WormBase Tree Display for Gene: WBGene00006874
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| WBGene00006874 | SMap | S_parent | Sequence | CHROMOSOME_V | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | vab-8 | Person_evidence | WBPerson261 | |||||
| Sequence_name | K12F2.2 | ||||||||
| Molecular_name | K12F2.2a | ||||||||
| K12F2.2a.1 | |||||||||
| CE31041 | |||||||||
| K12F2.2b | |||||||||
| CE23870 | |||||||||
| K12F2.2c | |||||||||
| CE21070 | |||||||||
| K12F2.2b.1 | |||||||||
| K12F2.2c.1 | |||||||||
| Other_name | unc-107 | ||||||||
| klp-5 | |||||||||
| CELE_K12F2.2 | Accession_evidence | NDB | BX284605 | ||||||
| Public_name | vab-8 | ||||||||
| DB_info | Database (12) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | vab | ||||||||
| Reference_allele | WBVar00143682 | ||||||||
| Allele (176) | |||||||||
| Legacy_information | e1017 : posterior half thin pale uncoordinated anterior half normal; adult male tail anatomy vestigial; failure of posterior migration of CAN cells; rare animals have normal posterior morphology and one correctly placed CAN cell. ES3 ME0. Similar phenotypes in e1017/Df. NA2 (ct33 (resembles e1017 sometimes abnormal HSN migration)). | ||||||||
| See also e1017 | |||||||||
| ev411 : slightly uncoordinated partially shortened phasmid axons. Phenotype enhanced by one or two doses of enu-1(ev419) ev411; ev419 is severely uncoordinated very short phasmid axons cannot back. | |||||||||
| [C.elegansII] e1017 : posterior half thin, pale, uncoordinated; anterior half normal; adult male tail anatomy vestigial; failure of posterior migration of CAN cells; rare animals have normal posterior morphology and one correctly placed CAN cell.Similar phenotypes in e1017/Df. ES3 ME0. OA>5: ct33 (resembles e1017, sometimes abnormal HSN migration),ev411 (pka unc-107, slightly uncoordinated, partially shortened phasmidaxons. Unc phenotype enhanced byone or two doses of enu-1(ev419), ev411; ev419 is severely uncoordinated, cannot back, very short phasmid axons). Multiple phenotypic classes; some mutations affect only certain migrations. Cloned: multiple transcripts[Hedgecock et al. 1985; JW, LK; NG; NJ; NW] | |||||||||
| Strain | WBStrain00027090 | ||||||||
| WBStrain00028749 | |||||||||
| WBStrain00029115 | |||||||||
| WBStrain00029117 | |||||||||
| WBStrain00034370 | |||||||||
| WBStrain00003976 | |||||||||
| WBStrain00003984 | |||||||||
| WBStrain00004229 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (25) | |||||||||
| Ortholog (79) | |||||||||
| Paralog (19) | |||||||||
| Structured_description | Concise_description | The vab-8 gene encodes a novel protein containing an atypical kinesin-like motor domain that is required for many posteriorly-directed cell migrations, as well as axonal outgrowth and pathfinding; vab-8 encodes two protein isoforms: VAB-8S, a novel protein expressed in migrating cells, and VAB-8L, which contains a kinesin-related domain, is expressed in neurons and functions in growth cone migrations; VAB-8 interacts with UNC-51, a serine-threonine kinase also required for axon outgrowth. | Paper_evidence | WBPaper00003058 | |||||
| WBPaper00003627 | |||||||||
| WBPaper00024595 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 14 Nov 2005 00:00:00 | ||||||||
| Automated_description | Predicted to enable ATP binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including egg-laying behavior; generation of neurons; and negative regulation of motor neuron migration. Located in striated muscle thin filament. Expressed in body wall musculature and neurons. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Is an ortholog of human KIF26A (kinesin family member 26A) and KIF26B (kinesin family member 26B). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0090131 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20226) | ||||
| Molecular_info | Corresponding_CDS | K12F2.2a | |||||||
| K12F2.2b | |||||||||
| K12F2.2c | |||||||||
| Corresponding_CDS_history | K12F2.2a:wp80 | ||||||||
| Corresponding_transcript | K12F2.2a.1 | ||||||||
| K12F2.2b.1 | |||||||||
| K12F2.2c.1 | |||||||||
| Other_sequence (17) | |||||||||
| Associated_feature (24) | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr1433 | ||||||||
| Expr1012373 | |||||||||
| Expr1032914 | |||||||||
| Expr1154381 | |||||||||
| Expr2017953 | |||||||||
| Expr2036089 | |||||||||
| Drives_construct | WBCnstr00000560 | ||||||||
| WBCnstr00010275 | |||||||||
| WBCnstr00034117 | |||||||||
| Construct_product | WBCnstr00000563 | ||||||||
| WBCnstr00000569 | |||||||||
| WBCnstr00006352 | |||||||||
| WBCnstr00009442 | |||||||||
| WBCnstr00010275 | |||||||||
| WBCnstr00018321 | |||||||||
| WBCnstr00034117 | |||||||||
| Antibody | WBAntibody00000173 | ||||||||
| WBAntibody00000174 | |||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (178) | |||||||||
| Interaction (31) | |||||||||
| Anatomy_function | WBbtf0833 | ||||||||
| Map_info | Map | V | Position | 3.77514 | Error | 0.020663 | |||
| Well_ordered | |||||||||
| Positive | Positive_clone | C35G11 | |||||||
| K12F2 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| ZK836 | |||||||||
| Mapping_data | 2_point | 235 | |||||||
| 1726 | |||||||||
| Multi_point (17) | |||||||||
| Pos_neg_data | 1727 | ||||||||
| 1728 | |||||||||
| 1729 | |||||||||
| 6868 | |||||||||
| 1730 | |||||||||
| 7399 | |||||||||
| Reference (104) | |||||||||
| Remark | Previous sequence connection was to ZK836.3 which was merged into K12F2.2, 02/06/12 krb. | ||||||||
| Method | Gene |
