||||||||
| Experimental_info | RNAi_result (27) | ||||||||
| Expr_pattern (16) | |||||||||
| Drives_construct | WBCnstr00000707 | ||||||||
| WBCnstr00006419 | |||||||||
| WBCnstr00009616 | |||||||||
| WBCnstr00018076 | |||||||||
| WBCnstr00034120 | |||||||||
| WBCnstr00042438 | |||||||||
| Construct_product (15) | |||||||||
| Antibody | WBAntibody00000876 | ||||||||
| WBAntibody00001049 | |||||||||
| WBAntibody00001576 | |||||||||
| WBAntibody00002037 | |||||||||
| WBAntibody00002313 | |||||||||
| Microarray_results (28) | |||||||||
| Expression_cluster (158) | |||||||||
| Interaction (248) | |||||||||
| Anatomy_function | WBbtf0217 | ||||||||
| WBbtf0220 | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000068 | |||||||||
| WBbiopr:00000120 | |||||||||
| Map_info | Map | II | Position | -3.85469 | Error | 0.013028 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | mDf14 | |||||||
| mDf15 | |||||||||
| Positive_clone | M03A1 | Person_evidence | WBPerson105 | ||||||
| Inferred_automatically | From sequence, transcript, pseudogene data | ||||||||
| Mapping_data | 2_point | 266 | |||||||
| Multi_point | 48 | ||||||||
| 881 | |||||||||
| 882 | |||||||||
| 1880 | |||||||||
| 4031 | |||||||||
| 4032 | |||||||||
| Pos_neg_data (12) | |||||||||
| Reference (154) | |||||||||
| Method | Gene |
