WBGene00006868 | SMap | S_parent | Sequence | M03A1 |
| Identity | Version | 1 |
| | Name | CGC_name | vab-1 | Person_evidence | WBPerson261 |
| | | Sequence_name | M03A1.1 |
| | | Molecular_name | M03A1.1 |
| | | | M03A1.1.1 |
| | | | CE25060 |
| | | Other_name | CELE_M03A1.1 | Accession_evidence | NDB | BX284602 |
| | | Public_name | vab-1 |
| | DB_info | Database (13) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | vab |
| | Reference_allele | WBVar00142901 |
| | Allele (418) |
| | Legacy_information | e2 : notched head variable dystrophy of ventral cephalic region especially in L1; penetrance < 70%. ES3/0 ME3. NA8 (e1063 : penetrance 35%; e2027spo : penetrance > 90%). |
| | | See also e2, e116, e118, e200, e699, e721, e1063, e2027 |
| | | [C.elegansII] e2 : notched head, variable dystrophy of ventral cephalic region, especially in L1; penetrance < 70%. ES3/0 ME3. OA>10: e1063 (penetrance 35%), e2027spo (penetrance > 90%), e699 etc. [Brenner 1974; Lewis and Hodgkin 1979; CB; CZ] |
| | Strain (24) |
| | RNASeq_FPKM (74) |
| | GO_annotation (38) |
| | Ortholog (113) |
| | Paralog (69) |
| | Structured_description | Concise_description | vab-1 encodes an ephrin receptor; during development, vab-1 activity is required for neural and epithelial morphogenesis as well as for proper axon targeting and neuronal cell migration; in addition, VAB-1 functions as a major sperm protein receptor in a sperm-sensing control mechanism that regulates oocyte meiotic maturation; VAB-1::GFP reporters are expressed in neuronal cells and in oocytes and sheath cells of the proximal gonad. | Paper_evidence | WBPaper00003020 |
| | | | | | WBPaper00003843 |
| | | | | | WBPaper00005670 |
| | | | | | WBPaper00027013 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 28 Feb 2007 00:00:00 |
| | | Automated_description | Enables ephrin receptor activity and protein domain specific binding activity. Involved in several processes, including cell development; embryonic morphogenesis; and regulation of axon guidance. Located in axon and plasma membrane. Expressed in several structures, including hypodermal cell; neuroblasts; neurons; oocyte; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; aortic dissection; cataract 6 multiple types; and gastrointestinal system cancer (multiple). Is an ortholog of several human genes including EPHB1 (EPH receptor B1); EPHB2 (EPH receptor B2); and EPHB3 (EPH receptor B3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model (14) |
| Molecular_info | Corresponding_CDS | M03A1.1 |
| | Corresponding_CDS_history | M03A1.1b:wp274 |
| | Corresponding_transcript | M03A1.1.1 |
| | Other_sequence (11) |
| | Associated_feature (54) |
| Experimental_info | RNAi_result (27) |
| | Expr_pattern (16) |
| | Drives_construct | WBCnstr00000707 |
| | | WBCnstr00006419 |
| | | WBCnstr00009616 |
| | | WBCnstr00018076 |
| | | WBCnstr00034120 |
| | | WBCnstr00042438 |
| | Construct_product (15) |
| | Antibody | WBAntibody00000876 |
| | | WBAntibody00001049 |
| | | WBAntibody00001576 |
| | | WBAntibody00002037 |
| | | WBAntibody00002313 |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00030922:glycosylated_protein |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00035269:cde-1_regulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044656:tatn-1(qd182)_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044760:germline_specific |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_downregulated |
| | | WBPaper00045420:fertilization_downregulated_transcript |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045729:gld-2(RNAi)_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050015:ifg-1(RNAi)_upregulated |
| | | WBPaper00050234:lin-28(RNAi)_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C |
| | | WBPaper00050496:unc-39(hp701)_regulated |
| | | WBPaper00050712:RC301_vs_DA650_4h-PA_upregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051039:germline_enriched |
| | | WBPaper00052884:emb-4(hc60)_downregulated |
| | | WBPaper00053184:sma-2(rax5)_downregulated |
| | | WBPaper00053184:sma-4(rax3)_downregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00053810:nuo-6(qm200)_downregulated |
| | | WBPaper00053814:15C_downregulated_OP50 |
| | | WBPaper00055226:ADR-2_target_N2 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Metformin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rapamycin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055626:pry-1(mu38)_upregulated |
| | | WBPaper00055648:germline_expressed |
| | | WBPaper00055971:nhl-2(ok818)_25C_upregulated |
| | | WBPaper00056284:ints-5(RNAi)_downregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057154:HeatShock_upregulated_miRNA-target |
| | | WBPaper00057288:iff-1(RNAi)_upregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060683:hlh-11(ko1)_downregulated |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_upregulated |
| | | WBPaper00061007:HB101_downregulated |
| | | WBPaper00061007:S.aquatilis_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ABarpaaa_lineage |
| | | WBPaper00061340:ALM_BDU |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:CAN |
| | | WBPaper00061340:CEPsh |
| | | WBPaper00061340:DVC |
| | | WBPaper00061340:FLP |
| | | WBPaper00061340:F_U |
| | | WBPaper00061340:g2_parent |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:Intestinal_and_rectal_muscle |
| | | WBPaper00061340:K_Kprime |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061340:Neuroblast_HSN_PHB |
| | | WBPaper00061340:Neuroblast_PVC_LUA |
| | | WBPaper00061340:Neuroblast_URX_CEPDx |
| | | WBPaper00061340:Parents_of_U_F_B_DVA |
| | | WBPaper00061340:Parent_of_PVP_and_rect_V |
| | | WBPaper00061340:PLM_ALN_grandparent |
| | | WBPaper00061340:PLM_ALN_great_grandparent |
| | | WBPaper00061340:rect_D |
| | | WBPaper00061527:mbk-2_1585-tol-1_22538 |
| | | WBPaper00061527:npp-8_4368-E01B7.1_7741 |
| | | WBPaper00061651:MC_enriched |
| | | WBPaper00061651:PDA_enriched |
| | | WBPaper00061651:VA12_enriched |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated |
| | | WBPaper00064502:spe-44(fx110)_upregulated |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:Day10_vs_Day1_upregulated |
| | | WBPaper00065835:Day11_vs_Day1_upregulated |
| | | WBPaper00065841:44_0 |
| | | WBPaper00065841:65_0 |
| | | WBPaper00065841:108_0 |
| | | WBPaper00065841:118_0 |
| | | WBPaper00065841:119_0 |
| | | WBPaper00065841:136_0 |
| | | WBPaper00065993:glp-1(e2141)_downregulated |
| | | WBPaper00066110:Doxorubicin_downregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_downregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14 |
| | | cgc4386_cluster_6_4 |
| | | cgc4489_group_2 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00027111:rrf-2(ok210)_upregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035084:embryo_enriched_AIN-2_IP |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00040210:Chlorpyrifos_24C_regulated |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00040963:TA300_down |
| | | WBPaper00041002:HQ_3d_2.0mM_Down |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(23_min) |
| | | [cgc5767]:expression_class_SE |
| | | [cgc5767]:expression_class_SE_pi(23_min) |
| | | [cgc6390]:Cluster_E |
| | | [cgc6390]:oogenesis-enriched |
| | Interaction (248) |
| | Anatomy_function | WBbtf0217 |
| | | WBbtf0220 |
| | WBProcess | WBbiopr:00000001 |
| | | WBbiopr:00000068 |
| | | WBbiopr:00000120 |
| Map_info | Map | II | Position | -3.85469 | Error | 0.013028 |
| | Well_ordered |
| | Positive | Inside_rearr | mDf14 |
| | | | mDf15 |
| | | Positive_clone | M03A1 | Person_evidence | WBPerson105 |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 266 |
| | | Multi_point | 48 |
| | | | 881 |
| | | | 882 |
| | | | 1880 |
| | | | 4031 |
| | | | 4032 |
| | | Pos_neg_data (12) |
| Reference (154) |
| Method | Gene |